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Thromb Haemost 1975; 33(03): 417-425
DOI: 10.1055/s-0038-1647903
National Conference on Thrombosis and Hemostasis, Dallas, Texas, 20.—22. November 1974
Schattauer GmbH

Clinical Correlations[*]

Sean Moore
1   Department of Pathology, McMaster University Medical Centre, Hamilton Ontario Canada L8S 4J9
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Publication History

Received 22 January 1975

Accepted 22 January 1975

Publication Date:
02 July 2018 (online)

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Summary

There are two aspects which are clinically relevant in the relationships among thrombosis and arteriosclerosis. First, the relationship of thrombosis to atherogenesis. Thrombosis is closely related to endothelial injury and there is recent evidence that repeated or continuous endothelial damage leads to the development of all the lesions seen in human atherosclerosis. This occurs in the absence of dietary lipid supplement. The relative importance of the parts played by injury and thrombosis in this process need further delineation. Secondly, established arteriosclerotic disease is associated with thrombosis. This thrombosis is usually mural, seldom occlusive. Embolism by platelet aggregates which has been well described in the retinal and cerebral circulations may affect other vascular territories such as the heart and the kidney. Such a mechanism may explain some cases of otherwise unexplained sudden cardiac death and some cases of hypertension. We need better clinical tools to detect the occurrence of thrombo-embolism and to monitor it’s progress. Measures to modify thrombosis and embolism may be as useful or more useful than those we currently employ in the clinical management of atherosclerotic disease.

* Presented at the National Conference on Thrombosis and Hemostasis, under the auspices of the Council on Thrombosis of the American Heart Association, Dallas, Texas, November, 1974.


 

  • References

  • 1 Allard C, Goulet C, Grondin C. M, Lesperance J, Bourassa M. G. Patency of aortocoronary vein grafts and serum triglycerides; three year follow up study. American Journal of Cardiology 1974; 33: 679
    CrossrefPubMedGoogle Scholar
  • 2 Barboriak J. J, Pintar K, Korns M. F. Atherosclerosis in aortocoronary vein grafts. Lancet 1974; 2: 621
    PubMedGoogle Scholar
  • 3 Beebe H. G, Clark W. F, DeWeese J. A. Atherosclerotic change occurring in an autogenous vein arterial graft. Archives of Surgery 1970; 101: 85
    CrossrefPubMedGoogle Scholar
  • 4 Benson R. L. The present status of coronary arterial disease. Archives of Pathology 1926; 2: 870
    PubMedGoogle Scholar
  • 5 Bieber C. P, Stinson E. B, Shumway N. E, Payne R, Kosek J. Cardiac transplantation in man. 7. Cardiac allograft pathology. Circulation 1970; 41: 753
    CrossrefPubMedGoogle Scholar
  • 6 Bjorkerud S. Atherosclerosis initiated by mechanical trauma in normlipidemic rabbits. Atherosclerosis 1969; 9: 209
    PubMedGoogle Scholar
  • 7 Blair E, Nygren E, Cowley R. A. A spiral wire technique for producing gradually occlusive coronary thrombosis. Journal of Thoracic and Cardiovascular Surgery 1964; 48: 476
    PubMedGoogle Scholar
  • 8 Chapman I. Morphogenesis of occluding coronary artery thrombosis. Archives of Pathology 1965; 80: 256
    PubMedGoogle Scholar
  • 9 Chandler A. B. Mechanisms and frequency of thrombosis in the coronary circulation. Thrombosis Research 1974; 4 (Suppl. 01) 3
    CrossrefPubMedGoogle Scholar
  • 10 Cobb L. A, Alvarez H, Baum R. S. Sudden cardiac death: the role of “primary” ventricular fibrillation. Proceedings of the Association of University Cardiologists Phoenix January 1974
    PubMedGoogle Scholar
  • 11 Constantinides P. Plaque fissures in human coronary thrombosis. Journal of Atherosclerosis Research 1966; 6: 1
    CrossrefPubMedGoogle Scholar
  • 12 Danes B. S. Progeria: a cell culture study on aging. Journal of Clinical Investigation 50 1971; 2000
    CrossrefPubMedGoogle Scholar
  • 13 Davies D. F, Rees B. W. G, Johnson A. P, Elwood P. C, Abernethy M. Food antibodies and myocardial infarction. Lancet 1974; 1: 1012
    PubMedGoogle Scholar
  • 14 DeSa D. J, Moore S. Thrombo-atherosclerotic lesions caused by neonatal umbilical arterial catheterization. Circulation 1974; 50 suppl. III 263. Abstract No. 1014
    CrossrefPubMedGoogle Scholar
  • 15 Dible J. H. Organization of and canalization in arterial thrombosis. Journal of Pathology and Bacteriology 1958; 75: 1
    CrossrefPubMedGoogle Scholar
  • 16 Editoral Vascular disease in patients with renal failure. Lancet I: 967 1974;
    PubMedGoogle Scholar
  • 17 Ejrup B, Hierton T, Moberg A. Atheromatous changes in autogenous vein grafts. Functional and anatomical aspects: Case Report. Acta Clinica Scandinavica 1961; 212: 211
    PubMedGoogle Scholar
  • 18 Friedman M, Van Ben Bovenkamp C. J. The pathogenesis of a coronary thrombus. American Journal of Pathology 1966; 48: 19
    PubMedGoogle Scholar
  • 19 Friedman R. J, Moore S, Singal D. P. Regression of thrombo-atherosclerotic lesions by repeated injections of lymphocytotoxic human serum in normo-lipemic rabbits. Federation Proceedings 1974; 33 (Abstract No. 2332) 623
    PubMedGoogle Scholar
  • 20 Friedman R. J, Moore S, Singal D. P. Repeated endothelial injury and induction of atherosclerosis in normolipemic rabbits by human serum. Laboratory Investigation 1975; 32: 404
    PubMedGoogle Scholar
  • 21 Fulton W. F. M. The Coronary Arteries. Charles C. Thomas (publisher); Springfield, Illinois: 1965: 226
    Google Scholar
  • 22 Goldstein S. Life span of cultured cells in progeria. Lancet 1969; 1: 424
    PubMedGoogle Scholar
  • 23 Goldstein S. Analytical review: the pathogenesis of diabetes mellitus and its relationship to biological aging. Humangenetik 1971; 12: 83
    CrossrefPubMedGoogle Scholar
  • 24 Goldstein S, Niewiarowski S, Singal D. P. Pathological implications of cell aging in vitro. Federation Proceedings 34. 1975
    PubMedGoogle Scholar
  • 25 Hardin N. J, Minick C. R, Murphy G. E. Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid rich diet. III. Effect of repeatedly injected foreign protein in rabbits fed a lipid rich, cholesterol poor diet. American Journal of Pathology 1973; 73: 301
    PubMedGoogle Scholar
  • 26 Harker L. A, Slichter S. J, Scott C. R, Ross R. R. Homocytinemia: Vascular injury and arterial thrombosis. New England Journal of Medicine 1974; 291: 537
    CrossrefPubMedGoogle Scholar
  • 27 Hirsh J. The relevance of tests of platelet function in assessing the antithrombotic effects of drugs. In:Platelets Drugs and Thrombosis. S. Karger; Basel: 1975. In Press
    Google Scholar
  • 28 Hirsh J, Gent M, Genton E. The current status of platelet suppressive drugs in the treatment of thrombosis. Thrombosis et Diathesis Haemorrhagica. In Press 1974
    PubMedGoogle Scholar
  • 29 Isbels L. S, Stewart J. H, Mahony J. F, Sheil A. G. R. Deaths from occlusive arterial disease in renal allograft recipients. British Medical Journal 1974; 3: 552
    CrossrefPubMedGoogle Scholar
  • 30 Kaegi A, Pineo G. F, Shimazu A, Trivedi H, Hirsh J, Gent M. Arteriovenous shunt thrombosis: prevention by sulfinpyrazone. New England Journal of Medicine 1974; 290: 304
    CrossrefPubMedGoogle Scholar
  • 31 Kern W. H, Dermer G. B, Lindesmith G. C. The intimai proliferation in aortic coronary saphenous vein grafts. American Heart Journal 84 1972; 771
    CrossrefPubMedGoogle Scholar
  • 32 Leary T. Coronary spasm as a possible factor in producing sudden death. American Heart Journal 1934; 1935; 10: 338
    CrossrefPubMedGoogle Scholar
  • 33 Lindner A, Charra B, Sherrard D. J, Scribner B.M. Accelerated atherosclerosis in prolonged maintenance hemodialysis. New England Journal of Medicine 1974; 290: 697
    CrossrefPubMedGoogle Scholar
  • 34 Lindner A, Curtis K. Morbidity and mortality associated with long term hemodialysis. Hospital Practice 1974; 9: 143
    PubMedGoogle Scholar
  • 35 Lough J, Moore S. Platelet embolic injury; the healing process. Experimental and Molecular Pathology 1972; 17: 132
    CrossrefPubMedGoogle Scholar
  • 36 Marti M. C, Bonchardy B, Cox J. N. Aorto-coronary by-pass with autogenous saphenous vein grafts; histopathologic aspects. Virchows Archiv Abteilung A Pathologische Anatomie. Pathology 1971; 352: 255
    PubMedGoogle Scholar
  • 37 Martin G. M, Sprague C. A, Epstein C. J. Replicative life spans of cultivated human cells. Effect of donor’s age, tissue and genotype. Laboratory Investigation 1970; 23: 86
    PubMedGoogle Scholar
  • 38 Mathew T. H, Clyne D. H, Nanra R.S, Kincaid-Smith P, Salker B. M, Morris P. J, Marshall V. C. A controlled trial of oral anticoagulants and dipyridamole in cadaveric renal allografts. Lancet 1974; 1: 1307
    PubMedGoogle Scholar
  • 39 Mersereaij W. A, Moore S, Fernandez H. Renal renin in experimental nephrosclerosis. Journal of Pathology 1972; 108: 319
    CrossrefPubMedGoogle Scholar
  • 40 Minick C. R, Alonzo D. R, Starek P.K. The role of endothelial injury in coronary atherosclerosis induced by graft rejection. Circulation 50 1974; Suppl. III 92. Abstract No. 359
    PubMedGoogle Scholar
  • 41 Minick C. R, Murphy G. E. Experimental induction of atheroarteriosclero-sis by the sunergy of allergic injury to arteries and lipid rich diet. II. Effect of repeatedly injected foreign protein in rabbits fed a lipid rich, cholesterol poor diet. American Journal of Pathology 1973; 73: 265
    PubMedGoogle Scholar
  • 42 Mitchell J. R. A, Schwartz C. J. The relation between myocardial lesions and coronary artery disease. II. A selected group of patients with massive cardiac necrosis or scarring.. British Heart Journal 1963; 25: 1
    CrossrefPubMedGoogle Scholar
  • 43 Moore S. The relation of superficial cortical scars of the kidney to aortic atherosclerosis. Journal of Pathology and Bacteriology 1964; 88: 471
    CrossrefPubMedGoogle Scholar
  • 44 Moore S. Hypertension and renal ischemia. Geriatrics 1969; 24: 81
    PubMedGoogle Scholar
  • 45 Moore S. Thrombo-atherosclerosis in normolipemic rabbits; a result of continued endothelial damage. Laboratory Investigation 1973; 29: 478
    PubMedGoogle Scholar
  • 46 Moore S. Thrombosis and atherosclerosis. Thrombosis et Diathesis Haemorrhagica Suppl. 1974; 60: 205
    PubMedGoogle Scholar
  • 47 Moore S, Gent M. Plasma renin activity in experimental nephrosclerosis and hypertension. Circulation 1972; 46 (Suppl. 11) 276
    CrossrefPubMedGoogle Scholar
  • 48 Moore S, Lough J. Lipid accumulation in renal arterioles due to platelet aggregate embolism. American Journal of Pathology 58 1970; 283
    PubMedGoogle Scholar
  • 49 Moore S, Mersereau W. A. Platelet embolism and renal ischemia. Journal of Pathology and Bacteriology 1965; a 90: 579
    CrossrefPubMedGoogle Scholar
  • 50 Moore S, Mersereau W. A. Micro-embolic renal ischemia with hypertension. Canadian Medical Association Journal 92: 221 1965; b
    PubMedGoogle Scholar
  • 51 Mustard J. F. The role of platelets and the blood. In: Symposium. The relationship between arteriosclerosis and thrombogenesis (Rokitansky Revisited) National Conference on Thrombosis and Hemostasis. 1974
    PubMedGoogle Scholar
  • 52 O’Reilly R. J, Spellberg R. D. Rapid resolution of coronary arterial emboli; myocardial infarction and subsequent normal coronary arteriograms. Annals of Internal Medicine 81 1974; 348
    CrossrefPubMedGoogle Scholar
  • 53 Porter K. A, Rendall J. M, Solinski C, Terasaki P. I, Marchioro T. L, Starzl T. F. Light and electron microscopical study from thirty three human renal allografts and an isograft 1¾-2½ years after transplantation. Annals of the New York Academy of Science 1966; 129: 615
    PubMedGoogle Scholar
  • 54 Poston R. N, Davies D. F. Immunity and inflammation in the pathogenesis of atherosclerosis. Atherosclerosis 1974; 19: 353
    CrossrefPubMedGoogle Scholar
  • 55 Saphir O, Gore I. Evidence for an inflammatory basis for coronary atherosclerosis in the young. Archives of Pathology 1950; 49: 418
    PubMedGoogle Scholar
  • 56 Saphir O, Priest W. J, Hamburger W. W, Katz L. N. Coronary arteriosclerosis, coronary thrombosis and the resulting myocardial changes. An evaluation of their respective clinical pictures including the electrocardiographic records, based on their anatomical findings.. American Heart Journal 1935; 10: 567-762.
    CrossrefPubMedGoogle Scholar
  • 57 Snow P. J. D, Morgan-Jones A, Daber K. S. Coronary disease; a pathological study. British Heart Journal 17 1955; 503
    CrossrefPubMedGoogle Scholar
  • 58 Stehebns W. E. Haemodynamic production of lipid deposition, intimai tears, mural dissection and thrombosis in the blood vessel wall. Proceedings of the Royal Society London. B 185 1974; 357
    CrossrefPubMedGoogle Scholar
  • 59 Szilagyi D. E, Elliot J. P, Hagermann J. P, Smith R. F, Dall’olmo C. A. Biological fate of autogenous vein implants as arterial substrates. Clinical, angiographic and histopathologic observations in femoropopliteal operations for atherosclerosis. Annals of Surgery 1973; 178: 232
    CrossrefPubMedGoogle Scholar
  • 60 Taylor H. E. Pathology of organ transplantation. Pathology Annual 1972; 7: 173
    PubMedGoogle Scholar
  • 61 Thompson J. G. Production of severe atheromata in a transplanted heart. Lancet 2 1969; 1088
    PubMedGoogle Scholar
  • 62 Voldaver Z, Edwards J. E. Pathologic changes in aortic-coronary arterial saphenous vein grafts. Circulation 1971; 44: 719
    CrossrefPubMedGoogle Scholar
  • 63 Weisse A. B, Leham P. H, Ettinger P. O, Moschos C. B, Regan T. S. The fate of experimentally induced coronary artery thrombosis. American Journal of Cardiology 1969; 23: 229
    CrossrefPubMedGoogle Scholar
  • 64 Wu K. K, Hoak J. C. A new method for the quantitative detection of platelet aggregates in patients with aortic insufficiency. Lancet 1974; 2: 924
    PubMedGoogle Scholar
  • 65 Zeek P. Studies in atherosclerosis. American Journal of Medical Science 1932; 184: 350-356.
    CrossrefPubMedGoogle Scholar