Semin Musculoskelet Radiol 2018; 22(05): 564-581
DOI: 10.1055/s-0038-1673623
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Musculoskeletal Imaging: Current Practice and Future Directions

Terence Patrick Farrell
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
2   Diagnostic Imaging Department, Cappagh National Orthopaedic Hospital, Dublin, Ireland
,
Niamh Catherine Adams
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
,
John P. Walsh
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
,
John Hynes
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
,
Sarah Kate Eustace
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
,
Eoin Kavanagh
1   Diagnostic Imaging Department, Mater Misericordiae University Hospital, Dublin, Ireland
2   Diagnostic Imaging Department, Cappagh National Orthopaedic Hospital, Dublin, Ireland
› Author Affiliations
Further Information

Publication History

Publication Date:
06 November 2018 (online)

Abstract

Musculoskeletal (MSK) radiology plays a crucial role in the diagnosis and management of MSK disorders and has rapidly expanded in tandem with advances in technology and improved access to imaging. Although anatomical imaging remains the mainstay of MSK radiology, significant progress has been made in functional and molecular imaging as well as in hybrid imaging with an expanding armament of technologies becoming available or in development. A vast array of research is occurring in MSK imaging, and this review article highlights some of the most promising current and future clinical applications in development in each of the major imaging modalities. Identifying the clinical utility of these technologies in an era of rising health care costs is an important challenge for MSK radiologists.

 
  • References

  • 1 Vos T, Abajobir AA, Abate KH. , et al; GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390 (10100): 1211-1259
  • 2 Gyftopoulos S, Harkey P, Hemingway J, Hughes DR, Rosenkrantz AB, Duszak Jr R. Changing musculoskeletal extremity imaging utilization from 1994 through 2013: a Medicare beneficiary perspective. AJR Am J Roentgenol 2017; 209 (05) 1103-1109
  • 3 Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med 1999; 42 (05) 952-962
  • 4 Griswold MA, Jakob PM, Heidemann RM. , et al. Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 2002; 47 (06) 1202-1210
  • 5 Barth M, Breuer F, Koopmans PJ, Norris DG, Poser BA. Simultaneous multislice (SMS) imaging techniques. Magn Reson Med 2016; 75 (01) 63-81
  • 6 Fritz J, Fritz B, Zhang J. , et al. Simultaneous multislice accelerated turbo spin echo magnetic resonance imaging: comparison and combination with in-plane parallel imaging acceleration for high-resolution magnetic resonance imaging of the knee. Invest Radiol 2017; 52 (09) 529-537
  • 7 Jaspan ON, Fleysher R, Lipton ML. Compressed sensing MRI: a review of the clinical literature. Br J Radiol 2015; 88 (1056): 20150487
  • 8 Hammernik K, Klatzer T, Kobler E. , et al. Learning a variational network for reconstruction of accelerated MRI data. Magn Reson Med 2018; 79 (06) 3055-3071
  • 9 Lim D, Han Lee Y, Kim S, Song HT, Suh JS. Clinical value of fat-suppressed 3D volume isotropic spin-echo (VISTA) sequence compared to 2D sequence in evaluating internal structures of the knee. Acta Radiol 2016; 57 (01) 66-73
  • 10 Jung JY, Yoon YC, Kim HR, Choe BK, Wang JH, Jung JY. Knee derangements: comparison of isotropic 3D fast spin-echo, isotropic 3D balanced fast field-echo, and conventional 2D fast spin-echo MR imaging. Radiology 2013; 268 (03) 802-813
  • 11 Subhas N, Kao A, Freire M, Polster JM, Obuchowski NA, Winalski CS. MRI of the knee ligaments and menisci: comparison of isotropic-resolution 3D and conventional 2D fast spin-echo sequences at 3 T. AJR Am J Roentgenol 2011; 197 (02) 442-450
  • 12 Fritz J, Raithel E, Thawait GK, Gilson W, Papp DF. Six-fold acceleration of high-spatial resolution 3D SPACE MRI of the knee through incoherent k-space undersampling and iterative reconstruction—first experience. Invest Radiol 2016; 51 (06) 400-409
  • 13 Welsch GH, Mamisch TC, Hughes T. , et al. In vivo biochemical 7.0 Tesla magnetic resonance: preliminary results of dGEMRIC, zonal T2, and T2* mapping of articular cartilage. Invest Radiol 2008; 43 (09) 619-626
  • 14 Joseph GB, Baum T, Alizai H. , et al. Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years—data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2012; 20 (07) 727-735
  • 15 Domayer SE, Apprich S, Stelzeneder D. , et al. Cartilage repair of the ankle: first results of T2 mapping at 7.0 T after microfracture and matrix associated autologous cartilage transplantation. Osteoarthritis Cartilage 2012; 20 (08) 829-836
  • 16 Singh A, Haris M, Cai K, Kogan F, Hariharan H, Reddy R. High resolution T1ρ mapping of in vivo human knee cartilage at 7T. PLoS One 2014; 9 (05) e97486
  • 17 Staroswiecki E, Bangerter NK, Gurney PT, Grafendorfer T, Gold GE, Hargreaves BA. In vivo sodium imaging of human patellar cartilage with a 3D cones sequence at 3 T and 7 T. J Magn Reson Imaging 2010; 32 (02) 446-451
  • 18 Trattnig S, Welsch GH, Juras V. , et al. 23Na MR imaging at 7 T after knee matrix-associated autologous chondrocyte transplantation preliminary results. Radiology 2010; 257 (01) 175-184
  • 19 Zbýň S, Stelzeneder D, Welsch GH. , et al. Evaluation of native hyaline cartilage and repair tissue after two cartilage repair surgery techniques with 23Na MR imaging at 7 T: initial experience. Osteoarthritis Cartilage 2012; 20 (08) 837-845
  • 20 Chang G, Honig S, Liu Y. , et al. 7 Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density. J Bone Miner Metab 2015; 33 (03) 285-293
  • 21 Gondim Teixeira PA, Ledrich M, Kauffmann F. , et al. Qualitative 3-T proton MR spectroscopy for the characterization of musculoskeletal neoplasms: update on diagnostic performance and indications. AJR Am J Roentgenol 2017; 208 (06) 1312-1319
  • 22 Patni RS, Boruah DK, Sanyal S. , et al. Characterisation of musculoskeletal tumours by multivoxel proton MR spectroscopy. Skeletal Radiol 2017; 46 (04) 483-495
  • 23 Hsieh TJ, Li CW, Chuang HY, Liu GC, Wang CK. Longitudinally monitoring chemotherapy effect of malignant musculoskeletal tumors with in vivo proton magnetic resonance spectroscopy: an initial experience. J Comput Assist Tomogr 2008; 32 (06) 987-994
  • 24 Del Grande F, Ahlawat S, Subhangwong T, Fayad LM. Characterization of indeterminate soft tissue masses referred for biopsy: what is the added value of contrast imaging at 3.0 Tesla?. J Magn Reson Imaging 2017; 45 (02) 390-400
  • 25 Dudeck O, Zeile M, Pink D. , et al. Diffusion-weighted magnetic resonance imaging allows monitoring of anticancer treatment effects in patients with soft-tissue sarcomas. J Magn Reson Imaging 2008; 27 (05) 1109-1113
  • 26 Horger M, Weisel K, Horger W, Mroue A, Fenchel M, Lichy M. Whole-body diffusion-weighted MRI with apparent diffusion coefficient mapping for early response monitoring in multiple myeloma: preliminary results. AJR Am J Roentgenol 2011; 196 (06) W790–795
  • 27 Lim HK, Jee WH, Jung JY. , et al. Intravoxel incoherent motion diffusion-weighted MR imaging for differentiation of benign and malignant musculoskeletal tumours at 3 T. Br J Radiol 2018; 91 (1082): 20170636
  • 28 Kumar Y, Khaleel M, Boothe E, Awdeh H, Wadhwa V, Chhabra A. Role of diffusion weighted imaging in musculoskeletal infections: current perspectives. Eur Radiol 2017; 27 (01) 414-423
  • 29 Eguchi Y, Ohtori S, Yamashita M. , et al. Diffusion magnetic resonance imaging to differentiate degenerative from infectious endplate abnormalities in the lumbar spine. Spine 2011; 36 (03) E198-E202
  • 30 Gondim Teixeira PA, Renaud A, Aubert S. , et al. Perfusion MR imaging at 3-Tesla: can it predict tumor grade and histologic necrosis rate of musculoskeletal sarcoma?. Diagn Interv Imaging 2018; (March): S2211-5684(18)30063-9
  • 31 Del Grande F, Subhawong T, Weber K, Aro M, Mugera C, Fayad LM. Detection of soft-tissue sarcoma recurrence: added value of functional MR imaging techniques at 3.0 T. Radiology 2014; 271 (02) 499-511
  • 32 Kaushik A, Sankaran B, Varghese M. Prognostic value of dynamic MRI in assessing post-traumatic femoral head vascularity. Skeletal Radiol 2009; 38 (06) 565-569
  • 33 Geith T, Niethammer T, Milz S, Dietrich O, Reiser M, Baur-Melnyk A. Transient bone marrow edema syndrome versus osteonecrosis: perfusion patterns at dynamic contrast-enhanced MR imaging with high temporal resolution can allow differentiation. Radiology 2017; 283 (02) 478-485
  • 34 Madhuranthakam A, Lenkinski R. Technical advancements in MR neurography. Semin Musculoskelet Radiol 2015; 19 (02) 86-93
  • 35 Bulut HT, Yildirim A, Ekmekci B, Gunbey HP. The diagnostic and grading value of diffusion tensor imaging in patients with carpal tunnel syndrome. Acad Radiol 2014; 21 (06) 767-773
  • 36 Chen YY, Lin XF, Zhang F. , et al. Diffusion tensor imaging of symptomatic nerve roots in patients with cervical disc herniation. Acad Radiol 2014; 21 (03) 338-344
  • 37 Oikawa Y, Eguchi Y, Inoue G. , et al. Diffusion tensor imaging of lumbar spinal nerve in subjects with degenerative lumbar disorders. Magn Reson Imaging 2015; 33 (08) 956-961
  • 38 Yamasaki T, Fujiwara H, Oda R. , et al. In vivo evaluation of rabbit sciatic nerve regeneration with diffusion tensor imaging (DTI): correlations with histology and behavior. Magn Reson Imaging 2015; 33 (01) 95-101
  • 39 Morisaki S, Kawai Y, Umeda M. , et al. In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging. J Magn Reson Imaging 2011; 33 (03) 535-542
  • 40 Li GD, Liang YY, Xu P, Ling J, Chen YM. Diffusion-tensor imaging of thigh muscles in Duchenne muscular dystrophy: correlation of apparent diffusion coefficient and fractional anisotropy values with fatty infiltration. AJR Am J Roentgenol 2016; 206 (04) 867-870
  • 41 Yanagisawa O, Kurihara T, Kobayashi N, Fukubayashi T. Strenuous resistance exercise effects on magnetic resonance diffusion parameters and muscle-tendon function in human skeletal muscle. J Magn Reson Imaging 2011; 34 (04) 887-894
  • 42 Raya JG, Melkus G, Adam-Neumair S. , et al. Diffusion-tensor imaging of human articular cartilage specimens with early signs of cartilage damage. Radiology 2013; 266 (03) 831-841
  • 43 Dutoit JC, Verstraete KL. Whole-body MRI, dynamic contrast-enhanced MRI, and diffusion-weighted imaging for the staging of multiple myeloma. Skeletal Radiol 2017; 46 (06) 733-750
  • 44 Lecouvet FE, El Mouedden J, Collette L. , et al. Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer?. Eur Urol 2012; 62 (01) 68-75
  • 45 Takenaka D, Ohno Y, Matsumoto K. , et al. Detection of bone metastases in non-small cell lung cancer patients: comparison of whole-body diffusion-weighted imaging (DWI), whole-body MR imaging without and with DWI, whole-body FDG-PET/CT, and bone scintigraphy. J Magn Reson Imaging 2009; 30 (02) 298-308
  • 46 Albano D, Patti C, La Grutta L. , et al. Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. Eur J Radiol 2016; 85 (02) 313-318
  • 47 Siegel MJ, Acharyya S, Hoffer FA. , et al. Whole-body MR imaging for staging of malignant tumors in pediatric patients: results of the American College of Radiology Imaging Network 6660 Trial. Radiology 2013; 266 (02) 599-609
  • 48 Day J, Patel S, Limaye V. The role of magnetic resonance imaging techniques in evaluation and management of the idiopathic inflammatory myopathies. Semin Arthritis Rheum 2017; 46 (05) 642-649
  • 49 Krabbe S, Østergaard M, Eshed I. , et al. Whole-body magnetic resonance imaging in axial spondyloarthritis: reduction of sacroiliac, spinal, and entheseal inflammation in a placebo-controlled trial of adalimumab. J Rheumatol 2018; 45 (05) 621-629
  • 50 Weckbach S, Schewe S, Michaely HJ, Steffinger D, Reiser MF, Glaser C. Whole-body MR imaging in psoriatic arthritis: additional value for therapeutic decision making. Eur J Radiol 2011; 77 (01) 149-155
  • 51 Schanz S, Henes J, Ulmer A. , et al. Response evaluation of musculoskeletal involvement in patients with deep morphea treated with methotrexate and prednisolone: a combined MRI and clinical approach. AJR Am J Roentgenol 2013; 200 (04) W376–382
  • 52 Koff MF, Burge AJ, Koch KM, Potter HG. Imaging near orthopedic hardware. J Magn Reson Imaging 2017; 46 (01) 24-39
  • 53 Hargreaves BA, Worters PW, Pauly KB, Pauly JM, Koch KM, Gold GE. Metal-induced artifacts in MRI. AJR Am J Roentgenol 2011; 197 (03) 547-555
  • 54 Delfaut EM, Beltran J, Johnson G, Rousseau J, Marchandise X, Cotten A. Fat suppression in MR imaging: techniques and pitfalls. Radiographics 1999; 19 (02) 373-382
  • 55 Robson MD, Gatehouse PD, Bydder M, Bydder GM. Magnetic resonance: an introduction to ultrashort TE (UTE) imaging. J Comput Assist Tomogr 2003; 27 (06) 825-846
  • 56 Koch KM, Lorbiecki JE, Hinks RS, King KF. A multispectral three-dimensional acquisition technique for imaging near metal implants. Magn Reson Med 2009; 61 (02) 381-390
  • 57 Lu W, Pauly KB, Gold GE, Pauly JM, Hargreaves BA. SEMAC: slice encoding for metal artifact correction in MRI. Magn Reson Med 2009; 62 (01) 66-76
  • 58 Hargreaves BTV, Yoon D. Fast 2D imaging for distortion correction near metal implants [abstract 615]. Paper presented at: 22th Annual Meeting of the International Society for Magnetic Resonance in Medicine; 2014 ; Milan, Italy
  • 59 Choi SJ, Koch KM, Hargreaves BA, Stevens KJ, Gold GE. Metal artifact reduction with MAVRIC SL at 3-T MRI in patients with hip arthroplasty. AJR Am J Roentgenol 2015; 204 (01) 140-147
  • 60 Ai T, Padua A, Goerner F. , et al. SEMAC-VAT and MSVAT-SPACE sequence strategies for metal artifact reduction in 1.5T magnetic resonance imaging. Invest Radiol 2012; 47 (05) 267-276
  • 61 Carl M, Koch K, Du J. MR imaging near metal with undersampled 3D radial UTE-MAVRIC sequences. Magn Reson Med 2013; 69 (01) 27-36
  • 62 Gervaise A, Osemont B, Lecocq S. , et al. CT image quality improvement using adaptive iterative dose reduction with wide-volume acquisition on 320-detector CT. Eur Radiol 2012; 22 (02) 295-301
  • 63 Yu L, Christner JA, Leng S, Wang J, Fletcher JG, McCollough CH. Virtual monochromatic imaging in dual-source dual-energy CT: radiation dose and image quality. Med Phys 2011; 38 (12) 6371-6379
  • 64 Glazebrook KN, Guimarães LS, Murthy NS. , et al. Identification of intraarticular and periarticular uric acid crystals with dual-energy CT: initial evaluation. Radiology 2011; 261 (02) 516-524
  • 65 Pache G, Krauss B, Strohm P. , et al. Dual-energy CT virtual noncalcium technique: detecting posttraumatic bone marrow lesions—feasibility study. Radiology 2010; 256 (02) 617-624
  • 66 Ai S, Qu M, Glazebrook KN. , et al. Use of dual-energy CT and virtual non-calcium techniques to evaluate post-traumatic bone bruises in knees in the subacute setting. Skeletal Radiol 2014; 43 (09) 1289-1295
  • 67 Jans L, De Kock I, Herregods N. , et al. Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis. Ann Rheum Dis 2018; 77 (06) 958-960
  • 68 Wang CK, Tsai JM, Chuang MT, Wang MT, Huang KY, Lin RM. Bone marrow edema in vertebral compression fractures: detection with dual-energy CT. Radiology 2013; 269 (02) 525-533
  • 69 Reddy T, McLaughlin PD, Mallinson PI. , et al. Detection of occult, undisplaced hip fractures with a dual-energy CT algorithm targeted to detection of bone marrow edema. Emerg Radiol 2015; 22 (01) 25-29
  • 70 Meinel FG, Bischoff B, Zhang Q, Bamberg F, Reiser MF, Johnson TRC. Metal artifact reduction by dual-energy computed tomography using energetic extrapolation: a systematically optimized protocol. Invest Radiol 2012; 47 (07) 406-414
  • 71 Pessis E, Campagna R, Sverzut J-M. , et al. Virtual monochromatic spectral imaging with fast kilovoltage switching: reduction of metal artifacts at CT. Radiographics 2013; 33 (02) 573-583
  • 72 Dabirrahmani D, Magnussen J, Appleyard RC. Dual-energy computed tomography—how accurate is gemstone spectrum imaging metal artefact reduction? its application to orthopedic metal implants. J Comput Assist Tomogr 2015; 39 (06) 925-935
  • 73 Peltola EK, Koskinen SK. Dual-energy computed tomography of cruciate ligament injuries in acute knee trauma. Skeletal Radiol 2015; 44 (09) 1295-1301
  • 74 Zheng S, Dong Y, Miao Y. , et al. Differentiation of osteolytic metastases and Schmorl's nodes in cancer patients using dual-energy CT: advantage of spectral CT imaging. Eur J Radiol 2014; 83 (07) 1216-1221
  • 75 Dong Y, Zheng S, Machida H. , et al. Differential diagnosis of osteoblastic metastases from bone islands in patients with lung cancer by single-source dual-energy CT: advantages of spectral CT imaging. Eur J Radiol 2015; 84 (05) 901-907
  • 76 Koivisto J, Kiljunen T, Kadesjö N, Shi XQ, Wolff J. Effective radiation dose of a MSCT, two CBCT and one conventional radiography device in the ankle region. J Foot Ankle Res 2015; 8 (01) 8
  • 77 Edlund R, Skorpil M, Lapidus G, Bäcklund J. Cone-beam CT in diagnosis of scaphoid fractures. Skeletal Radiol 2016; 45 (02) 197-204
  • 78 Suojärvi N, Haapamäki V, Lindfors N, Koskinen SK. Radiocarpal injuries: cone beam computed tomography arthrography, magnetic resonance arthrography, and arthroscopic correlation among 21 patients. Scand J Surg 2017; 106 (02) 173-179
  • 79 Gondim Teixeira PA, Gervaise A, Louis M. , et al. Musculoskeletal wide detector CT: principles, techniques and applications in clinical practice and research. Eur J Radiol 2015; 84 (05) 892-900
  • 80 Wassilew GI, Janz V, Heller MO. , et al. Real time visualization of femoroacetabular impingement and subluxation using 320-slice computed tomography. J Orthop Res 2013; 31 (02) 275-281
  • 81 Shores JT, Demehri S, Chhabra A. Kinematic “4 dimensional” CT imaging in the assessment of wrist biomechanics before and after surgical repair. Eplasty 2013; 13: e9
  • 82 Gillet R, Teixeira P, Meyer JB. , et al. Dynamic CT angiography for the diagnosis of patients with thoracic outlet syndrome: correlation with patient symptoms. J Cardiovasc Comput Tomogr 2018; 12 (02) 158-165
  • 83 Demehri S, Hafezi-Nejad N, Morelli JN. , et al. Scapholunate kinematics of asymptomatic wrists in comparison with symptomatic contralateral wrists using four-dimensional CT examinations: initial clinical experience. Skeletal Radiol 2016; 45 (04) 437-446
  • 84 Sharpe RE, Nazarian LN, Parker L, Rao VM, Levin DC. Dramatically increased musculoskeletal ultrasound utilization from 2000 to 2009, especially by podiatrists in private offices. J Am Coll Radiol 2012; 9 (02) 141-146
  • 85 Chimenti RL, Flemister AS, Tome J. , et al. Altered tendon characteristics and mechanical properties associated with insertional Achilles tendinopathy. J Orthop Sports Phys Ther 2014; 44 (09) 680-689
  • 86 Tan S, Kudaş S, Özcan AŞ. , et al. Real-time sonoelastography of the Achilles tendon: pattern description in healthy subjects and patients with surgically repaired complete ruptures. Skeletal Radiol 2012; 41 (09) 1067-1072
  • 87 Cingoz M, Kandemirli SG, Alis DC, Samanci C, Kandemirli GC, Adatepe NU. Evaluation of median nerve by shear wave elastography and diffusion tensor imaging in carpal tunnel syndrome. Eur J Radiol 2018; 101: 59-64
  • 88 Dikici AS, Ustabasioglu FE, Delil S. , et al. Evaluation of the tibial nerve with shear-wave elastography: a potential sonographic method for the diagnosis of diabetic peripheral neuropathy. Radiology 2017; 282 (02) 494-501
  • 89 Sadeghi S, Newman C, Cortes DH. Change in skeletal muscle stiffness after running competition is dependent on both running distance and recovery time: a pilot study. PeerJ 2018; 6: e4469
  • 90 Aşkın A, Kalaycı ÖT, Bayram KB. , et al. Strain sonoelastographic evaluation of biceps muscle intrinsic stiffness after botulinum toxin-A injection. Top Stroke Rehabil 2017; 24 (01) 12-17
  • 91 Ohrndorf S, Hensch A, Naumann L. , et al. Contrast-enhanced ultrasonography is more sensitive than grayscale and power Doppler ultrasonography compared to MRI in therapy monitoring of rheumatoid arthritis patients. Ultraschall Med 2011; 32 (Suppl. 02) E38-E44
  • 92 Lassau N, Chami L, Chebil M. , et al. Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenic treatments. Discov Med 2011; 11 (56) 18-24
  • 93 Tranquart F, Correas JM, Ladam Marcus V. , et al. Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study. [in French]. J Radiol 2009; 90 (1 Pt 2): 109-122
  • 94 De Marchi A, Prever EBD, Cavallo F. , et al. Perfusion pattern and time of vascularisation with CEUS increase accuracy in differentiating between benign and malignant tumours in 216 musculoskeletal soft tissue masses. Eur J Radiol 2015; 84 (01) 142-150
  • 95 De Marchi A, Brach del Prever EM, Linari A. , et al. Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours. Eur Radiol 2010; 20 (11) 2740-2748
  • 96 Gulati M, Hu JS, Desai B, Hwang DH, Grant EG, Duddalwar VA. Contrast-enhanced sonography for monitoring neoadjuvant chemotherapy in soft tissue sarcomas. J Ultrasound Med 2015; 34 (08) 1489-1499
  • 97 Artul S, Nseir W, Armaly Z, Soudack M. Superb microvascular imaging: added value and novel applications. J Clin Imaging Sci 2017; 7: 45
  • 98 Yokota K, Tsuzuki Wada T, Akiyama Y, Mimura T. Detection of synovial inflammation in rheumatic diseases using superb microvascular imaging: comparison with conventional power Doppler imaging. Mod Rheumatol 2018; 28 (02) 327-333
  • 99 Arslan S, Karahan AY, Oncu F, Bakdik S, Durmaz MS, Tolu I. Diagnostic performance of superb microvascular imaging and other sonographic modalities in the assessment of lateral epicondylosis. J Ultrasound Med 2018; 37 (03) 585-593
  • 100 Chen J, Chen L, Wu L. , et al. Value of superb microvascular imaging ultrasonography in the diagnosis of carpal tunnel syndrome: compared with color Doppler and power Doppler. Medicine (Baltimore) 2017; 96 (21) e6862
  • 101 van Schie HTM, de Vos RJ, de Jonge S. , et al. Ultrasonographic tissue characterisation of human Achilles tendons: quantification of tendon structure through a novel non-invasive approach. Br J Sports Med 2010; 44 (16) 1153-1159
  • 102 Docking SI, Rosengarten SD, Cook J. Achilles tendon structure improves on UTC imaging over a 5-month pre-season in elite Australian football players. Scand J Med Sci Sports 2016; 26 (05) 557-563
  • 103 Klauser AS, De Zordo T, Feuchtner GM. , et al. Fusion of real-time US with CT images to guide sacroiliac joint injection in vitro and in vivo. Radiology 2010; 256 (02) 547-553
  • 104 Wong-On M, Til-Pérez L, Balius R. Evaluation of MRI-US fusion technology in sports-related musculoskeletal injuries. Adv Ther 2015; 32 (06) 580-594
  • 105 Burke CJ, Bencardino J, Adler R. The potential use of ultrasound-magnetic resonance imaging fusion applications in musculoskeletal intervention. J Ultrasound Med 2017; 36 (01) 217-224
  • 106 Szkudlarek M, Terslev L, Wakefield RJ. , et al. Summary findings of a systematic literature review of the ultrasound assessment of bone erosions in rheumatoid arthritis. J Rheumatol 2016; 43 (01) 12-21
  • 107 Iagnocco A, Finucci A, Ceccarelli F, Perricone C, Iorgoveanu V, Valesini G. Power Doppler ultrasound monitoring of response to anti-tumour necrosis factor alpha treatment in patients with rheumatoid arthritis. Rheumatology (Oxford) 2015; 54 (10) 1890-1896
  • 108 Chen KC, Lin AC, Chong CF, Wang TL. An overview of point-of-care ultrasound for soft tissue and musculoskeletal applications in the emergency department. J Intensive Care 2016; 4 (01) 55
  • 109 Royal Philips. Available at: https://www.philips.com/a-w/about/news/archive/standard/news/press/2017/20171010-psv-soccer-club-is-first-in-the-world-to-use-philips-lumify-portable-ultrasound-to-evaluate-its-players-injuries.html
  • 110 Garcia KM, Harrison MF, Sargsyan AE, Ebert D, Dulchavsky SA. Real-time ultrasound assessment of astronaut spinal anatomy and disorders on the international space station. J Ultrasound Med 2018; 37 (04) 987-999
  • 111 Parthipun A, Moser J, Mok W, Paramithas A, Hamilton P, Sott AH. 99mTc-HDP SPECT-CT aids localization of joint injections in degenerative joint disease of the foot and ankle. Foot Ankle Int 2015; 36 (08) 928-935
  • 112 Meftah M, Katchis SD, Scharf SC, Mintz DN, Klein DA, Weiner LS. SPECT/CT in the management of osteochondral lesions of the talus. Foot Ankle Int 2011; 32 (03) 233-238
  • 113 Upadhyay B, Mo J, Beadsmoore C, Marshall T, Toms A, Buscombe J. Technetium-99m methylene diphosphonate single-photon emission computed tomography/computed tomography of the foot and ankle. World J Nucl Med 2017; 16 (02) 88-100
  • 114 Horger M, Eschmann SM, Pfannenberg C. , et al. Added value of SPECT/CT in patients suspected of having bone infection: preliminary results. Arch Orthop Trauma Surg 2007; 127 (03) 211-221
  • 115 Al-Nabhani K, Michopoulou S, Allie R. , et al. Painful knee prosthesis: can we help with bone SPECT/CT?. Nucl Med Commun 2014; 35 (02) 182-188
  • 116 Bhure U, Roos JE, Pérez Lago MDS. , et al. SPECT/CT arthrography. Br J Radiol 2018; 91 (1082): 20170635
  • 117 Nakajima K, Edenbrandt L, Mizokami A. Bone scan index: a new biomarker of bone metastasis in patients with prostate cancer. Int J Urol 2017; 24 (09) 668-673
  • 118 Dennis ER, Jia X, Mezheritskiy IS. , et al. Bone scan index: a quantitative treatment response biomarker for castration-resistant metastatic prostate cancer. J Clin Oncol 2012; 30 (05) 519-524
  • 119 Mitsui Y, Shiina H, Yamamoto Y. , et al. Prediction of survival benefit using an automated bone scan index in patients with castration-resistant prostate cancer. BJU Int 2012; 110 (11 Pt B) E628-E634
  • 120 Etchebehere EC, Hobbs BP, Milton DR. , et al. Assessing the role of 18F-FDG PET and 18F-FDG PET/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 2016; 43 (05) 860-870
  • 121 Hongtao L, Hui Z, Bingshun W. , et al. 18F-FDG positron emission tomography for the assessment of histological response to neoadjuvant chemotherapy in osteosarcomas: a meta-analysis. Surg Oncol 2012; 21 (04) e165-e170
  • 122 Johnson GR, Zhuang H, Khan J, Chiang SB, Alavi A. Roles of positron emission tomography with fluorine-18-deoxyglucose in the detection of local recurrent and distant metastatic sarcoma. Clin Nucl Med 2003; 28 (10) 815-820
  • 123 Jambor I, Kuisma A, Ramadan S. , et al. Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial. Acta Oncol 2016; 55 (01) 59-67
  • 124 Ovadia D, Metser U, Lievshitz G, Yaniv M, Wientroub S, Even-Sapir E. Back pain in adolescents: assessment with integrated 18F-fluoride positron-emission tomography-computed tomography. J Pediatr Orthop 2007; 27 (01) 90-93
  • 125 Kumar V, Boddeti DK. (68)Ga-radiopharmaceuticals for PET imaging of infection and inflammation. Recent Results Cancer Res 2013; 194: 189-219
  • 126 Nielsen OL, Afzelius P, Bender D. , et al. Comparison of autologous (111)In-leukocytes, (18)F-FDG, (11)C-methionine, (11)C-PK11195 and (68)Ga-citrate for diagnostic nuclear imaging in a juvenile porcine haematogenous Staphylococcus aureus osteomyelitis model. Am J Nucl Med Mol Imaging 2015; 5 (02) 169-182
  • 127 Wieder HA, Pomykala KL, Benz MR, Buck AK, Herrmann K. PET tracers in musculoskeletal disease beyond FDG. Semin Musculoskelet Radiol 2014; 18 (02) 123-132
  • 128 Tateishi U, Yamaguchi U, Maeda T. , et al. Staging performance of carbon-11 choline positron emission tomography/computed tomography in patients with bone and soft tissue sarcoma: comparison with conventional imaging. Cancer Sci 2006; 97 (10) 1125-1128
  • 129 Fuccio C, Castellucci P, Schiavina R. , et al. Role of 11C-choline PET/CT in the re-staging of prostate cancer patients with biochemical relapse and negative results at bone scintigraphy. Eur J Radiol 2012; 81 (08) e893-e896
  • 130 Perera M, Papa N, Christidis D. , et al. Sensitivity, specificity, and predictors of positive 68Ga-prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysis. Eur Urol 2016; 70 (06) 926-937
  • 131 Janssen JC, Meißner S, Woythal N. , et al. Comparison of hybrid 68Ga-PSMA-PET/CT and 99mTc-DPD-SPECT/CT for the detection of bone metastases in prostate cancer patients: additional value of morphologic information from low dose CT. Eur Radiol 2018; 28 (02) 610-619
  • 132 Hirsch FW, Sattler B, Sorge I. , et al. PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner. Pediatr Radiol 2013; 43 (07) 860-875
  • 133 Catalano OA, Rosen BR, Sahani DV. , et al. Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study. Radiology 2013; 269 (03) 857-869
  • 134 Sachpekidis C, Hillengass J, Goldschmidt H. , et al. Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma. Am J Nucl Med Mol Imaging 2015; 5 (05) 469-478
  • 135 Kobayashi N, Inaba Y, Tateishi U. , et al. Comparison of 18F-fluoride positron emission tomography and magnetic resonance imaging in evaluating early-stage osteoarthritis of the hip. Nucl Med Commun 2015; 36 (01) 84-89
  • 136 Hayashi D, Roemer FW, Katur A. , et al. Imaging of synovitis in osteoarthritis: current status and outlook. Semin Arthritis Rheum 2011; 41 (02) 116-130
  • 137 Zeman MN, Scott PJ. Current imaging strategies in rheumatoid arthritis. Am J Nucl Med Mol Imaging 2012; 2 (02) 174-220
  • 138 Imamoto N, Momosaki S, Fujita M. , et al. [11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats. Neuroimage 2013; 79: 121-128