The Effects of Brinolase (Fibrinolytic Enzyme from Aspergillus Oryzae) on Platelet Aggregation of Dog and Man

W. H. E Roschlau; R Gage

doi:10.1055/s-0038-1649039

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(01): 031-048
DOI: 10.1055/s-0038-1649039

Original Article

Schattauer GmbH

The Effects of Brinolase (Fibrinolytic Enzyme from Aspergillus Oryzae) on Platelet Aggregation of Dog and Man

W. H. E Roschlau

¹Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

,

R Gage

¹Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

› Author Affiliations

Abstract

Summary

Inhibition of blood platelet aggregation by brinolase (fibrinolytic enzyme from Aspergillus oryzae) has been demonstrated with human platelets in vitro and with dog platelets in vivo and in vitro, using both ADP and collagen as aggregating stimuli. It is suggested that the optimal inhibitory effects of brinolase occur indirectly through the generation of plasma fibrinogen degradation products, without compromising platelet viability, rather than by direct proteolysis of platelet structures.

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References

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