CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2019; 08(03): 211-215
DOI: 10.1055/s-0039-1698847
Case Report
Neurological Surgeons' Society of India

Sellar Colloid Cyst—An Anatomically Aberrant and Diagnostically Challenging Entity: Report of a Rare Case with Literature Review

Syed Asmat Ali
1   Department of Neurosurgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
,
Kavita Gaur
2   Department of Pathology, GB Pant Institute of Postgraduate Medical Education and Research, New Delhi, India
3   Department of Pathology, Lady Hardinge Medical College, New Delhi
,
Arvind Kumar Srivastava
4   Department of Neurosurgery, GB Pant Institute of Postgraduate Medical Education and Research and associated Maulana Azad Medical College, New Delhi, India
,
Ravindra Kumar Saran
2   Department of Pathology, GB Pant Institute of Postgraduate Medical Education and Research, New Delhi, India
› Author Affiliations
Further Information

Address for correspondence

Kavita Gaur, MD, DNB
Department of Pathology, Lady Hardinge Medical College
New Delhi 110001
India   

Publication History

Received: 26 February 2019

Accepted: 25 April 2019

Publication Date:
15 November 2019 (online)

 

Abstract

The sellar colloid cyst is a rare entity anatomically occurring at the intermediate lobe of the pituitary gland. Clinically a cystic sellar lesion with pressure effects usually evokes the suspicion of a pituitary adenoma. We present the case of a middle-aged woman presenting with visual diminution and bilateral optic atrophy, caused by a large sellar lesion, variably intense on magnetic resonance imaging (MRI). The subsequent histologic diagnosis of a colloid cyst was unexpected. This report highlights the subtle intraoperative and diagnostic features key to diagnosing this rarity. We also discuss a practical differential diagnostic approach relevant to the practicing surgeon and review the existing literature.


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Introduction

Colloid cyst (CC) is an uncommon non-neoplastic lesion characteristically situated at the third ventricle.[1] The occurrence of this entity at the sella is rare and comprises less than 0.5% of resected sellar lesions.[2] Diagnostic dilemma with pituitary adenoma and other cystic sellar-suprasellar lesions is likely. Multidisciplinary correlation is essential to nail the correct diagnosis. We present the case of a 50-year-old woman presenting with headache and visual diminution whose imaging findings suggested a pituitary adenoma. Subsequent histopathology revealed the presence of a CC contrary to our preoperative assumption of a pituitary neoplasm. We also discuss possible differential diagnoses based on clinical imaging and pathologic assessment.


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Case Report

A 50-year-old woman presented with episodic headache for 3 years. This was moderate in intensity, initially bitemporal gradually becoming holocranial, and relieved with analgesics. She also developed painless progressive diminution of vision in both the eyes for the previous 6 months (especially for the outer halves of both visual fields). There was no history of fever, vomiting, seizures, trauma, or loss of consciousness. No significant past history was elicited. Ocular examination revealed a visual acuity of 6/24 in the left eye and 6/18 in the right eye, with bitemporal hemianopia and bilateral optic atrophy on funduscopy. Neurologic examination was unremarkable. Contrast-enhancing computed tomography (CECT) scan of the head revealed a homogeneously enhancing hyperdense mass in the sella causing sellar expansion, extending into the suprasellar region. Magnetic resonance imaging (MRI) showed a smooth marginated, bilobed mass lesion 3.2 × 3.1 × 2.6 cm in dimension arising from the sella with suprasellar extension compressing the optic chiasm and involving the infundibulum. The lesion was isointense on T1-weighted image (T1WI) and iso-hyperintense on T2-weighted image (T2WI) ([Fig. 1a] [c]), hyperintense on fluid attenuation inversion recovery (FLAIR) sequence, and nonenhancing with contrast. Radiologic impression suggested a pituitary macroadenoma. Endocrine evaluation (thyroid function tests, serum cortisol, prolactin, growth hormone [GH], luteinizing hormone [LH], follicle-stimulating hormone [FSH], adrenocorticotropic hormone [ACTH], insulin-like growth factor 1 [IGF1]) was normal. Tests for assessing the functional status of the posterior pituitary to rule out diabetes insipidus (including fluid deprivation test) were performed and were unremarkable. A preoperative working diagnosis of nonsecretory pituitary adenoma was made. The lesion was excised via a transnasal, transsphenoidal approach. Perioperatively, the lesion was grayish and contained mucoid material. Histopathologic examination revealed amorphous eosinophilic periodic acid–Schiff (PAS)–positive material with focal fibrous tissue compatible with a CC ([Fig. 2]). Postoperative period was uneventful. Follow-up CT 1 year later revealed complete absence of the lesion and the presence of shrunken pituitary gland at the sella ([Fig. 1d]). The patient is currently doing well and is free of neurologic or endocrinologic deficits.

Zoom Image
Fig. 1 (a) T1 axial image of MRI of the brain showing an isointense circular lesion abutting the surrounding cistern compressing the optic chiasma. (b) T1 contrast (coronal view) of MRI of the brain showing nonenhancing pituitary mass abutting the suprasellar cistern and third ventricle with slight pseudocapsule displaying delayed contrast enhancement. (c) T2-weighted image showing isointense well-circumscribed lesion in sellar region. (d) Computed tomography of the brain (sagittal view) showing absence of the lesion at 1 year of follow-up.
Zoom Image
Fig. 2 (a) Photomicrograph of the resected cyst histologically displaying amorphous eosinophilic colloid like material (H&E, 200×) (b) Focal fibrous tissue (arrow) devoid of epithelium forms the lining (PAS, 200×). The colloid-like material is periodic acid–Schiff–positive (inset) (PAS, 400×).

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Discussion

Cystic sellar lesions invariably present a diagnostic and therapeutic challenge for the neurosurgeon. Such cysts may be classified variously as functional/nonfunctional (on the basis of hormonal secretion), symptomatic/nonsymptomatic, and as neoplastic (pituitary adenoma and craniopharyngioma) or non-neoplastic pars intermedia, Rathke’s cleft, arachnoid, and miscellaneous.[3] [4] [5]

The most common location of CC is the anterior part of the third ventricle.[1] Other sites are the brainstem, cerebellum, pia mater, and fourth ventricle.[4] CC in the sellar region is rare as seen in this case where it was detected at the pars intermedia. Descriptions of sellar CC are extremely rare in the medical literature, with only a few published works describing clinical presentation.[4] [5] [6] [7] The exact pathogenesis of this entity lacks clarity. Possible theories include degenerative processes and/or vascular insults.[5] Sellar CC unlike similar cysts seen at the third ventricle are devoid of epithelium and are considered by some as pseudocysts.[8]

Presentation at aberrant anatomical locations often delays diagnosis. Hence, a combined approach including CT, MRI, and histopathology is favored to diagnose these lesions. Cystic lesions in the sellar region may evoke a number of diagnostic possibilities, including Rathke’s cleft cyst, cystic pituitary adenoma, craniopharyngioma, arachnoid cyst, and epidermoid cyst ([Table 1]).[9] On CT, most sellar cysts are hypodense except the CC that is usually hyperdense as seen in our case and is nonenhancing on contrast.[4] Findings on MRI are variable. On T1WI one-half of the cases are hyperintense, and the rest are iso- or hypointense. On T2WI, most CCs show iso- to hypointensity whereas FLAIR sequences reveal increased signal intensity. This variation is attributed to paramagnetic effects of metal ions in the cyst fluid, variable protein content, and hemorrhage.[1] [10] Our case was isointense on T1, iso-hyperintense on T2, and hyperintense on FLAIR. Though hyperintensity on T2 is not usually seen in the CC, other T2 hyperintense lesions such as Rathke’s cyst, arachnoid, epidermoid cysts, and cystic pituitary adenomas have a characteristic histology, as outlined in [Table 1]. These histologic features were absent in this case, which showed colloid-like material on microscopy.

Table 1

The imaging-pathologic differential diagnosis of cystic sellar lesions[9] [11] [12]

Differential diagnosis

Usual age at presentation (decade)

Sex predilection

Usual CT findings

Common MRI findings (T1, T2, FLAIR)

Perioperative findings

Histopathologic findings

Abbreviations: CSF, cerebrospinal fluid; CT, computed tomography; DWI, diffusion-weighted imaging; F, female; FLAIR, fluid attenuation inversion recovery; M, male; MRI, magnetic resonance imaging.

Colloid cyst

3rd to 4th

M = F

Unilocular hyperdense cyst

T1: Variable but commonly isointense to hyperintense

T2: Low signal, iso to hypointense (depending upon protein content)

FLAIR: Low signal similar to CSF

No contrast enhancement

Mucoid material in cyst

Sellar lesions may be devoid of epithelium, periodic acid–Schiff–positive colloid-like material seen

Rathke’s cyst

2nd to 4th

F > M

Homogenous hypodense cyst

T1: Hyper- or hypointense

T2: Hyperintense

No contrast enhancement except thin peripheral enhancement

Intracystic nodule is indicative

Mucoid/rarely serous fluid

Simple/pseudostratified columnar epithelium with goblet cells, squamous metaplasia may be seen in the lining

Cystic pituitary adenoma

3rd, 6th

F > M

Hypodense cyst with surrounding wall enhancement

T1: Isointense to hypointense

T2: Hyperintense with wall enhancement

FLAIR: Isointense

Sometime mural nodule found

Pituitary gland not seen separately, intratumoral bleeding seen

Cystic change in a monomorphous proliferation of cells resembling normal pituicytes but devoid of acinar arrangement

Cystic craniopharyngioma

Bimodal: 1st peak at 1st decade, 2nd at 5th decade

No sex predilection

More extrasellar extension, hypodense with peripheral calcification

T1: Iso- to hyperintense

T2: Variable

Enhancement of wall noted

Machine oil with hard calcified capsule

Stratified squamous with wet keratin and cholesterol clefts and calcospherules in the adamantinoid type. pseudopapillae may be seen in the papillary type

Arachnoid cyst

4th to 5th decade

No sex predilection

Hypodense lesion with no enhancement

T1: Hypointense

T2: Hyperintense

No enhancement

No restriction on DWI

No solid component

Clear watery fluid

Cyst wall comprising fibrous connective tissue, lined by ovoid meningothelial cells

Epidermoid cyst

Middle aged

M > F

Hypodense lesion with no enhancement

T1: Hypointense

T2: Hyperintense

No enhancement

No restriction on DWI

Pultaceous material

Keratin flakes, squamous epithelium with keratohyaline layer

Clinical presentation of the sellar CC is insidious, and patients are often asymptomatic. However, large-sized cysts are likely to cause compression symptoms. Endocrinopathies may be a sequela of large cysts, a feature not seen in this case. Our patient, however, presented with visual diminution and bilateral optic atrophy presumably due to pressure effects.

Surgical treatment of CCs is warranted for symptomatic lesions causing compression induced endocrinologic and neurologic disturbances. The approach of choice is transnasal transsphenoidal with cyst decompression.[4] Glistening mucoid material in the resected cyst may alert the surgeon of this possibility. Excellent outcomes have been seen as in this case. Recurrence is rare in the context of this entity.[1]


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Conclusion

The sellar CC is an uncommon entity. Cystic pituitary lesions must be thoroughly evaluated pre-, peri- and postoperatively to arrive at a correct diagnosis. Variable MRI findings may confound the clinician.

In resource-constrained settings, the surgeon’s perioperative observations with good histopathologic assessment can minimize diagnostic delay. CC may be suspected intraoperatively based on the hint of mucoid material. Though confirmation is provided by histopathology, the astute surgeon should be aware of this entity, its gross presentation, and diagnostic challenges it poses.

Source(s) of Support in the Form of Grants, Equipment, Drugs, or All of These

None.


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Presentations at Meeting(s) and Conferences

None.


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Contribution of Each Author

  1. Syed Asmat Ali: Collection and analysis of data, literature review, drafting, and final approval of the manuscript.

  2. Kavita Gaur: Collection and analysis of data, literature review, image preparation, drafting, and final approval of the manuscript.

  3. Arvind Kumar Srivastava: Concept of work, clinical management, providing intellectual content of critical importance, editing, and final approval of the manuscript.

  4. Ravindra Kumar Saran: Concept of work, histopathologic analysis, providing intellectual content of critical importance, editing, and final approval of the manuscript.


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Declaration

The manuscript has been read and approved by all the authors, the requirements for authorship as stated earlier in this document have been met, and each author believes that the manuscript represents honest work.


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Conflicts of Interest

None.

Acknowledgment, if any

None.

* Department(s) and institution to which the work is credited: Departments of Pathology and Neurosurgery, GB Pant Institute of Postgraduate Medical Education and Research, New Delhi, India


  • References

  • 1 Armao D, Castillo M, Chen H, Kwock L. Colloid cyst of the third ventricle: imaging-pathologic correlation. AJNR Am J Neuroradiol 2000; 21 (08) 1470-1477
  • 2 Zada G, Lopes MBS, Srinivasan M, Laws ER. Colloid cysts of the sellar region. In: Zada G, Lopes MBS, Srinivasan M, Laws ER. eds An Atlas of Sellar and Parasellar Lesions: Clinical, Radiologic and Pathologic Correlations. Cham, Switzerland: Springer; 2016. 251
  • 3 Baskin DS, Wilson CB. Transsphenoidal treatment of non-neoplastic intrasellar cysts. A report of 38 cases. J Neurosurg 1984; 60 (01) 8-13
  • 4 Bladowska J, Bednarek-Tupikowska G, Biel A, Sąsiadek M. Colloid cyst of the pituitary gland: case report and literature review. Pol J Radiol 2010; 75 (02) 88-93
  • 5 Nomikos P, Buchfelder M, Fahlbusch R. Intra- and suprasellar colloid cysts. Pituitary 1999; 2 (02) 123-126
  • 6 Guduk M, Sun HI, Sav MA, Berkman Z. Pituitary colloid cyst. J Craniofac Surg 2017; 28: e166-e168
  • 7 Petrakakis I, Pirayesh A, Krauss JK, Raab P, Hartmann C, Nakamura M. The sellar and suprasellar region: a “hideaway” of rare lesions. Clinical aspects, imaging findings, surgical outcome and comparative analysis. Clin Neurol Neurosurg 2016; 149: 154-165
  • 8 Honegger J, Beshorner R, Ernemann U. Perisellar tumours including cysts, hamartomas and vascular tumours. In: Wass JAH, Stewart P. eds Oxford Textbook of Endocrinology and Diabetes. Oxford, UK:: Oxford University Press; 2011. 249
  • 9 Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws ER. Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 2010; 28 (04) E4
  • 10 Byun WM, Kim OL, Kim D. MR imaging findings of Rathke’s cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol 2000; 21 (03) 485-488
  • 11 Chowdhury FH, Haque MR, Sarker MH. Intracranial epidermoid tumor; microneurosurgical management: an experience of 23 cases. Asian J Neurosurg 2013; 8 (01) 21-28
  • 12 Redaelli de Zinis LO, Mortini P, Farina D, Mossi F. Expansile lesions arising from structures and spaces adjacent to the paranasal sinuses. In: Maroldi R, Nicolai P. eds Imaging in Treatment Planning for Sinonasal Diseases. Berlin, Germany: Springer; 2005. 221–247

Address for correspondence

Kavita Gaur, MD, DNB
Department of Pathology, Lady Hardinge Medical College
New Delhi 110001
India   

  • References

  • 1 Armao D, Castillo M, Chen H, Kwock L. Colloid cyst of the third ventricle: imaging-pathologic correlation. AJNR Am J Neuroradiol 2000; 21 (08) 1470-1477
  • 2 Zada G, Lopes MBS, Srinivasan M, Laws ER. Colloid cysts of the sellar region. In: Zada G, Lopes MBS, Srinivasan M, Laws ER. eds An Atlas of Sellar and Parasellar Lesions: Clinical, Radiologic and Pathologic Correlations. Cham, Switzerland: Springer; 2016. 251
  • 3 Baskin DS, Wilson CB. Transsphenoidal treatment of non-neoplastic intrasellar cysts. A report of 38 cases. J Neurosurg 1984; 60 (01) 8-13
  • 4 Bladowska J, Bednarek-Tupikowska G, Biel A, Sąsiadek M. Colloid cyst of the pituitary gland: case report and literature review. Pol J Radiol 2010; 75 (02) 88-93
  • 5 Nomikos P, Buchfelder M, Fahlbusch R. Intra- and suprasellar colloid cysts. Pituitary 1999; 2 (02) 123-126
  • 6 Guduk M, Sun HI, Sav MA, Berkman Z. Pituitary colloid cyst. J Craniofac Surg 2017; 28: e166-e168
  • 7 Petrakakis I, Pirayesh A, Krauss JK, Raab P, Hartmann C, Nakamura M. The sellar and suprasellar region: a “hideaway” of rare lesions. Clinical aspects, imaging findings, surgical outcome and comparative analysis. Clin Neurol Neurosurg 2016; 149: 154-165
  • 8 Honegger J, Beshorner R, Ernemann U. Perisellar tumours including cysts, hamartomas and vascular tumours. In: Wass JAH, Stewart P. eds Oxford Textbook of Endocrinology and Diabetes. Oxford, UK:: Oxford University Press; 2011. 249
  • 9 Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws ER. Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 2010; 28 (04) E4
  • 10 Byun WM, Kim OL, Kim D. MR imaging findings of Rathke’s cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol 2000; 21 (03) 485-488
  • 11 Chowdhury FH, Haque MR, Sarker MH. Intracranial epidermoid tumor; microneurosurgical management: an experience of 23 cases. Asian J Neurosurg 2013; 8 (01) 21-28
  • 12 Redaelli de Zinis LO, Mortini P, Farina D, Mossi F. Expansile lesions arising from structures and spaces adjacent to the paranasal sinuses. In: Maroldi R, Nicolai P. eds Imaging in Treatment Planning for Sinonasal Diseases. Berlin, Germany: Springer; 2005. 221–247

Zoom Image
Fig. 1 (a) T1 axial image of MRI of the brain showing an isointense circular lesion abutting the surrounding cistern compressing the optic chiasma. (b) T1 contrast (coronal view) of MRI of the brain showing nonenhancing pituitary mass abutting the suprasellar cistern and third ventricle with slight pseudocapsule displaying delayed contrast enhancement. (c) T2-weighted image showing isointense well-circumscribed lesion in sellar region. (d) Computed tomography of the brain (sagittal view) showing absence of the lesion at 1 year of follow-up.
Zoom Image
Fig. 2 (a) Photomicrograph of the resected cyst histologically displaying amorphous eosinophilic colloid like material (H&E, 200×) (b) Focal fibrous tissue (arrow) devoid of epithelium forms the lining (PAS, 200×). The colloid-like material is periodic acid–Schiff–positive (inset) (PAS, 400×).