Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report

Anthony Grondin; Eloïse Baudou; Marlène Pasquet; Sonia Pelluau; Karim Jamal-Bey; Cécile Bermot; Frederic Villega; Emmanuel Cheuret

doi:10.1055/s-0039-3402011

Neuropediatrics, Inhaltsverzeichnis

Neuropediatrics 2020; 51(03): 221-224
DOI: 10.1055/s-0039-3402011

Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report

Anthony Grondin

¹Neonatal Unit, Department of Paediatrics, CHU of Reunion Island, Northern Hospital Group, Saint-Denis, France

,

Eloïse Baudou

²Neurology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France

,

Marlène Pasquet

³Immunology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France

,

Sonia Pelluau

⁴Pediatric Intensive Care, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France

,

Karim Jamal-Bey

⁵Cardiology Unit, Department of Paediatrics, CHU of Reunion Island, Southern Hospital Group, Réunion, France

,

Cécile Bermot

⁶Department of Radiology, Georges POMPIDOU Hospital, Paris, France

,

Frederic Villega

⁷Neurology Unit, Department of Paediatrics, CHU of Bordeaux, Aquitaine, France

,

Emmanuel Cheuret

⁸Neurology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France

› Institutsangaben

Abstract

Seventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment. Cerebral lesions highlighted on the MRI scan are specific to the neonatal period and impact long-term prognosis. The likely genetic predisposition in this case is interesting and requires further investigation. In addition, this case raises questions about the duration of oral acyclovir suppressive therapy.

Keywords

recurrence of CNS disease - neonatal HSV infection - suppressive therapy

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Referenzen

References
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