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Hamostaseologie 1999; 19(04): 182-189
DOI: 10.1055/s-0038-1660417
Übersichtsarbeit/Review Article
Schattauer GmbH

Neue Plasminogen-Aktivatoren: eine klinische Übersicht

A. M. Ross
1   Cardiovascular Research Institute, George Washington University, Washington D. C, USA
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Publication Date:
27 June 2018 (online)

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Zusammenfassung

Der Schlüssel zum Erhalt von Myokardgewebe und einer höheren Überlebensrate bei akutem Herzinfarkt ist eine rasche Wiederherstellung der Durchgängigkeit der Infarktarterie. Das Verständnis dieses Zusammenhangs war Ausgangspunkt für die Anwendung der Gentechnik zur Entwicklung neuer Plasminogen-Aktivatoren mit speziellen klinischen Eigenschaften. Diese neuartigen Aktivatoren sollten zu einer rascheren und auch vollständigeren Perfusion führen und gleichzeitig ein geringeres Risiko für Blutungen und intrazerebrale Blutungen aufweisen. In diesem Übersichtsbeitrag werden die pharmakologischen Profile und die klinischen Eigenschaften verschiedener neuer Plasminogen-Aktivatoren, die gentechnisch hergestellt werden und von humanem Gewebe-Plasminogen-Aktivator bzw. aus tierischen oder bakteriellen Proteinen abgeleitet sind, dargelegt.

Schlüsselwörter

Thrombolyse - Plasminogen-Aktivatoren - akuter Herzinfarkt - TNK-tPA
 

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