Thromb Haemost 1967; 18(03/04): 525-531
DOI: 10.1055/s-0038-1655061
Originalarbeiten — Original Articles — Travaux Originaux
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Contact Activation in the Extrinsic Blood Clotting System

R Altman*
1   Haematology Section of the Department of Internal Medicine, University Hospital, Leyden (The Netherlands)
,
H. C Hemker
1   Haematology Section of the Department of Internal Medicine, University Hospital, Leyden (The Netherlands)
› Author Affiliations
Further Information

Publication History

Publication Date:
26 June 2018 (online)

Summary

After contact activation, factor XII can convert factor VII into its active form. Factor XI enhances this action but appears not to be a compulsatory part of the system. The short circuit of the intrinsic system constituted by this pathway may be important in triggering the intrinsic coagulation system.

* Present address: Rivadavia Hospital, Buenos Aires, Argentina.