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Thromb Haemost 1966; 15(03/04): 413-419
DOI: 10.1055/s-0038-1649442
Originalarbeiten — Original Articles — Travaux Originaux
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Some Effects of Fibrinogen Degradation Products (FDP) on Blood Platelets[*]

Z Jerushalmy
1   American National Red Cross Research Laboratory, Eastern Division, New York; and the Department of Pathology, New York University Medical Center, New York
,
M. B Zucker
1   American National Red Cross Research Laboratory, Eastern Division, New York; and the Department of Pathology, New York University Medical Center, New York
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

“Early” fibrinogen degradation products are more potent inhibitors of thrombin-induced clotting than “late” products and also interfere with the ability of thrombin to release serotonin from platelets. “Early” and “intermediate” FDP cause moderate inhibition of platelet aggregation induced by adenosine diphosphate or connective tissue particles. Serotonin release by connective tissue particles is probably not inhibited by FDP.

* This study was partially supported by Grant# HE-0500:3-06, National Institutes of Health, U.S. Public Health Service.


 

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