Effects “in Vitro” of Some Cardiovascular Drugs and Other Agents on Human Platelet Aggregation

G Sacchetti; D Bellani; C Montanari; A Gibelli

doi:10.1055/s-0038-1647759

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1973; 29(01): 190-195
DOI: 10.1055/s-0038-1647759

Original Article

Schattauer GmbH

Effects “in Vitro” of Some Cardiovascular Drugs and Other Agents on Human Platelet Aggregation

G Sacchetti

¹Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)

,

D Bellani

¹Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)

,

C Montanari

¹Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)

,

A Gibelli

¹Medical Department, Clinical Research Division, Carlo Erba, Milano and Centro Trasfusionale e Immuno-Ematologico, Ospedale S. Carlo Borromeo, Milano ( Italy)

› Institutsangaben

Abstract

Summary

The in vitro effect of the following substances on human platelet aggregation is studied: K 4423 (a ß-blocking drug), isoproterenol, phentolamine, papaverine, methamidoline (a myolytic agent).

None of these substances causes aggregation. All inhibit aggregation induced by ADP or noradrenaline, except for phentolamine, which is active only on noradrenaline- induced aggregation.

Hypothesis on the mechanism of action of the compounds tested are proposed.

Volltext

Referenzen

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