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Thromb Haemost 1970; 24(03/04): 562-571
DOI: 10.1055/s-0038-1654267
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Coagulation Studies in 45 Cases of Nephrotic Syndrome without Uremia[*]

A Kanfer
1   Clinique Néphrologique, Clinique de Génétique et Département d’Hématologie, C. H. U. Necker-Enfants Malades, Paris, France
,
D Kleinknecht
1   Clinique Néphrologique, Clinique de Génétique et Département d’Hématologie, C. H. U. Necker-Enfants Malades, Paris, France
,
M Broyer
1   Clinique Néphrologique, Clinique de Génétique et Département d’Hématologie, C. H. U. Necker-Enfants Malades, Paris, France
,
F Josso
1   Clinique Néphrologique, Clinique de Génétique et Département d’Hématologie, C. H. U. Necker-Enfants Malades, Paris, France
› Author Affiliations
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

Coagulation studies were performed in 45 cases of nephrotic syndrome without uremia. The most striking features were an increase in the number of thrombocytes, and in the level of fibrinogen, factor V and factor VIII. Thrombin time was usually prolonged and the titre of antithrombin III was increased. No fibrin breakdown products were found in the serum. 13 patients developed thrombotic complications, with eventual death in 5 cases.

* First results of these studies have been presented at the IVth International Congress of Nephrology (Stockholm, june 1969).


Author’s adress: Dr. A.Kanfer, Département d’Hématologie, C.H.U.Necker - Enfants Malades, Paris XV.


 

  • References

  • 1 Alagille D, Soulier J. P. Le test d’activité plaquettaire du sérum. Rev. franç. Étud. clin, biol 02: 231 1957;
    PubMedSearch in Google Scholar
  • 2 Alagille D, Soulier J. P. Étude du temps de thrombine chez les hépatiques. Rev. int. Hépat 07: 1 1957;
    PubMedSearch in Google Scholar
  • 3 von Dittrich P, Fries R. Untersuchung einiger Gerinnungsfaktoren (Fibrinogen, Antithrombin III und Thrombelastogramm) bei Nierenkrankheiten. Klin. Wschr 43: 390 1965;
    CrossrefPubMedSearch in Google Scholar
  • 4 Egeberg O. Conditions associated with increased blood factor VIII activity. “The hemophilias”. International Symposium. Brinkhous K. M. ed. The University of North Carolina Press; 203.
  • 5 Eisenberg S. Blood volume in persons with the nephrotic syndrome. Amer. J. med. Sci 255: 320 1968;
    CrossrefPubMedSearch in Google Scholar
  • 6 Fisher E. R, Sharrey D, Pardo V, Vuzevshi V. Experimental renal vein constriction. Lab. Invest 18: 689 1968;
    PubMedSearch in Google Scholar
  • 7 Gouault M. Étude critique des méthodes de dorsage de la prothrombine. Dosage de la prothrombine dans le plasma et le sérum, les fractions plasmatiques et les liquides biologiques. Mise en évidence d’une anomalie de la prothrombine chez des sujets traités par les antagonistes de la vitamine K. Thèse (Médecine). Paris: 1967
    Search in Google Scholar
  • 8 Gram H. G. A new method for the determination of the fibrin percentage in blood and plasma. J. biol. Chem 49: 279 1921;
    PubMedSearch in Google Scholar
  • 9 Gross R, Nieth H, Mammen E. Blutungsbereitschaft und Gerinnungsstörungen bei Urämie. Klin. Wschr 36: 107 1958;
    CrossrefPubMedSearch in Google Scholar
  • 10 Larrieu M. J, Weilland G. Utilisation de la “céphaline” dans les tests de coagulation. Rev. Hémat 12: 199 1957;
    PubMedSearch in Google Scholar
  • 11 Morris J. F, Ginn E, Thompson D. D. Unilateral renal vein thrombosis associated with the nephrotic syndrome. Amer. J. Med 34: 867 1963;
    CrossrefPubMedSearch in Google Scholar
  • 12 Richet G, Gillot G, Vaysse J, Meyerovitch A. La thrombose isolée de la veine rénale. Presse méd 73: 2039 1965;
    PubMedSearch in Google Scholar
  • 13 Schultz F. H. Das Fibrinogen. VEB Georg Thieme, Leipzig (1953) 73: 2035 1965;
    PubMedSearch in Google Scholar
  • 14 Soulier J. P, Le Bolloch A. G. Le test de tolérance à l’héparine in vitro. Rev. Hémat 05: 148 1950;
    PubMedSearch in Google Scholar
  • 15 Soulier J. P, Larrieu M. J. Étude analytique des temps de Quick allongés. Dosage de prothrombine, de proconvertine et de proaccélérine. Sang 23: 549 1952;
    PubMedSearch in Google Scholar
  • 16 Soulier J. P, Larrieu M. J. Nouvelle méthode de diagnostic de l’hémophilie. Dosage des facteurs antihémophiliques A et B. Sang 24: 205 1953;
    PubMedSearch in Google Scholar
  • 17 Steinbuch M, Blatrix G. h, Josso F. Action anti-protéase de l’alpha-2-macroglobuline. II. Son rôle d’antithrombine progressive. Rev. franç. Étud. clin. Biol 13: 179 1968;
    PubMedSearch in Google Scholar
  • 18 Stiehm E. R, TrygstacL C. W. Splits products in human renal disease. Amer. J. Med 46: 774 1969;
    CrossrefPubMedSearch in Google Scholar
  • 19 Takeda Y, Chen A. Y. Fibrinogen metabolism and distribution in patients with the nephrotic syndrome. J. Lab. clin. Med 70: 678 1967;
    PubMedSearch in Google Scholar
  • 20 Todd M. E. Coagulation studies in patients with the nephrotic syndrome and the uremic state. Xlth Congress of International Society of Haematology (abstract). 239 Sidney: 1966
    Search in Google Scholar
  • 21 Wardle E. N, Taylor G. Fibrin breakdown products and fibrinolysis in renal disease. J. clin. Path 21: 140 1968;
    CrossrefPubMedSearch in Google Scholar
  • 22 Worowski K. The hypercoagulability in mercury chloride intoxicated dogs. Thrombos. Diathes. haemorrh. (Stuttg) 19: 236 1968;
    PubMedSearch in Google Scholar
  • 23 Worowski K, Niewiarowski S, Prokopowicz J. Fibrinolysis and fibrinogen breakdown products (antithrombin VI) in renal venous blood in dogs. Thrombos. Diathes. haemorrh. (Stuttg) 12: 87 1964;
    PubMedSearch in Google Scholar
  • 24 Yatzidis H, Richet G. Activité de certaines protéines de la coagulation dans le plasma et les urines au cours du syndrome néphrotique. Rev. franç. Étud. clin. Biol 02: 717 1957;
    PubMedSearch in Google Scholar