Recent Advancement of Clinical Information Systems: Opportunities and Challenges

Summary

Objectives: Clinical information systems (CISs) have generated opportunities for meaningful improvements both in patient care and workflow but there is still a long way to perfection. Healthcare providers are still facing challenges of data exchange, management, and integration due to lack of functionality among these systems. Our objective here is to systematically review, synthesize, and summarize the literature that describes the current stage of clinical information systems, so as to assess the current state of knowledge, and identify benefits and challenges.

Methods: PubMed, EMBASE, and the bibliographies of articles were searched for studies published until September 1, 2017, which reported on significant advancement of clinical information systems, as well as problems and opportunities in this field. Studies providing the most detailed information were included and the others were kept only as references.

Results: We selected 23 papers out of 1,026 unique abstracts for full-text review using our selection criteria, and 20 out of these 23 studies met all of our inclusion criteria. We focused on three major areas: 1) Ambulatory and inpatients clinical information systems; 2) Specialty information systems; and 3) Ancillary information systems. As CIS can support evidence-based practices that, in turn, improve patient's safety, quality and efficacy of care, advancement, acceptability, and adaptability of CIS have increased worldwide. Although, the demand for CIS functionality is rising fast, current CISs still have data integration challenges and lack of functionality to exchange patient information from all or some parts of the healthcare system. These limitations can be attributed to technical, human, and organizational factors

Conclusion: Clinical information systems provide tremendous opportunities to reduce clinical errors such as medication errors and diagnostic errors and to support healthcare professionals by offering up-to-date patient information. They promise to improve workflow and efficiency of care, thus boosting the overall quality of healthcare.

Keywords

Clinical Information System - Electronic Medical Record - Hospital Information System - Computerized Provider Order Entry

1 Introduction

Healthcare industry is underperforming despite having a record in spending, and major concerns have been raised due to a wide range of clinical errors[1]. The cost of these errors is mounting expenses from compensatory therapies, readmissions, and unnecessary tests. According to a study[2], clinical errors in the United States (US) cost about 19.5 billion dollars in 2008, of which 17 billion dollars were directly associated with added medical costs such as ancillary services, prescription drug services, and inpatient and outpatient care. In the US, more than 250,000 deaths per year have been attributed to medical errors which has become the third leading cause of death after heart disease and cancer[3].

Clinical information systems (CISs) are crucial to delivering the best in evidence-based, and patient-centered care[4]. It has great potential in reducing medical errors, increasing legibility, cutting unnecessary healthcare costs, and boosting the quality of healthcare. The major role of CISs is to capture, store, process, and timely transfer information to clinical decision makers for a correct and rapid decision[5] [6]. For example, a CIS can easily import data from different instruments such as vital signs monitors, ventilators, and infusion devices, store them safely, and display them in specific tables and formats. One advantage of this type of systems is to interconnect with other subsystems in the hospital, e.g. pharmacy, different laboratories, radiology, and different image processing storage solutions[7]. A good CIS contributes positively to patient's safety, workflow efficiency, and to point-of-care decision support[8] [9]. The development of CISs has posed some new challenges and, at the same time, has also generated new opportunities[10] [11].

As the healthcare industry is suffering from being a heterogeneous system made of disparate silos of data, with lack of standardization, healthcare providers are seeking a way to modernize their existing systems with novel CISs that allow storing, managing, and exchanging health information within and among hospitals. The efforts to implement better CISs have been intensified. Therefore, we conducted a review of published literature to provide information regarding the current state of CIS.

2 Methods

Data Sources and Searches

We performed a systematic review of the literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines[12]. The relevant literature databases such as PubMed, EMBASE, Google, Google Scholar, and Scopus were searched for articles published until September 1, 2017, which report on the advancement of clinical information systems. We used the following words as search terms: “clinical information systems”, “CIS”, “Computerized provider order entry”, “ CPOE”, “Inpatient electronic medical records”, “Outpatient electronic medical record”, “Emergency department information system”, “ICU information system”, “Cardiology information system”, “Oncology information system”, “Laboratory information system”, “LIS”, “Pharmacy information system”, “PIS”, “Radiology information system”, “RIS”, “Advancement of CIS”, “Opportunity of CIS”, and “Challenges of CIS”. [Table 1] provides an overview of our specific search strategies. The reference lists of all included full-text articles were searched to identify any studies missed in the initial search, and Google Scholar was used to find academic works citing eligible articles. Unpublished studies and references that only provided an abstract were not considered. References were compiled and managed using EndnoteX7 (Thomson Reuters), with duplicates removed using this software.

Table 1 Summary of the study selection process

Areas	Selected Keywords	Databases	Number of Identified articles
Ambulatory and Inpatient Clinical Information Systems	“Ambulatory electronic medical record”, “OPD electronic medical records”, “ Inpatient clinical information system”, “Inpatients electronic medical record”, “ computerized provider order entry”	PubMed, EMBASE, Google, Google scholar, Scopus	548
Specialty systems	“ICU information system”, “Cardiology information system”, “Oncology information system”	PubMed, EMBASE, Google, Google scholar, Scopus	326
Ancillary Information Systems	“Laboratory information system”, “Pharmacy information system”, “Radiology information system”	PubMed, EMBASE, Google, Google scholar, Scopus	152

Inclusion and Exclusion Criteria

Two authors (MMI, TNP) who are experts in CIS independently scrutinized all titles and abstracts, and obtained full-texts of potentially relevant articles. In the initial stage, our selection criteria allowed the inclusion of any relevant study. Then, authors examined the retrieved articles independently, removed duplicates, and determined whether the study should be included or excluded. Studies had to meet the following inclusion criteria:

• Be published in English;

• Provide all information regarding to ambulatory and inpatient clinical information systems (electronic medical record and computerized provider order entry);

• Provide all information about specialty systems (intensive care unit information system, cardiology information system, oncology information system);

• Provide all information about ancillary information system (radiology information system, laboratory information system, and pharmacy information system);

• Provide information about challenges and opportunities.

Studies were excluded if they met the following criteria:

• Be editorials, short communications, or case studies;

• Not published in English;

• No discussion on opportunities and challenges of clinical information systems.

Data Extraction

The same two authors (MMI, TNP) ensured the appropriateness of including studies in the final analysis. All discrepancies were resolved by consensus and discussed with the main investigator. In this stage, detailed information was extracted regarding:

• Current advancement of CISs;

• Classification of CISs;

• Opportunities of CISs;

• Challenges for implementing CISs;

• Infrastructure and information flows of CISs.

Outcome Parameters

The two outcome parameters of this survey report were: (1) to describe the status of clinical information systems; and (2) to identify the challenges and opportunities of clinical information systems.

3 Results

Article Selection

A total of 1,026 original articles were identified. Of these, 1,003 articles were excluded based on predetermined eligibility criteria described above, while the remaining 23 articles underwent detailed full-text evaluation. Among these, 20 met all of our inclusion criteria. [Figure 1] summarizes the selection process.

Fig. 1 Flowchart of the literature search (adapted from the PRISMA group 2009 flow diagram).

Infrastructure and Information Flows of Clinical Information Systems

CISs are computer systems that provide immediate access to current patient data regarding clinical notes, medication history, laboratory reports, images, and reports either directly or via data networks. They are parts of a hospital information system, which facilitates direct patient care. An effective CIS warrants cost reduction, workflow improvement, and standardization of procedures. A CIS consists of a wide range of networking technology, clinical databases, electronic medical records, as well as other clinical informatics research evidence systems. [Figure 2] provides a generic model of information flows among CISs. Information from various CISs is entered into an electronic health record. This information is then networked to different databases as needed. Clinical information from EHRs and different other systems is then exchanged for proper and effective treatment, e.g., it may be used for effective decision-making. The United States Health Insurance Portability and Accountability Act (HIPAA) covers privacy and security provisions for safeguarding clinical information. All systems use the Health Level Seven (HL7) standard for proper exchange of a patient's information. A CIS is widely seen as a significant clinical component of hospital information system solutions. CISs have been changing rapidly and offering unique opportunities as well as challenges never experienced before. Both opportunities and challenges cut though technological, organizational, and human factors. However, the interaction between these factors is responsible for providing a more informative and rich lens for understanding the current and future landscape of CIS[13].

Fig. 2 Infrastructure and flows in clinical information systems.

This paper focuses on three major areas of clinical information systems, namely, (1) ambulatory and inpatient clinical information systems; (2) specialty information systems; and (3) ancillary information systems.

3.1 Ambulatory and Inpatient Clinical Information Systems

Electronic Medical Record

An electronic medical record (EMR) is the infrastructure that spans across almost all CIS subsystems. EMRs are key components for ambulatory and inpatient clinical information systems[14]. In the U.S., the adoption rate of basic EMR systems among all providers has been increased from 9.4% in 2008 to 67% in 2017. Physician specialists with the highest adoption rates were 76% in internal medicine and pediatrics, followed by nephrology (75%), family practice (75%), and urology (74%)[15]. Nowadays, patients’ family history is being included into EMRs. This is useful to access potential disease risks and offer insight into the interplay between inherited and social factors relevant to patient care[16]. As some specific gene variants among person to person cause a specific disorder and are responsible for changing the effects of medications, the whole exome or genome sequencing data is being stored into EMRs[17]. Integration of biobanks with e-health records makes each resource more valuable and accelerates the translational pipeline, although helping to accurately identify subjects with specific diseases and phenotypes as well as identifying genotype-phenotype associations[18]. Evans et al.[19] mentioned that sophisticated care depends on various medical devices in order to monitor a patient's vital signs and additional information that is not specifically valuable for EMRs but is essential for clinical decision support applications to prevent adverse outcomes.

Computerized Provider Order Entry

Computerized provider order entry systems (CPOEs) are essential components of ambulatory and inpatient clinical information systems. They allow a physician to prescribe electronically, communicate with various departments (e.g. pharmacy, laboratory, radiology, intensive care unit) and alert physicians on potential drug-drug or drug-allergy interactions. Nuckols et al.[20] reported that CPOEs were associated with half as many preventable adverse effects (pooled risk ratio (RR) = 0.47, CI_95%=[0.31, 0.71]) and medication errors (RR = 0.46, CI_95%=[0.35, 0.60]). They also mentioned implementing CPOEs with clinical decision support systems (CDSSs) could yield substantial long-term savings to society in the United States. However, the implementation and use of CPOEs with CDSSs is complex and fragile. A careful planning, implementation, and maintenance are required to get proper functionality otherwise this may create a potential safety risk. Nowadays, when leveraging a new technology, healthcare organizations are developing and using a risk assessment process to identify and evaluate unanticipated consequences and CPOE-generated errors. Elsaid et al.[21] mentioned that electronic chemotherapy prescribing reduced prescribing errors, reduced significant toxicities at clinically prescribed doses, but rose serious issues of drug safety. Also, Forrester et al.[22] demonstrated that over the five years’ period, CPOEs cost $18 million less than paper prescribing, and were associated with less than 1.5 million medication errors and 14,500 adverse drug effects[23].

3.2 Specialty Information Systems

Intensive Care Unit Information Systems

Intensive care unit information systems (ICUISs) reduce physicians time spending on documentation and increase the time available for direct patient care by providing protocol templates and flow sheets[24]. They support the continuous assessment and adjustment of medication, the automatic capture of physiologic parameters from patient monitors, the display of patients’ vital conditions, and the categorization of patients based on SOFA and APACHE score for proper decision-making. Ehteshami et al.[25] mentioned that ICUISs can improve practitioner satisfaction, quality of care, and cost-effectiveness. However, ICUISs should be integrated with health information systems (HISs), such as EMRs and patient monitoring systems, to maximize the benefits from ICUISs. Levesque et al.[26] reported that with the use of ICUISs, the time per admission and coding errors were reduced, from 6.8 ± 2.8 min in 2007 to 3.6 ± 1.9 min in 2008, p < 0.001, and from 7.9% to. 2.2%, p < 0.001, respectively. Bosman et al.[27] reported a 30% reduction in documentation time (paper 20.5% of total nursing time vs. ICUIS 14.4%, p<0.001). Levesque et al.[28] showed that the implementation of ICUISs allowed shortening ICU length of stay without altering other patient outcomes (8.4 ± 15.2 vs. 6.8 ± 12.9 days, p = 0.048). However, the use of an ICUIS changes medical and nursing activities, as well as influences cross-disciplinary communication during ICU ward rounds[29].

Cardiology Information Systems

Cardiovascular diseases have increased along with the demand for productive data management tools in the cardiac care departments. A cardiovascular information system (CVIS) plays a vital role in monitoring, management, evaluation, and policy development related to cardiac diseases[30]. A CVIS integrates all cardiology requests, procedures, images, and reports. When CVISs are integrated with other clinical information systems, physicians can extract images and reports from any computer inside and outside of the hospital through a portal. A CVIS can offer structured templates for echo, pediatrics, peripheral vascular, cath lab, and other systems. In addition, the demand for CISs has been increased with cardiovascular picture archiving and communication systems (CPACS) that provide effective data analysis and accurate therapeutic decisions in less time[31]. Additionally, hospital information systems are integrated with CVISs for exchanging 4D echocardiography, nuclear medicine, computed tomography (CT) angiography, and pediatric echocardiography reports. It is becoming evident that technological complexity, management of a large amount of data, data retrieval, and lack of skilled human resources in cardiology are creating the need for better CVISs[32].

Oncology Information Systems

The use of oncology information systems (OISs) has been increasing due to the complexity of new drugs and new radiation therapies, government regulations, and legal liability issues[33]. To ensure effective and efficient oncology treatment, OISs are crucial for measuring the rate of adoption and the effectiveness of practice standards as well as facilitate clinical practice and research[34]. These systems combine radiation, medical and surgical oncology information into a complete, oncology specific EMR, which help physicians to manage their patients’ entire information from diagnosis through follow-up. Nielsen et al. mentioned five key parameters for usability of OISs:

1. Learnability (systems functionality is easy to learn);

2. Efficiency (functionality raises over the time which means the more advance a user is and that a higher productivity is achieved);

3. Memorability;

4. Minimized errors;

5. Increase satisfaction.

However, the success of OISs depends on several key factors including the need for change, physicians’ leadership and engagement in the change process, workflow optimization, provision of the education and resources needed to implement[35] [36]. Additionally, proficient knowledge and understanding of databases, and the collectivity of different subsystems should bring effective results. However, the free choice of implementation standards could lead to interoperability problems[37].

3.3 Ancillary Information Systems

Radiology Information Systems

Being able to easily integrate images into a report via the radiology information system (RIS) should improve healthcare providers’ workflows as well as promote healthcare service quality, increase stakeholder satisfaction, improve total treatment quality, and gain competitive advantages[38]. Unification of RISs allows radiologists to easily get appropriate information for diagnosis in a unified workflow. The primary advantage of these systems lies in their ability to keep huge amounts of data readily accessible to ensure rapid workflow management and facilitate rapid communication. However, these systems only ensure high security, reliability, and privacy because they are only accessible by authorized physicians and technicians[39]. Additionally, picture archiving and communication systems (PACS) are central for clinical imaging and they process data from various medical devices such as computed radiography, CT scan, magnetic resonance imaging (MRI), and ultrasonography[40] [41]. Successful integration and interoperability among RISs and other systems such as EHRs, PACSs and LISs can create a flexible environment of data exchange/sharing, and provide more specific treatment options[42].

Laboratory Information Systems

Laboratory information systems (LIS) are computerized systems for rich sources of data that could be used for numerous purposes including operations, quality projects, and research[43]. They foster accuracy and accessibility to the flow of samples and data in clinical laboratories. Physicians may easily track each step in the testing process, from the administration of tests to the receipt of test results which supports timely decision-making and diagnosis[44]. It is important to enable bi-directional interfaces between LISs and other information systems such as EHRs to ensure a seamless flow of information ranging from test ordering to results storing for clinical decision support[45] [46]. The integration of LISs with other systems is always challenging because of large hospital networks, technological complexity, interface design, and the multitude of clinical and laboratory workflows. The major challenges observed when implementing an interface between LISs and EHRs are the selection and harmonization of test codes, the communication with EHR providers, fluid orders and collection, problems with displaying laboratory results, the risk of missing abnormal flags, ordering specimens for anatomic pathology, and unanticipated changes to laboratory workflows[14] [47].

Pharmacy Information Systems

In recent years, the advancement of pharmacy information systems (PISs) has been gaining attention due to the reduction of clinical errors with intelligent warnings, messages, and rejection notices about medications. Also, PISs have been playing a vital role in preventing dosage errors by providing an individual dosage limit according to patient's age, gender, and other factors. Most importantly, PISs help to monitor drug-drug interactions, drug allergies, and various drug-related complications. Mahalli et al.[48] reported that the integration of a CPOE and a PIS has nearly eliminated the need for pharmacy staff to reenter medication orders from the CPOE system. The market size of PISs has been increasing due to their significant benefits and it is expected to grow at 7.7% from 2014 to 2019. However, economic, cultural, and political challenges need to be addressed before all the benefits can be realized.

4 Discussion

Our study shows that clinical information systems clearly offer significant improvements to patient care. They are important tools in primary care for recording and managing patients’ information in an efficient manner. They also support the organization of patients’ demographic and clinical data; data storage and manipulation ensure overall care of the patients. In addition, managing clinical information through CISs helps to reduce prescription errors, unnecessary testing, and hospitalizations. CISs can support the meaningful and effective treatment of patients, and could improve safety, productivity, and healthcare outcomes.

4.1 Major Opportunities

The healthcare delivery system is changing in many ways. Technological advances are providing opportunities to optimize patient care. CISs have the potential to address many problems encountered in healthcare, namely, managing large amounts of patient and research data, reduce healthcare costs/ errors, increase legibility, and boost the quality of healthcare[13]. A physician can remotely, directly and timely, access (updates of) a patient's medical history supported by e.g. automatic sorting or summarization of clinical data[49]. By examining a patient's medical history in the context of relevant clinical research, physicians can take informed and evidence-based decisions. Optimal integration with other relevant systems in the HIS ensures that a CIS enhances communication among physicians, radiologists, pathologists, nurses, and other healthcare staff. This could lead to better clinical workflows, decision-making, reduction in adverse events, and ultimately, the improvement of the overall quality of care and patient safety[50] [51]. For example, bi/multi-directional interfaces among CISs (LIS-EHR, RIS-EHR, PIS-her, etc.) enable a seamless flow of information from test/exam ordering to results presentation, and therefore facilitate faster test turnaround times resulting in quicker diagnosis for patients. CISs may also reduce test and medication errors through dose adjustment, dose range checking, therapeutic duplication checks, formulary alerts, drug-allergy, drug-drug and drug-laboratory interaction checks, and unnecessary test reminders[52]. [Table 2] shows major opportunities for clinical information systems.

Table 2 Major opportunities for clinical information systems.

▪ Direct access to instant updates of a patient's medical record as well as remote access to patients’ records.	▪ Improve quality and optimize the use of resources throughout the health system.
▪ Healthcare professionals access to all information and services they need in one place.	▪ Development of efficient and intuitive data processing software and bioinformatics tools.
▪ Patients-centric decision-making based on best clinical evidence.	▪ Pleasurable and respectful interaction with users.
▪ Improve data quality and the analysis of a patient's data by combining it with the physician's own knowledge.	▪ Enhance communication among physicians, radiologists, pathologists, nurses, and other healthcare staff.
▪ Development of better and more effective security protocols.	▪ Incorporation of IT professionals to the ICU.
▪ Faster test turnaround times to provide quicker diagnosis for patients.	▪ Greater chance to conduct potential research based on reality.
▪ Utilization of a standard format to communicate with different clinical information systems.	▪ Defense of value over volume.

4.2 Major Challenges

CISs clearly offer excellent opportunities for improving care quality. Nevertheless, implementing CISs in healthcare organizations poses a series of challenges[53]. The adoption of IT in healthcare has been particularly slow and lagging behind as compared to other domains. This is due to the complexity in issues like interoperability, technological rationality, acceptability, managerial rationality, data security, data quality, and standards. A CIS typically provides a wide range of data repositories, medical reports, clinical decision support systems etc. that are generally not accessible in an integrated fashion. Further, current CISs implementations tend to have a lack of functionality to provide easy access and to create reminders[54]. In general, one can observe poor or even absent support for the exchange of patient-related information within the healthcare system, preventing immediate access to up-to-date and complete patient information.

Major challenges of clinical information systems are given in [Table 3].

Table 3 Major challenges of clinical information systems.

▪ Development and integration among subsystems.	▪ Interoperability.
▪ Direct and indirect costs because of high initial investments and low perceived return on investment.	▪ Legacy systems that make clinical information systems’ workflows complex.
▪ Interaction between administrative staff and physicians.	▪ Technical implication and data quality.
▪ Competent project management team.	▪ Security and privacy.
▪ Integration of precision medicine into the workflow.	▪ Integration across disciplines and sufficient educational resources.
▪ Different data models among different vendors and sites.	▪ Communication among a large number of clinicians from multiple specialties.
▪ Limited user capability to provide separate information for quality measurement.	▪ Medical rationality.
▪ Inappropriateness of some default information.	▪ Software maturity.

5 Conclusion

Summarizing, there is an enormous potential for CISs to significantly improve clinical processes and even affect healthcare outcomes. The key benefits of CISs include reducing medical errors, improving clinical decision-making during patient encounters, and providing universal access to a patient's information in real time. However, to harvest the sweet benefits of CISs, one must address the major challenges and pitfalls during the planning, design, and implementation of such systems. Additionally, healthcare organizations should adopt CISs to improve quality of care and to be able to stay competitive. The ultimate goal is to strike a balance between available resources, current HIS architecture, and the desired clinical improvement objectives. The quest to a perfect CIS is a long journey that is best started today.

Conflict of interest:

None

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