Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1964; 12(02): 355-367DOI: 10.1055/s-0038-1655620 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH A Study of the Coagulant Action of Eight Snake Venoms[*] Authors Author Affiliations Linda Nahas ** 1 Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Oxford, U. K. K. W. E Denson 1 Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Oxford, U. K. R. G Macfarlane 1 Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Oxford, U. K. Recommend Article Abstract Buy Article(opens in new window) Summary An investigation of the eight coagulant snake venoms has revealed the presence in three of these of both a direct thrombin-like activity and the ability to produce a powerful prothrombin activator from factor X in the presence of phospholipid and factor V. The use of antivenom prepared against the venoms indicated that the active principles were antigenically distinct in the genera studied but that some species cross reaction occurred. Full Text References References 1 Biggs R, Douglas A. S, Macfariane R. G. The action of thromboplastic substances. J. Physiol. 122: 554 1963; 2 Biggs R, Macfarlane R. G. Human Blood Coagulation and Its Disorders. 3rd Edition.. Black-well Scientific Publications; Oxford: 1962 3 Denson K. W. Electrophoretic studies of the Prower factor: A blood coagulation factor which differs from factor VII. Brit. J. Haemat. 4: 313 1958; 4 Denson K. W. The specific assay of Prower-Stuart factor and factor VII. Acta Haemat. 25: 105 1961; 5 Esnouf M. P, Williams W. J. The isolation and purification of a bovine-plasma protein which is a substrate for the coagulant fraction of Russell’s viper venom. Biochem. J. 84: 62 1962; 6 Ferguson J. H, Wilson Ennis E. G. Enzymes and blood clotting. II. Antiprothrombin C, Russell’s viper venom (Stypven), and Trypsin. Thrombos. Diathes. haemorrh. (Stuttg.) 9: 62 1963; 7 Fullerton H. W. Estimation of prothrombin. Lancet II: 195 1940; 8 Henrigues O. B, Fishnau M, Henriques S. B. Partial purification and some properties of blood coagulation factor from the venom of Bothrops jararaca. Biochem. J. 75: 551 1960; 9 Hougie C. Effect of Russell’s viper venom (Stypven) on Stuart clotting defect. Proc. Soc. exp. Biol. 93: 570 1956; 10 Macfarlane R. G. The coagulant action of Russell’s viper venom: the use of antivenom in defining its reaction with a serum factor. Brit. J. Haemat. 7: 496 1961; 11 Macfarlane R. G, Barnett B. The haemostatic possibilities of snake venom. Lancet 11: 985 1934; 12 Peden J. C, Peacock A. C. The coagulation of blood by Russell’s viper venom. A reaction between Russell’s viper venom and beef serum factors. J. Lab. clin. Med. 52: 101 1958; 13 Rechnic J, de Vries A, Perlwertter C, Levi C, Kochwa S, Gitter S. Coagulation factors in the venoms of Vipera palestinae and Echis colorata. A preliminary report. Bull. Res. Coun. Israel E 8: 81 1960; 14 Rosenfeld J, Hampe O. G, Kelen E. M. A. Coagulant and fibrinolytic activity of animal venoms; determination of coagulant and fibrinolytic index of different species. Mem. Inst. Butantan 29: 143 1959; 15 Williams W. J, Esnouf M. P. The fractionation of Russell’s viper venom (Vipera Russellii) with special reference to the coagulant protein. Biochem. J. 84: 52 1962;
