Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1967; 18(03/04): 425-432DOI: 10.1055/s-0038-1655051 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Uroplastin, Its Nature and Its Excretion Pattern in Health and in Certain Disease States Authors Author Affiliations H Joist M. D. * 1 Department of Internal Medicine, Washington University, St. Louis, Missouri Norma Alkjaersig Ph. D. 1 Department of Internal Medicine, Washington University, St. Louis, Missouri Recommend Article Abstract Buy Article(opens in new window) Summary Experimental studies with a partially purified, potent procoagulant from human urine are reported. The material having the electrophoretic property of a â-globulin appears to functionally closely resemble tissue thromboplastin. A significant difference in the excretion of this pro coagulant between normal males and females and deviations from the normal excretion pattern in patients with impaired kidney function and certain other disease states are demonstrated. Possible pathophysiological implications of these findings are discussed. Full Text References References 1 Grunke W. Studien über die Blutgerinnung mit besonderer Berücksichtigung der Hämophilie. I. Mitteilung. Einfluß des Harnes auf die Gerinnung hämophilen Blutes. Z. ges. exp. Med. 96: 512 1935; 2 Tocantins L. M, Lindquist J. N. Thromboplastic activity of the urine. Fed. Proc. 06: 215 1947; 3 von Kaulla K. N. Methods for preparation of purified human thromboplastin and fibrinolysokinase from urine. Actahaemat. (Basel) 16: 315 1956; 4 Caldwell M. J, von Kaulla K. N, von Kaula E, Seegers W. H. Procoagulant material from human urine in prothrombin activation. Thrombos. Diathes. haemorrh. (Stuttg) 09: 53 1963; 5 von Kaulla K. N, von Kaulla E. Inactivation of pathological inhibitors of intrinsic thromboplastin by procoagulant from human urine. Acta haemat. (Basel) 30: 25 1963; 6 AoTci N, v. Kaulla K. N. The procoagulant in human urine: Purification, assay and some biochemical and physiological properties. Thrombos. Diathes. haemorrh. (Stuttg) 16: 586 1966; 7 Alkjaersig N, Fletcher A. P, Sherry S. The assay of urokinase preparations for contamination with thromboplastic moieties. J. Lab. clin. Med. 65: 732 1965; 8 Smyrnoitis F. E, Fletcher A. P, Alkjaersig N, Sherry S. Urokinase excretion in health and its alteration in certain disease states. Thrombos. Diathes. haemorrh. (Stuttg) 03: 257 1959; 9 Smithies O. An improved procedure for starch gel electrophoresis: further variations in the serum proteins of normal individuals. Biochem. J. 71: 585 1959; 10 Bachmann F, Duckert F, Koller F. The Stuart factor assay and its clinical significance. Thrombos. Diathes. haemorrh. 02: 24 1958; (Stuttg.). 11 Ferguson J. H. Thromboplastic enzymes. Fed. Proc. 23: 762 1964; 12 Matsumura T, von Kaulla K. N. Reduced excretion of urinary procoagulant in uremic patients. Experientia (Basel) 22: 318 1966;
