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DOI: 10.1055/s-0038-1654374
Some Aspects of Kinetics of the First Stages of Blood Thromboplastin Formation
Authors
Publication History
Publication Date:
08 June 2018 (online)
Summary
The first stages of blood thromboplastin generation were investigated. Plasma Thromboplastin Antecedent, Prephase Accelerator, and Hageman factor are involved in the reactions taking place during the lag period. This phase is followed by the formation of intermediate product I. Studying the kinetics of this particular reaction it was possible to attribute to factors VIII and IX the rôle of substrates and to Stuart-Prower factor the rôle of an enzyme. It appears that in haemophilia B serum two distinct factors are lacking, the genuine factor IX, and the prephase accelerator (PPA). An hypothesis explaining tentatively the activation of a precursor to PPA and genuine factor IX is offered.
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References
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- 2 Bergsagel D. E, Biggs R. The Christmas Factor. Rev. hémat 1955; 10: 354
- 3 Bergsagel D. E, Hougie C. Intermediate Stages in the Formation of Blood Thromboplastin. Brit. J. Haemat 1956; 2: 113
- 4 Biggs R, Douglas A. S. The Thromboplastin Generation Test. J. clin. Pathol 1953; 6: 23
- 5 Duckert F, Flückiger P, Isenschmid H, Matter M, VogelMeng J, Koller F. A Modification of the Thromboplastin Generation Test. Acta haemat 1954; 12: 197
- 6 Fisch U. Über einen neuen Accelerator der Blutthrombokinasebildung. Thromb. Diath. haem 1958; 2: 60
- 7 Geiger M, Duckert F, Koller F. (1956)Quantitative Bestimmungen von F. VIII und F. IX bei Blutersippen. Kongr. Europ. Ges. Haemat. 1955. Verlag Heidelberg; Springer:
- 8 Hougie C. The Role of Factor V in the Formation of Blood Thromboplastin. J. Lab. clin. Med 1957; 50: 61
- 9 Koller F, Loeliger A, Duckert F. Experiments on a new Clotting Factor (Factor VII). Acta haemat 1951; 6: 1
- 10 Ratnoff O. D, Colopy J. E. A Familiar Hemorrhagic Trait Associated with a Deficiency of a Clot-promoting Fraction of Plasma. J. clin. Invest 1955; 34: 602
- 11 Rosenthal R, Dreskin O. H, Rosenthal N. New Hemophilia like Disease Caused by Deficiency of a Third Plasma Thromboplastin Factor. Proc. Soc. exptl. Biol. Med 1953; 82: 171
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References
- 1 Bachmann F, Duckert F, Koller F. The Stuart-Prower factor assay and its Clinical Signification. Thromb. Diath. haem 1958; 2: 24
- 2 Bergsagel D. E, Biggs R. The Christmas Factor. Rev. hémat 1955; 10: 354
- 3 Bergsagel D. E, Hougie C. Intermediate Stages in the Formation of Blood Thromboplastin. Brit. J. Haemat 1956; 2: 113
- 4 Biggs R, Douglas A. S. The Thromboplastin Generation Test. J. clin. Pathol 1953; 6: 23
- 5 Duckert F, Flückiger P, Isenschmid H, Matter M, VogelMeng J, Koller F. A Modification of the Thromboplastin Generation Test. Acta haemat 1954; 12: 197
- 6 Fisch U. Über einen neuen Accelerator der Blutthrombokinasebildung. Thromb. Diath. haem 1958; 2: 60
- 7 Geiger M, Duckert F, Koller F. (1956)Quantitative Bestimmungen von F. VIII und F. IX bei Blutersippen. Kongr. Europ. Ges. Haemat. 1955. Verlag Heidelberg; Springer:
- 8 Hougie C. The Role of Factor V in the Formation of Blood Thromboplastin. J. Lab. clin. Med 1957; 50: 61
- 9 Koller F, Loeliger A, Duckert F. Experiments on a new Clotting Factor (Factor VII). Acta haemat 1951; 6: 1
- 10 Ratnoff O. D, Colopy J. E. A Familiar Hemorrhagic Trait Associated with a Deficiency of a Clot-promoting Fraction of Plasma. J. clin. Invest 1955; 34: 602
- 11 Rosenthal R, Dreskin O. H, Rosenthal N. New Hemophilia like Disease Caused by Deficiency of a Third Plasma Thromboplastin Factor. Proc. Soc. exptl. Biol. Med 1953; 82: 171