Abstract
Purpose This study was aimed to assess the accurate incidence of renal stones in severely
disabled children treated with topiramate (TPM).
Method We reviewed the medical records of severely disabled children with epilepsy under
15 years old who underwent radiological examinations to investigate urinary stones.
The study enrolled 26 patients who were divided into two groups. One group had been
treated with TPM for at least 1 year and the other had not been treated with TPM,
zonisamide, acetazolamide, or other diuretic drugs. We collected parameters from the
medical records and compared the groups.
Results All participants were evaluated radiologically, with computed tomography (CT) in
two patients, ultrasonography in 22 patients, and both in two. No patient had any
morphological abnormality of the kidneys and history of urinary tract infection. There
were no significant differences in sex, age, body weight, or feeding manner between
the groups, while the incidence of renal stones or calcifications was significantly
higher in the TPM-treated group (60 vs. 0%; p = 0.00241).
Conclusion There is a high incidence of renal stone formation in severely disabled children
treated with TPM.
Keywords
severely disabled children with epilepsy - antiepileptic drug - topiramate - renal
stone - nonambulatory children
