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Thromb Haemost 1960; 4(02): 196-200
DOI: 10.1055/s-0038-1654496
DOI: 10.1055/s-0038-1654496
Originalarbeiten — Original Articles — Travaux Originaux
Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis[*]
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. Juni 2018 (online)
Summary
The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed.
* This investigation was supported by the Netherlands Organization for Applied Scientific Research (T.N.O.).
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References
- (1) Astrup T, Claassen M. The fibrinolytic and thromboplastic activities of the arterial wall. Proc, europ. Soc. Haemat. (Copenhagen) 2: 455 1957;
- (2) Boivin J. M. Infarctus du myocarde chez un hémophile. Arch. Mal. Coeur 47: 351-354 1954;
- (3) Borchgrevink Chr. F. Myocardial infarction in a haemophiliac. Lancet I: 1229-1230 1959;
- (4) Duguid J. B. Mural thrombosis in arteries. Brit. med. J. 11: 36-38 1955;
- (5) Esch B. v. d. Thesis. To be published in 1960.
- (6) Frick P. G. Studies on the turnover rate of stable prothrombin conversion factor in man. Acta haemat. 19: 20-29 1958;
- (7) Koller F. Der heutige Stand der Gerinnungsforschung. Thromb. diath. haem. 2: 407-427 1958;
- (8) Loeliger E. A. Methoden zur Kontrolle der Antikoagulantienwirkung. Thromb. diath. haem. 2: 441-461 1958;
- (9) Loeliger E. A. Schlechte Eigenschaft langwirkender Cumarine oder für deren Kontrolle ungeeignete Thrombokinase?. Schweiz, med. Wschr. 88: 639-643 1958;
- (10) Loeliger E. A, Esch B. V. D, Cleton F. J, Booij H. L. On the metabolism of the coagulation factor VII. Proc. europ. Soc. Haemat.. 1959
- (11) Loeliger E. A, ter Haar Romeny-Wachter C. Ch, Moojen E. J. Unpublished results.
- (12) O’Brien J. R. Personal communication. 7th Europ. Congr. Haemat.. London: 1959
- (13) Stewart J. W, Acheson E. D. Atherosclerosis in a haemophiliac. Lancet I: 1121-1122 1957;
- (14) Witte S. Die Beziehungen zwischen Thromboplastin und Hyaluronidase. Proc, europ, Haemat. (Freiburg) 1: 615-616 1955;
- (15) Witte S, Bressel D. Über die Thrombokinaseaktivität der Blutgefäße. Folia haemat., N. F. 2: 236 1958;
- (16) Witte S, Bressel D. Über die Aktivitätssteigerung der Thrombokinase in Blutgefäßwänden durch Hyaluronidase. Thromb. diath. haem. 3: 76 1959;