Abstract
Neuropathic pain management is challenging, and typically requires a multifaceted
approach. There are several treatment options, both pharmacologic and nonpharmacologic.
Of the available pharmacologic agents, those with the strongest supporting evidence
include tricyclic antidepressants, serotonin–norepinephrine reuptake inhibitors, and
certain antiseizure agents. There is emerging evidence for the use of cannabinoids,
but conclusive studies are not available. Nonpharmacologic therapies that have been
utilized in the management of neuropathic pain include acupuncture, massage therapy,
and reflexology. Despite their use as adjunctive therapies in clinical practice, the
current evidence supporting their use is not strong. For the management of neuropathic
pain, combination therapies are generally employed. Additional studies for emerging
therapies are still needed.
Keywords
tricyclics - cannabinoids - ketamine - acupuncture
