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Hamostaseologie 1992; 12(01): 023-036
DOI: 10.1055/s-0038-1660310
Übersichtsarbeit/Review Articles
Schattauer GmbH

Klinische Pharmakologie von Heparinen

J. Harenberg
1   1. Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg (Direktor: Prof. Dr. D. L. Heene)
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Publication History

Publication Date:
26 June 2018 (online)

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Zusammenfassung

Ziel klinisch pharmakologischer Studien von Heparinen sind die Analysen der Bioverfügbarkeit und des Metabolismus. Die Untersuchungen erstrecken sich zum einen auf nicht modifizierte und zum anderen auf modifizierte Heparine und verwandte Substanzen. Neue Nachweisverfahren haben die Bedeutung der Hemmung der Faktor-Xa-Aktivität, des Feed-back loop und der Freisetzung des Extrinsic pathway inhibitor (jetzt: Tissue factor pathway inhibitor) herausgestellt. Untersuchungen zur Neutralisation mit Protaminchlorid legen eine Freisetzung von Mukopolysacchariden durch Heparine im Körper nahe. Chemische Modifikationen von Heparinen und verwandten Substanzen geben eine Aussicht auf bessere Nachweisverfahren, alternative Applikationsformen, spezifischere Wirkungen und neue Anwendungsgebiete.

Schlüsselwörter

Heparin - fraktionierte Heparine - Gerinnung - Fibrinolyse

Key words

Heparin - fractionated heparins - blood coagulation - fibrinolysis
 

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