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J Neurol Surg B Skull Base 2022; 83(S 02): e291-e297
DOI: 10.1055/s-0041-1726128
Original Article

Clinical Efficacy of the Multilayered Skull Base Reconstruction Using In Situ Bone Flap in Endoscopic Endonasal Approach for Craniopharyngioma

Yuefei Zhou‡   *
1   Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
,
Yue Hei‡   *
1   Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
,
Jose M. Soto
2   Department of Neurosurgery, Baylor Scott and White Medical Center, Texas A&M University, College of Medicine, Temple, Texas, United States
,
Tao Jin
3   Department of Neurosurgery, The Center Hospital of Ankang City, Ankang, Shaanxi, China
,
Xiaofan Jiang
1   Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
,
Dongxia Feng
2   Department of Neurosurgery, Baylor Scott and White Medical Center, Texas A&M University, College of Medicine, Temple, Texas, United States
,
Weiping Liu
1   Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
,
Dakuan Gao
1   Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
› Author Affiliations Funding This research was supported by Natural Science Foundation of China (No. 81627806).
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Abstract

Objective The aim of the study is to summarize and analyze the efficacy of the multilayered skull base reconstruction using in situ bone flap in endoscopic endonasal approach (EEA) for craniopharyngiomas.

Methods A retrospective review of 65 patients who underwent resection of their histopathology confirmed craniopharyngiomas performed at a single institution. Based on the team's understanding and mastery of skull base reconstruction techniques, patients were divided into two groups according to the methods of reconstruction in two periods. First (March 2015 through August 2016), osseous reconstruction was not adopted and served as the control group (34 cases). Second (September 2016 through July 2019), in situ bone flap repair of the skull base (complete osseous reconstruction) served as observation group (31 cases). The length of hospitalization and nasal exudation, bed rest time of hospital discharge, the incidence of cerebrospinal fluid leaks, lumbar drainage, and intracranial/pulmonary infections were collected and compared.

Results Compared with the control group, patients in the observation group had obviously less lumbar drainage and CSF leakage (p < 0.05), but had no significant difference in cases of re-operation, meningitis, and pulmonary infection. At the meantime, cases of nasal exudation, bed rest, and hospitalization of the observation group were significantly reduced (p < 0.05) in the observation group.

Conclusion The multilayered reconstruction technique (especially using in situ bone flap, combined with vascularized pedicled nasoseptal flap) is a safe and effective method in achieving watertight closure after EEEA, and can significantly reduce the incidence of cerebrospinal fluid leaks, and facilitate rehabilitation in skull base reconstruction of craniopharyngiomas.

Keywords

extended endoscopic endonasal approach - craniopharyngioma - skull base reconstruction - multilayer - CSF leak

Authors' Contributions

D.G. contributed toward conception, design, and surgical operation. Y.Z., Y.H., and T.J. contributed toward data collection and analysis. Y.Z. and Y.H. drafted the article. J.X., D.G., and W.L. revised the article. D.G. approved the final version on behalf of all the authors. J.M.S. and D.F. contributed to language polishing. W.L. provided technical support and other help.


* These authors contributed equally to this work.




Publication History

Received: 21 April 2020

Accepted: 29 January 2021

Article published online:
31 May 2021

© 2021. Thieme. All rights reserved.

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