Malondialdehyde Production by Platelets during Secondary Aggregation

D. E Macfarlane; Sheila Gardner; Carol Lipson; D. C. B Mills

doi:10.1055/s-0038-1651918

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 38(04): 1002-1009
DOI: 10.1055/s-0038-1651918

Original Article

Schattauer GmbH

Malondialdehyde Production by Platelets during Secondary Aggregation

Authors

D. E Macfarlane

¹Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
Sheila Gardner

¹Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
Carol Lipson

¹Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.
D. C. B Mills

¹Specialized Center for Thrombosis Research, Temple University Hospital, 3401 North Broad Street, Philadelphia, Pennsylvania, 19140, U.S.A.

Abstract

Summary

A method is described for increasing the sensitivity of the thiobarbiturate assay for malondialdehyde by concentrating the coloured reaction product. The basal level of malondialdehyde-like material in plasma was found to be about 0.03 μM. Platelets synthesized malondialdehyde when stimulated by collagen or thrombin and also during the second phase of aggregation induced by ADP or adrenaline.

Full Text

References

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