Thromb Haemost 1973; 30(03): 597-601
DOI: 10.1055/s-0038-1649138
Original Article
Schattauer GmbH

The in Vivo and in Vitro Effect of Antihistamines on Platelet Aggregation

Peter C. Ungaro
1   Division of Hematology, University of Utah Medical Center, Salt Lake City, Utah
,
Thomas M. Beck
1   Division of Hematology, University of Utah Medical Center, Salt Lake City, Utah
,
William M. McCaa
1   Division of Hematology, University of Utah Medical Center, Salt Lake City, Utah
,
Edward J. Hershgold
1   Division of Hematology, University of Utah Medical Center, Salt Lake City, Utah
› Institutsangaben
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Publikationsverlauf

Received 04. Juli 1973

Accepted 21. August 1973

Publikationsdatum:
30. Juni 2018 (online)

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Summary

The effect of antihistamines on platelet aggregation was studied by examining the platelet rich plasma of subjects taking three representative classes of these drugs, as well as by studying the effect of direct addition of antihistamine to platelet rich plasma. Inhibition of aggregation by in vitro addition was obtained only with drug concentrations much greater than would usually be found in vivo. Platelet aggregation was unimpaired in normal volunteers taking standard doses of antihistamines.