ADP-Induced Platelet Adhesiveness as a Diagnostic Test in von Willebrand’s Disease)

Summary

In von Willebrand’s disease the ADP-induced platelet adhesiveness in plasma is zero at a final concentration of 0.05 µg/ml. Several coagulopathies react as normals giving a detectable platelet adhesiveness ranging from 18% to 44%. This may be used as a diagnostic test in von Willebrand’s disease.

• References

• Caen J, Cousin C. Le trouble d’adhesivité in vivo des plaquettes dans la maladie de Willebrand et les thrombasthenies de Glanzmann. Nouv. Rev. franç. Hémat. 02: 685 1962;
• Gaarder A. M, Jonsen J, Laland S, Hellem A. J, Owren P. A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature 192: 531 1961;
• Hellem A. J. The adhesiveness of human blood platelets in vitro. Thesis. Scand. J. clin. Lab. Invest 12 Suppl. 51 1960;
• Jürgens R, Schulz H. Thrombocytenfunktionsbestimmungen mit Sequestren. Die Ultrastruktur der Thrombocyten. VII Congr. int. Soc. Hemat., Rome. 1958 communication no. 318.
• Nilsson I. M, Blombäck M, Jorpes E, Blombäck B, Johansson S. A. von Willebrand’s disease and its correction with human plasma fraction 1-0. Acta med. scand. 159: 179 1957;
• Salzmann E. W. Measurement of platelet adhesiveness. J. Lab. clin. Med. 62: 724 1963;
• Ulutin O. N, Karaca M. A study on the pathogenesis of thrombopathia using the “platelet osmotic resistance test”. Brit. J. Haemat. 05: 302 1959;
• Vainer H, Caen J. Utilisation d’un test photométrique pour l’étude de l’effet de l’ADP sur les plaquettes sanguines. Nouv. Rev. franç. Hémat. 03: 149 1963;
• Zucker M. B. In vitro abnormality of the blood in von Willebrand’s disease correctable by normal plasma. Nature 197: 601 1963;