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Dtsch Med Wochenschr 2015; 140(01): 19-23
DOI: 10.1055/s-0040-100425
Dossier
Adipositas
© Georg Thieme Verlag KG Stuttgart · New York

Adipositas – wie sie entsteht und welche Folgen sie hat

Obesity: Causes and consequences
Alexandra Willms
1   Klinik für Endokrinologie, Diabetologie und Angiologie, Städtisches Klinikum, München-Bogenhausen
,
Thorsten Siegmund
1   Klinik für Endokrinologie, Diabetologie und Angiologie, Städtisches Klinikum, München-Bogenhausen
,
Petra-Maria Schumm-Draeger
1   Klinik für Endokrinologie, Diabetologie und Angiologie, Städtisches Klinikum, München-Bogenhausen
› Author Affiliations
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Publication History

Publication Date:
12 January 2015 (online)

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Nahezu jeder vierte Deutsche ist zu dick – Tendenz zunehmend. Die Ursachen sind hinlänglich bekannt: zuviel Essen, zu wenig Bewegung. In Einzelfällen können aber auch weitere Erkrankungen dahinter stecken. Lesen Sie, welche Folgen das zu hohe Körpergewicht für die Patienten haben kann, und was Sie ausschließen müssen, bevor Sie zur Diät raten.

Schlüsselwörter

Risikofaktoren - Diagnostik - Adipositas

Key Words

risk factors - diagnostics - obesity
 

  • Literaturverzeichnis

  • 1 Banim PJ, Luben RN, Bullock H et al. The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk). Eur J Gastroenterol Hepatol 2011; 23: 733
    CrossrefPubMedGoogle Scholar
  • 2 Blüher M. Das Fettgewebe – ein endokrines Organ. Der Internist 2014; 55: 687-697
    CrossrefPubMedGoogle Scholar
  • 3 Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625-1638
    CrossrefPubMedGoogle Scholar
  • 4 Despres JP, Lemieux I, Prud’homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ 2001; 322: 716-720
    CrossrefPubMedGoogle Scholar
  • 5 Dieterle C, Landgraf R. Folgeerkrankungen und Komplikationen der Adipositas. Internist 2006; 47: 141-149
    CrossrefPubMedGoogle Scholar
  • 6 Farooqi IS, Keogh JM, Yeo GS et al. Clinical spectrum of obesity and mutations in the Melanocortin 4 Receptor Gene. N Engl J Med 2003; 348: 1085-1095
    CrossrefPubMedGoogle Scholar
  • 7 Fasshauer M, Klein J, Blüher M, Paschke R. Adipokine: Mögliches Bindeglied zwischen Insulinresistenz und Adipositas. Dtsch Arztebl 2004; 101: 51-52
    PubMedGoogle Scholar
  • 8 Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 2013; 309: 71-82
    CrossrefPubMedGoogle Scholar
  • 9 Foster GD, Sanders MH, Millman R et al. Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care 2009; 32: 1017-1019
    CrossrefPubMedGoogle Scholar
  • 10 Gregg EW, Cheng YJ, Narayan KM et al. The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976–2004. Prev Med 2007; 45: 348-352
    CrossrefPubMedGoogle Scholar
  • 11 Groß AF, Fickert S, Günther KP. Übergewicht und Arthrose. Orthopäde 2005; 34: 638-644
    CrossrefPubMedGoogle Scholar
  • 12 Guh DP, Zhang W, Bansback N et al. The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9: 88
    CrossrefPubMedGoogle Scholar
  • 13 Gustafson DR. Adiposity hormones and dementia. Journal of the Neurological Sciences 2010 299: 30-34
    PubMedGoogle Scholar
  • 14 Hammoud OA, Meikle AW, Reis LO et al. Obesity and male infertility. A Practical Approach. Semin Reprod Med 2012; 30: 486-495
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Hampel H, Abraham NS, El-Seraq HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143: 199-211
    CrossrefPubMedGoogle Scholar
  • 16 Hein H. Herz-Kreislauferkrankungen und schlafbezogene obstruktive Atmungsstörungen. Pneumonologie 2004; 58: 505-509
    PubMedGoogle Scholar
  • 17 Helmert U, Strube H. Die Entwicklung der Adipositas in Deutschland im Zeitraum von 1985–2002. Gesundheitswesen 2004; 66: 409-415
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Lazo M, Hernaez R, Eberhardt MS et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 2013; 178: 38-45
    CrossrefPubMedGoogle Scholar
  • 19 Ley RE et al. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-1023
    CrossrefPubMedGoogle Scholar
  • 20 Luppino FS, de Wit LM, Bouvy PF et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 2010; 67: 220-229
    Google Scholar
  • 21 Mokdad AH, Ford ES, Bowman BA et al. Diabetes trends in the U.S.: 1990–1998. Diabetes Care 2000; 23: 1278-1283
    CrossrefPubMedGoogle Scholar
  • 22 Mozaffarian D, Hao T, Rimm EB et al. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med 2011; 364: 2392
    CrossrefPubMedGoogle Scholar
  • 23 Murphy EF, Clarke SF, Marques TM et al. Antimicrobials: Strategies for targeting obesity and metabolic health?. Gut Microbes 2013; 4: 48
    CrossrefPubMedGoogle Scholar
  • 24 WHO. Obesity – preventing and managing the global epidemic. Report of a WHO Consultation on obesity. WHO Techn Rep Ser 2000; 894: 1-253
    PubMedGoogle Scholar
  • 25 O`Rahilly S, Farooqi IS, Yeo GS, Challis BG. Minireview: human obesity lessons from monogenetic disorders. Endocrinology 2003; 144: 3757-3764
    CrossrefPubMedGoogle Scholar
  • 26 Nimptsch K, Pischon T. Adipositas und Krebs. Adipositas 2014; 8: 151-156
    PubMedGoogle Scholar
  • 27 Prugger C, Keil U. Entwicklung der Adipositas in Deutschland – Größenordnung, Determinanten und Perspektiven. Dtsch Med Wochenschr 2007; 132: 892-897
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Rahmouni K, Correia ML, Haynes WG, Mark AL. Obesity-associated hypertension: new insights into mechanism. Hypertension 2005; 45: 9-14
    CrossrefPubMedGoogle Scholar
  • 29 Rich-Edwards JA, Goldman MB, Willet WC et al. Adolescent body mass index and infertility caused by ovulatory dysfunction. Am J Obstet Gynecol 1994; 71: 171-177
    PubMedGoogle Scholar
  • 30 Schulte H, Cullen P, Assmann G. Obesity, mortality and cardiovascular disease in the Munster Heart Study (PROCAM). Atherosclerosis 1999; 144: 199-209
    CrossrefPubMedGoogle Scholar
  • 31 Shapira N. Women’s higher health risks in the obesogenic environment: a gender nutrition approach to metabolic dimorphism with predictive, preventive, and personalised medicine. EPMA J 2013; 4: 1-9
    CrossrefPubMedGoogle Scholar
  • 32 Slawik M, Beuschlein F. Genetik und Pathophysiologie der Adipositas. Internist 2006; 47: 120-129
    CrossrefPubMedGoogle Scholar
  • 33 Simon GE, Von Korff M et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiat 2006; 63: 824-830
    CrossrefPubMedGoogle Scholar
  • 34 Sullivan PW, Morrato EH, Ghushchyan V et al. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000–20002. Diabetes Care 2005; 28: 1599
    CrossrefPubMedGoogle Scholar
  • 35 Swinburn BA, Sacks G, Hall KD et al. The global obesity pandemic: shapes by global drivers and environments. Lancet 2011; 387: 804
    PubMedGoogle Scholar
  • 36 Wang Y, Chen X, Song Y et al. Association between obesity and kindney disease: a systematic review and meta-analysis. Kidney Int 2008; 73: 19-33
    CrossrefPubMedGoogle Scholar
  • 37 Weghofer A. Konzeption und Adipositas. Speculum – Zeitschrift für Gynäkologie und Geburtshilfe 2012; 30, 20-23
    PubMedGoogle Scholar
  • 38 Wilson PW, D’Agostino RB, Sullivan L et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002; 162: 1867-1872
    CrossrefPubMedGoogle Scholar
  • 39 Xu WL, Atti AR, Gatz M et al. Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology 2011; 76: 1568-1574
    CrossrefPubMedGoogle Scholar
  • 40 Yosipovitch G, DeVore A, Dawn A. Obesity and the skin: Skin physiology and skin manifestations of obesity. J Am Acad Dermatol 2007; 56: 901-916
    CrossrefPubMedGoogle Scholar
  • 41 Evidenzbasierte Leitlinie Prävention und Therapie der Adipositas. (S3-Leitlinie Version 2014) http://www.adipositas-gesellschaft.de/fileadmin/PDF/Leitlinien/050-001l_S3_Adipositas_Praevention_Therapie_2014-11.pdf
    PubMedGoogle Scholar