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Hamostaseologie 1985; 05(05/06): 200-208
DOI: 10.1055/s-0038-1655129
Originalarbeiten
Schattauer GmbH

Einfluß von unfraktioniertem Heparin auf die Plättchenfunktion und primäre Hämostase[*]

D. Heinrich
1   Zentrum für Innere Medizin am Klinikum der Universität Gießen (Geschäfts! Direktor: Prof. Dr. Dr. h. c. H. G. Lasch)
,
R. Hanusch   **
1   Zentrum für Innere Medizin am Klinikum der Universität Gießen (Geschäfts! Direktor: Prof. Dr. Dr. h. c. H. G. Lasch)
,
D. G. S. Thilo-Körner
1   Zentrum für Innere Medizin am Klinikum der Universität Gießen (Geschäfts! Direktor: Prof. Dr. Dr. h. c. H. G. Lasch)
› Author Affiliations
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Publication Date:
22 June 2018 (online)

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* Herrn Prof. Dr. Dr. h. c. H. G. Lasch zum 60. Geburtstag gewidmet.


** Wesentliche Teile dieser Arbeit sind Bestandteil der Dissertationsarbeit von R. Hanusch.


 

  • LITERATUR

  • 1 Rosenberg R. D. Actions and interactions of antithrombin and heparin. New Engl. J. Med. 292: 146-151 1975;
    CrossrefPubMedGoogle Scholar
  • 2 Babcock R. B, Dumper C. W, Scharfman W. B. Heparin-induced immune thrombocytopenia. New Engl. J. Med. 295: 237-241 1976;
    CrossrefPubMedGoogle Scholar
  • 3 Cimino R. L, Moake J. L, Weininger R. S, Ben-Menachem Y, Khalil K. G. Amer. J. Haematol. 06: 125-133 1979;
    CrossrefPubMedGoogle Scholar
  • 4 Rhodes G. R, Dixon R. H, Silver D. Heparin-induced thrombocytopenia: Eight cases with thrombotic-hemorrhagic complication. Ann. Surg. 186: 752-758 1977;
    CrossrefPubMedGoogle Scholar
  • 5 Besterman E. M. M, Gillett M RT. Heparin effects on plasma lysolecithin formation and platelet aggregation. Atherosclerosis 17: 503-513 1973;
    CrossrefPubMedGoogle Scholar
  • 6 O’Brien J. H, Shoobridge S. M, Finch W. J. Comparison of the effect of heparin and citrate on platelet aggregation. J. Clin. Path. 22: 28-31 1969;
    CrossrefPubMedGoogle Scholar
  • 7 Thomson C, Forbes D. C, Prentice C. R. M. The potentiation of platelet aggregation and adhesion by heparin in vitro and in vivo. Clin. Sci. Mol. Med. 45: 485-494 1973;
    PubMedGoogle Scholar
  • 8 Eika C. Platelet refractory state induced by heparin. Scand. J. Haemat. 09: 665-672 1972;
    PubMedGoogle Scholar
  • 9 Beck E. Effects of heparin on platelet reactivity in citrated plasma. Thrombos. Haemostas 38: 578-580 1977;
    PubMedGoogle Scholar
  • 10 Mastacchi R, Stanzani L, Barbanti M, Montecchi L, Bianchini P. Interaction of heparin and fractions with human platelets. Thromb. Res. 28: 275-280 1982;
    CrossrefPubMedGoogle Scholar
  • 11 Salzman E. W, Rosenberg R. D, Smith M. H, Lindon J. N, Favreau L. Effect of heparin and heparin fractions on platelet aggregation. J. Clin. Invest. 65: 64-73 1980;
    CrossrefPubMedGoogle Scholar
  • 12 Praga C. Standardized bleeding time in the study of drugs interferring with platelet function. Adv. Exp. Med. Biol. 34: 149-158 1972;
    PubMedGoogle Scholar
  • 13 Born G. V. R. Quantitative investigations into the aggregation of blood platelets. J. Physiol. 162: 67-77 1962;
    PubMedGoogle Scholar
  • 14 Born G. V. R, Cross M. J. The aggregation of blood platelets. J. Physiol. 168: 178-195 1963;
    CrossrefPubMedGoogle Scholar
  • 15 Heinrich D, Gutschank S, MuellerEckhardt C. HLA-Antibody-induced 14c-serotonin release from platelets. A methodological analysis. Vox. Sang. 33: 65-78 1977;
    PubMedGoogle Scholar
  • 16 Röka L. Anwendung chromogener Substrate zur Bestimmung von Heparin-Kofaktor (Antithrombin III) und Heparin. Krankenhausarzt. 52: 871-879 1979;
    PubMedGoogle Scholar
  • 17 Gladke E, von Hattingberg H. M. Pharmakokinetik. Eine Einführung. Springer, Berlin Heidelberg New York: 1973: 39-43.
    Google Scholar
  • 18 Biggs R. In: Human Blood Coagulation, Haemostasis and Thrombosis. Blackwell Scientific; Oxford: 1972
    Google Scholar
  • 19 Quick A. J, Schanberg J. N, Stefanini M. The effect of heparin on platelets in vivo. J. Lab. Clin. Med. 33: 1424-1430 1948;
    PubMedGoogle Scholar
  • 20 Borchgrevink C. E. The mechanism of the prolonged bleeding time provoked by dextran sulfate or by excessive doses of heparin. Acta Med. Scand. 170: 365-373 1961;
    PubMedGoogle Scholar
  • 21 Heiden D, Mielke C. H, Rodvien R. Impairment by heparin of primary haemostasis and platelet 14C-5-hydroxytryptamin release. Brit. J. Haematol. 36: 427-436 1977;
    CrossrefPubMedGoogle Scholar
  • 22 Gillett M. P. T, Besterman E. M. M. Effects of heparin derived from different tissues on plasma phospholipides and platelet aggregation. Lancet. II: 1204 1973;
    PubMedGoogle Scholar
  • 23 Eika C. On the mechanism of platelet aggregation induced by heparin, protamin and polybrene. Scand. J. Haematol. 09: 248-257 1972;
    PubMedGoogle Scholar
  • 24 Zucker M. G. Heparin and platelet function. Fed. Proc. 36: 47-49 1977;
    PubMedGoogle Scholar
  • 25 Heinrich D. (unveröffentlichte Mitteilung).
    PubMed
  • 26 Shanberge J. N, Kambayashi J, Nakagawa M. The interaction of platelets with a tritium-labeled heparin. Thromb. Res. 09: 595-601 1976;
    CrossrefPubMedGoogle Scholar
  • 27 Lindon J. N, Brier-Russell D, Silane M, Smith M. H, Labarre D, Dincer A, Rosenberg R. D, Merrill E, Salzman E. W. Heparin-coated surfaces that bind antithrombin have reduced platelet reactivity. Thromb. Haemost. 42: 131-136 1979;
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Rosenberg R. D. Heparin-antithrombin system. In: Colman R. W, Hirsh J, Marder V. J, Salzman E. W. (Eds.): Hemostasis and Thrombosis. Lippincott; Philadelphia Toronto: 1982: 962-985.
    Google Scholar
  • 29 Coller B. W, Gralnick H. R. Studies on the mechanism of ristocetin-induced platelet agglutination. Effects of structural modification of ristocetin and vancomycin. J. Clin. Invest. 60: 302-307 1977;
    CrossrefPubMedGoogle Scholar
  • 30 Amsterdam A, Reches A, Amir Y, Mintz Y, Salomon Y. Modulation of adenylcyclase activity by sulfated glycosaminoglycane. II. Effects of mucopolysaccharides and dextran on the activity of adenylate cyclase derived from various tissues. Biochim. Biophys. Acta. 544: 273-283 1978;
    CrossrefPubMedGoogle Scholar
  • 31 Saba H. I, Saba S. R, Blackburn C. A, Hartmann R. C, Mason R. G. Heparin neutralization of PGI2: Effect upon platelets. Science 205: 499-501 1977;
    PubMedGoogle Scholar
  • 32 Eldor A, Weksler B. B. Heparin and dextran sulfate antagonize PGI2 inhibition of platelet aggregation. Thromb. Res. 16: 617-628 1979;
    CrossrefPubMedGoogle Scholar
  • 33 Lewy R. U, Wiener L, Smith J. B, Walinsky P, Silver M. J. Intravenous heparin initiates in vivo synthesis and release of thromboxane in angina pectoris. Lancet II: 97 1979;
    PubMedGoogle Scholar
  • 34 Anderson A, Mohammad W. H, Chuang H. Y. K, Mason R. G. Heparin potentiates synthesis of thromboxane A2 in human platelets. Adv. Prostaglandin Thromboxane Res. 06: 287-291 1980;
    PubMedGoogle Scholar
  • 35 Mohammad S. K, Anderson W. H, Smith J. B, Chuang H. Y. K, Mason R. G. Effects of heparin on platelet aggregation and release and thromboxane A2 production. Amer. J. Pathol. 104: 132-141 1981;
    PubMedGoogle Scholar
  • 36 Ansell J, Slepchuk Jr. N, Kumar R, Copez A, Deykin D. Heparin-induced thrombocytopenia: A prospective study. Haemostasis 43: 61-65 1980;
    Article in Thieme ConnectPubMedGoogle Scholar
  • 37 Bell W. R, Tomasulo P. A, Alving B. M, Duffy R. P. Thrombocytopenia occurring during the administration of heparin. A prospective study in 52 patients. Ann. Intern. Med. 85: 155-160 1976;
    CrossrefPubMedGoogle Scholar
  • 38 Kapsch D. N, Adelstein E. H, Rhodes G. R, Silver D. Heparin-induced thrombocytopenia, thrombosis and haemorrhage. Surgery 86: 148-155 1979;
    PubMedGoogle Scholar
  • 39 Klein H. G, Bell W. R. Disseminated intravascular coagulation during heparintherapy. Ann. Intern. Med. 80: 477-481 1974;
    CrossrefPubMedGoogle Scholar
  • 40 Rhodes G. R, Dixon R. H, Silver D. Heparin-induced thrombocytopenia with thrombotic and hemorrhagic manifestations. Surg. Gynecol. Obstet. 136: 409-416 1973;
    PubMedGoogle Scholar
  • 41 Bell W. R, Anderson N. D, Anderson A. D. Heparin-induced coagulopathy. J. Lab. Clin. Med. 89: 741-750 1977;
    PubMedGoogle Scholar
  • 42 Heinrich D, Schleussner E, Wagner W. L, Sellmann-Richter R, Hehrlein F. W. Prostacyclin in aortocoronary bypass surgery: A double-blind, placebocontrolled study. Thromb. Res. 32: 409-426 1983;
    CrossrefPubMedGoogle Scholar
  • 43 Ditter H, Heinrich D, Matthias F. R, Sellmann-Richter R, Wagner W. L, Hehrlein F. W. Effects of prostaglandin during cardiopulmonary bypass in man on plasma levels of ß-thromboglobulin, platelet factor 4, thromboxane A2, 6-Keto-prostaglandin Fla and heparin. Thromb. Res. 32: 393-408 1983;
    CrossrefPubMedGoogle Scholar