Abstract
Aggregate data in institutional antibiograms may not accurately represent major pathogens'
antibiotic susceptibility patterns in important clinical scenarios. In this analysis
of Staphylococcus aureus isolates between 2013 and 2016 at the Women and Children's Hospital of Buffalo, methicillin
and clindamycin susceptibility rates of S. aureus differed significantly from aggregate data when stratified by wound specimen and
osteoarticular infection (OAI) isolates. Clindamycin susceptibility of methicillin-resistant
S. aureus (MRSA) in wound specimens was higher than published antibiograms, whereas the proportion
of MRSA and total clindamycin susceptibility in OAI was relatively lower, which impacts
empiric antibiotic decision-making. With S. aureus antibiotic susceptibility patterns shifting and differences by infection type, as
well as geographic location, pediatric facilities are encouraged to perform local
reviews and emphasize specimen and clinical-context rather than aggregate antibiograms.
Keywords
antibiograms -
Staphylococcus aureus susceptibilities - clindamycin-resistant
Staphylococcus aureus
