Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1965; 13(02): 484-491DOI: 10.1055/s-0038-1656294 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Fibrinolytic and Esterolytic Activity of Human Plasma[*] Authors Author Affiliations D. M Adamis M. D. ** 1 Research Department of Saint Elizabeth’s Hospital and the Tufts University Medical School G. M Maniatis M. D. *** 1 Research Department of Saint Elizabeth’s Hospital and the Tufts University Medical School Recommend Article Abstract Buy Article(opens in new window) Summary The fibrinolytic and esterolytic activity of the plasma before and after activation with Streptokinase is studied. The inhibitors of plasmin are neutralized by the acidification of the plasma or by the acetone treatment. The inhibitors of the “trypsin like enzymes” are neutralized only by acetone. The hydrolysis of the BAEE by the acetone treated and activated plasma seems to be a satisfactory method for the simultaneous determination of the total (plasmin-plasminogen) activity and the total activity of the (trypsin like enzymes) with arginine exopeptidase activity. Full Text References References 1 Milstone H. A Factor in Normal Human Blood which Participates in Streptococcal Fibrinolysis. J. Immun. 42: 100 1941; 2 Blix S. Studies on the Fibrinolytic System in the Euglobulin Fraction of Human Plasma. Scand. J. clin. Invest.. 13, suppl. 58 1961 3 Kaulla K. N. von, Schultz R. L. Methods for the Evaluation of Human Fibrinolysis. Amer. J. clin. Path. 29: 104 1958; 4 Sherry S, Lindemayer R. I, Fletcher A. P, Alkjaersig N. Enhanced Fibrinolytic Activity in Man. J. clin. Invest. 38: 842 1959; 5 Lassen M. The Esterase Activity of the Fibrinolytic System. Biochem. J. 69: 360 1958; 6 Adamis D. M, Maniatis G. M. Effect of Acetone on the Fibrinolytic Mechanism. Fed. Proc. 22:No. 2 1963 7 Astrup T, Mullertz S. The Fibrin Plate Method for Estimating Fibrinolytic Activity. Arch. Biochem. 40: 346 1952; 8 Brown M. E. The Colorimetrie Determination of Arginine Ester Hydrolysis by Human Sera. J. Lab. clin. Med. 55: 616 1960; 9 Kowalski E, Kopec M, Niewiarowski S. An Evaluation of the Euglobulin Method for the Determination of Fibrinolysis. J. clin. Path. 12: 215 1959; 10 Norman P. S. Measurement of Human and Animal Plasminogen. Measurement of an Activator in Human Serum. J. exp. Med. 106: 423 1957; 11 Nardi G. L, Lees C. W. Serum Trypsin: A Diagnostic Test for Pancreatic Disease. New Engl. J. Med. 258: 797 1958; 12 Norman P. S, Hill B. M. Studies of the Plasmin System III. Physical Properties of the two Plasmin Inhibitors in Plasma. J. exp. Med. 108: 639 1958;
