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J Neurol Surg B Skull Base 2022; 83(S 02): e40-e48
DOI: 10.1055/s-0041-1722930
Original Article

Clinical Analysis of En Bloc Resection for Advanced Temporal Bone Squamous Cell Carcinoma

Noritaka Komune 
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Daisuke Kuga
2   Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Satoshi Matsuo 
3   Department of Neurosurgery, Hamanomachi Hospital, Fukuoka, Japan
,
Masaru Miyazaki
4   Department of Otorhinolaryngology, Fukuoka University Hospital and School of Medicine, Fukuoka, Japan
,
Teppei Noda
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Kuniaki Sato
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Takahiro Hongo
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Kensuke Koike
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Ryutaro Uchi
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Ryunosuke Kogo
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Nana Akagi Tsuchihashi
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Shogo Masuda
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
,
Takashi Nakagawa
1   Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
› Author Affiliations Funding The part of this work was supported by JSPS KAKENHI grant number JP 18H02951 and 18K16895.
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Abstract

Objective En bloc and margin-negative surgical resection seems to offer the best prognosis for patients with temporal bone squamous cell carcinoma (TB-SCC). In this study, we summarize the outcomes of surgical cases of advanced TB-SCC (T3–T4) that were managed in two institutions, with an accompanying description of the surgical procedure that was utilized: modified subtotal temporal bone resection (STBR), which involves the en bloc removal of the temporal bone including or transecting the otic capsule.

Design This is a case series study with chart review.

Setting The study was conducted at two academic tertiary care medical centers.

Participants Chart information was collected for all patients who underwent surgical resection of advanced TB-SCC between July 1998 and February 2019. The resulting dataset contained 43 patients with advanced TB-SCC who underwent en bloc resection during the review period. Tumor staging followed the modified Pittsburgh classification. Disease-specific survival (DSS) rates were calculated according to the Kaplan–Meier method.

Main Outcome Measure This study shows disease-specific 5-year DSS rate.

Results The 5-year DSS rate of the cases who underwent en bloc resection was 79.7%. En bloc lateral temporal bone resection was employed in a total of 25 cases (DSS: 79.0%). En bloc modified STBR was utilized in 18 cases (DSS: 81.7%).

Conclusion En bloc margin-negative resection is a reliable treatment strategy for advanced TB-SCC. Modified STBR can be a treatment option for TB-SCC without marked posterior extension.

Keywords

subtotal temporal bone resection - squamous cell carcinoma - temporal bone - skull base


Publication History

Received: 20 July 2020

Accepted: 01 November 2020

Article published online:
12 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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