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Thromb Haemost 1977; 38(03): 0652-0659
DOI: 10.1055/s-0038-1651880
DOI: 10.1055/s-0038-1651880
Original Article
Megakaryocytes in the Giant Platelet Syndrome
A Cytochemical and Ultrastructural StudyAuthors
Further Information
Publication History
Received
15 December 1976
Accepted
14 June 1977
Publication Date:
04 July 2018 (online)
Summary
When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes also showed decreased glycogen and RNA (ribosomes) as well as aberrations of nuclear lobulation.
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References
- 1 Alfert M, Geschwind II. 1953; A selective method for the basic proteins of cell nuclei. Proceedings of the National Academy of Sciences, USA 39: 991.
- 2 Baadenhuusen H, Hirschhauser C, Kurstjens P, Ewals M, Haanen C. 1971; Metabolic observations on platelets from patients with familial thrombopathic thrombocytopenia. British Journal of Haematology 20: 417.
- 3 Bernard J, Soulier J. P. 1948; Sur une nouvelle varíete de dystrophie thrombocytaire hemorrhagipare congenitale. Semaine des hôpitaux de Paris 24: 3217.
- 4 Bessis M. 1973. Living Blood Cells and their Ultrastructure. Springer; New York:
- 5 Bithell T. C, Parekh S. J, Strong P. P. 1972; Platelet function studies in the Bernard-Soulier syndrome. Annals of the New York Academy of Sciences 201: 145.
- 6 Black M. M, Ansley H. R. 1965; Antigen-induced changes in lymphoid cell histones, I. Thymus. Journal of Cell Biology 26: 201.
- 7 Cullum C, Conney D. P, Schrier S. L. 1967; Familial thrombocytopenic thrombocytopathy. British Journal of Haematology 13: 147.
- 8 Dacie J. V, Lewis S. M. 1968. Practical Haematology. 4. Grune and Stratton; New York.:
- 9 Grottum K. A, Solum N. O. 1969; Congenital thrombocytopenia with giant platelets: a defect in the platelet membrane. British Journal of Haematology 16: 277.
- 10 Hayhoe F. G. J, Quaglino D, Doll D. 1964. The Cytology and Cytochemistry of Acute Leukaemias. MRC Special Reports Series #304. HM Stationery Office; London.:
- 11 Heggelin R. 1945; Über eine neue Form einer konstitutionellen Leukozyten-Anomalie, kombiniert mit Thrombopathie. Archiv der Julius Klaus-Stiftung für Vererbungsforschung, Sozialanthropologie und Rassenhygiene 20: 1.
- 12 Hirsch E. O, Favre-Gilly J, Dameshek W. 1950; Thrombopathic thrombocytopenia: successful transfusion of blood platelets. Blood 5: 568.
- 13 Howard M. A, Hutton R. A, Hardisty R. M. 1973; Hereditary giant platelet syndrome: a disorder of a new aspect of platelet function. Medical British Journal II: 586.
- 14 Kass. 1974; Megakaryocytes in the May-Heggelin anomaly. Archives of Pathology 98: 112.
- 15 Kass L, Hadi M. Z. 1975; Phosphorylase activity in chronic erythremic myelosis. American Journal of Clinical Pathology 64: 503.
- 16 Kurstjens R, Bolt C, Vossen M, Haanen F. 1968; Familial thrombopathic thrombocytopenia. British Journal of Haematology 15: 305.
- 17 Larrain C, Etchenverry R. 1962; Thrombopenia thromobopatica familiar. Revista médica de Chile 90: 192.
- 18 Maldonado J. E, Gilchrist G. S, Bridgen L. P, Bowie E. J. 1975; Ultrastructure of platelets in Bernard-Soulier syndrom. Mayo Clinic Proceedings 50: 402.
- 19 May R. 1909; Leukozyteneinschlüsse. Deutsches Archiv für klinische Medizin 96: 1.
- 20 Niewiarowski S, Poplawski A, Prokopowicz J. et al. 1969; Abnormalities of platelet function and ultrastructure in macrothrombocytic thrombopathia. Scandinavian Journal of Haematology 6: 311.
- 21 Pavlovsky A, DeTazanos Pinto M, Martinez Canaveri A. et al. 1967; A propos d’un cas de thrombopathie hemorrhagique congenitale (etude au microscope electronique). Nouvelle revue française d’hématologie 7: 559.
- 22 Quick A. J, Hussey C. V. 1963; Hereditary thrombopathic thrombocytopenia. American Journal of Medical Science 245: 643.
- 23 Reynolds E. S. 1963; The use of lead citrate at high pH as an electron opaque stain in electron microscopy. Journal of Cell Biology 17: 208.
- 24 Schnitzer B, Kass L. 1973; Leukemic phase of reticulum cell sarcoma (histiocytic lymphoma). A clinicopathologic and ultrastructural study. Cancer 31: 547.
- 25 Stuart J, Skowron P. N. 1968; A cytochemical study of marrow enzymes in megaloplastic anaemia. British Journal of Haematology 15: 443.
- 26 Thompson S. W, Hunt R. D. 1966. Selected Histochemical and Histopathological Methods. Thomas; Springfield.:
- 27 Yam L. T, Li C. Y, Crosby W. H. 1971; Cytochemical identification of monocytes and granulocytes. American Journal of Clinical Pathology 55: 283.