The Effect of Exocrine Pancreas Stimulation on the Coagulation and Fibrinolytic System in Dogs

A Gabryelewicz; J Prokopowicz; W Szalaj; N Wolosowicz; W Laszewicz; M Szmitkowski

doi:10.1055/s-0038-1647802

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1973; 29(03): 603-609
DOI: 10.1055/s-0038-1647802

Original Article

Schattauer GmbH

The Effect of Exocrine Pancreas Stimulation on the Coagulation and Fibrinolytic System in Dogs^[*]

A Gabryelewicz

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

,

J Prokopowicz

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

,

W Szalaj

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

,

N Wolosowicz

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

,

W Laszewicz

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

,

M Szmitkowski

¹Institute of Medicine, Gastrology Clinic, Institute of Physiology and Biochemistry, Department of Clinical Biochemistry Medical School, Bialystok (Poland)

› Institutsangaben

Abstract

Summary

The coagulation and fibrinolytic systems have been investigated in the dogs treated intravenously with secretin, pancreozymin and CCK.

There was significant shortening of plastic and glass clotting times, a fall in blood platelet numbers, prolongation of the prothrombin time, and a transitory inhibition of plasma euglobulin fibrinolytic activity. The greatest changes were found after CCK.

It should be stressed that the peak changes were earlier and more intense when morphine was given with the hormones.

In the authors’ opinion the present findings support the supposition concerning the role of enzymatic toxemia in hemostatic disturbances seen in acute pancreatitis.

Volltext

Referenzen

References
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The Effect of Exocrine Pancreas Stimulation on the Coagulation and Fibrinolytic System in Dogs[*]

The Effect of Exocrine Pancreas Stimulation on the Coagulation and Fibrinolytic System in Dogs^[*]