Eigenschaften und Analytik von Heparinoiden

Zusammenfassung

Heparinoide umfassen strukturell und pharmakologisch unterschiedliche Substanzen mit Glykanstruktur. Als wichtigste Vertreter dieser Substanzklasse sind Dermatansulfat, Pentosanpolysulfat, Aprosulat und Orgaran anzusehen. In dieser Übersicht werden die chemische Struktur, die pharmakologischen Wirkungen dieser Stoffe und ihre Analytik besprochen. Sie wirken unterschiedlich auf die Gerinnungskaskade ein und inhibieren Thrombin. Zu ihrem Vergleich sind daher globale Gerinnungsteste notwendig. Ihre genaue pharmakologische Wirkung läßt sich durch spezifische Testsysteme bestimmen. Die chemische Bestimmung ihrer Struktur und Masse erfolgt über Elementaranalyse, spektroskopische, chromatographische und elektrophoretische Methoden.

Schlüsselwörter

Heparinoide - Pharmakologie - Analytik - Dermatansulfat - Pentosanpolysulfat

• LITERATUR

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