Successful Management of Adolescent Bupropion Overdose with Intravenous Lipid Emulsion Therapy

Kasha Bornstein; Tim Montrief; Mehruba Anwar Parris

doi:10.1055/s-0039-1693483

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2019; 08(04): 242-246
DOI: 10.1055/s-0039-1693483

Case Report

Georg Thieme Verlag KG Stuttgart · New York

Successful Management of Adolescent Bupropion Overdose with Intravenous Lipid Emulsion Therapy

Authors

Kasha Bornstein

¹University of Miami Miller School of Medicine, Miami, Florida, United States
Tim Montrief

²Department of Emergency Medicine, University of Miami, Jackson Memorial Hospital/Miller School of Medicine, Miami, United States
Mehruba Anwar Parris

²Department of Emergency Medicine, University of Miami, Jackson Memorial Hospital/Miller School of Medicine, Miami, United States

Abstract

Bupropion overdose in the pediatric setting poses significant potential for toxicity. We present the case of a 15-year-old female patient presenting with intentional bupropion overdose resulting in generalized tonic–clonic seizures, severe acidosis, vomiting, and tachycardia after ingestion of between 1,650 to 9,000 mg (24–133 mg/kg) of bupropion. The patient was admitted to pediatric intensive care unit (PICU) where toxicity was resolved promptly following administration of intravenous lipid emulsion (ILE) infusion. ILE is a first-line treatment for other forms of toxicity including unintended local anesthetic administration. ILE use is not a first-line treatment in this setting, but this case presents a positive subsequent patient outcome.

Keywords

Bupropion - Wellbutrin - lipid emulsion therapy - antidepressant - overdose

Full Text

References

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