Chorionic Villus Sampling in Assisted Versus Spontaneous Conception Twins

Abstract

Purpose To compare the outcome of chorionic villus sampling (CVS) in twin pregnancies following assisted reproduction technology (ART) versus twins that have been conceived spontaneously.

Materials and Methods Retrospective analysis of dichorionic twin pregnancies that underwent CVS between 1986 and 2013 at our department which is a tertiary center for fetal medicine. 32 twin pregnancies after ART and 130 spontaneously conceived twin pregnancies, which underwent CVS, were analyzed.

Results No difference was observed in the pregnancy loss rate between the two groups (0 % in the ART group vs. 3 % in the spontaneous twins group). The rate of preterm delivery before 28 weeks was higher in the ART group (18.8 %) compared to the control group (1.6 %). The perinatal mortality rate was similar in the two groups.

Conclusion The pregnancy loss rate following CVS is similar in ART twins and in spontaneous twins. However, the risk of prematurity before 28 weeks is significantly higher in the ART group.

Zusammenfassung

Ziel Vergleich des Ausgangs der Chorionzottenbiopsie (CVS) bei Zwillingsschwangerschaften nach assistierter Reproduktionstechnik (ART) im Vergleich zu Zwillingen nach spontaner Konzeption.

Material und Methoden Retrospektive Analyse dichorialer Zwillingsschwangerschaften mit Chorionzottenbiopsie an unserer Abteilung, einem Tertiärzentrum für Pränatalmedizin von 1986 bis 2013. Analysiert wurden 32 Zwillingsschwangerschaften nach ART und 130 nach spontaner Konzeption, bei denen eine Chorionzottenbiopsie durchführt wurde.

Ergebnisse In Bezug auf die Verlustrate gab es keinen Unterschied zwischen beiden Gruppen (0 % in der ART-Gruppe vs. 5 % in der Gruppe mit spontaner Konzeption). Die Frühgeburtsrate vor der 28. Schwangerschaftswoche war in der ART-Gruppe (18,8 %) höher als in der Kontrollgruppe (1,6 %). Die perinatale Mortalität war in beiden Gruppen ähnlich hoch.

Schlussfolgerung Die Verlustrate nach CVS war bei Zwillingen nach ART und spontaner Konzeption ähnlich hoch. Allerdings ist das Risiko für Frühgeburtlichkeit vor der 28. Schwangerschaftswoche in der ART-Gruppe signifikant erhöht.

Key words

interventional procedures - ultrasound - obstetrics - twins - chorionic villus sampling

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