Thromb Haemost 1975; 34(02): 513-521
DOI: 10.1055/s-0038-1651410
Original Article
Schattauer GmbH

Studies in Experimental Animals on Disseminated Intravascular Coagulation (DIC)

F Markwardt
1   Institute of Pharmacology and Toxicology and the Institute of General Pathology and Pathological Anatomy, Medical Academy Erfurt, Erfurt (GDR)
,
G Nowak
1   Institute of Pharmacology and Toxicology and the Institute of General Pathology and Pathological Anatomy, Medical Academy Erfurt, Erfurt (GDR)
,
W Meerbach
1   Institute of Pharmacology and Toxicology and the Institute of General Pathology and Pathological Anatomy, Medical Academy Erfurt, Erfurt (GDR)
,
K.-D Rüdiger
1   Institute of Pharmacology and Toxicology and the Institute of General Pathology and Pathological Anatomy, Medical Academy Erfurt, Erfurt (GDR)
› Author Affiliations
Further Information

Publication History

Received 13 January 1975

Accepted 04 May 1975

Publication Date:
02 July 2018 (online)

Summary

Changes in the clotting system, as well as morphological and functional alterations corresponding to that of the pathologic phenomenon of disseminated intravascular coagulation (DIC) or consumption coagulopathy, were produced by thrombin infusion (550 NIH U × kg−1 × h−1) in rats and simultaneous inhibition of fibrinolysis by PAMBA (100 mg/kg).

Changes in the fibrinogen level and platelet count as well as the appearance of fibrin monomers and the formation of microthrombi in several organs were evaluated. Simultaneously, the function of the respiratory system was investigated by continuous measurement of oxygen consumption as well as elasticity and water content of the lung. From the time course of the alterations in the several parameters, conclusions can be drawn for the pathogenesis and the possible therapeutic influence on DIC.

 
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