Platelet Changes Induced by Elatericin A

H Joshua; B Shohat; I Cohen; S Gitter

doi:10.1055/s-0038-1653544

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1969; 21(02): 346-353
DOI: 10.1055/s-0038-1653544

Originalarbeiten - Original Articles - Travaux Originaux

Schattauer GmbH

Platelet Changes Induced by Elatericin A

Authors

H Joshua

¹Department of Pharmacology, Tel-Aviv University Medical School, The Rogoff-Wellcome Medical Research Institute, and the Clinical Laboratory, Beilinson Hospital, Petah-Tikva
B Shohat

¹Department of Pharmacology, Tel-Aviv University Medical School, The Rogoff-Wellcome Medical Research Institute, and the Clinical Laboratory, Beilinson Hospital, Petah-Tikva
I Cohen

¹Department of Pharmacology, Tel-Aviv University Medical School, The Rogoff-Wellcome Medical Research Institute, and the Clinical Laboratory, Beilinson Hospital, Petah-Tikva
S Gitter

¹Department of Pharmacology, Tel-Aviv University Medical School, The Rogoff-Wellcome Medical Research Institute, and the Clinical Laboratory, Beilinson Hospital, Petah-Tikva

Abstract

Summary

Elatericin A at a concentration of 3 μg/ml causes spicule formation on platelets and inhibits spreading on glass surfaces, viscous metamorphosis and clot retraction. Elatericin A has no effect whatsoever on the activity of isolated platelet factors. However platelet factor 3-availability is decreased by elatericin A. Platelets treated with elatericin A up to a limiting concentration of 30 μg/ml regain their clot retracting activity if washed and reincubated in normal plasma.

Elatericin A does not affect the ATP content nor the ATPase activity of platelets. A normal ADP-release is obtained upon addition of thrombin to elatericin A treated platelets. Addition of ATP and Mg ions does not restore the clot retracting activity of elatericin A treated platelets.

Full Text

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