Introduction Unrecognized changes in hearing perception and their processing pose a serious barrier
to integration into our society. The threshold of hearing level from the averaged
measurements of brain stem potentials is visually determined in clinical practice.
Be in addition to the hearing, questions made determined wave morphology of hearing
function, so it is not possible to quantify this objective, to possess without concrete
references and evaluation algorithms.
Material / Methods: As part of hearing measurements on mice with genetically modified calcium channels
on the hair cells, single sweep ABR measurements on 30 mice of a control group of
normal hearing animals were performed. Based on a top-down process, the algorithm
was trained on the single sweeps to distinguish evoked responses from neuronal noise.
Furthermore, automatically acquired features from the singles weeps were compared
with each other via a cluster analysis.
Results The trained algorithm detects the hearing threshold very reliably with a maximum
deviation of +/- 5dB from the visual estimate. In addition, significant differences
in the wave growth function of "normal hearing" can be demonstrated. By means of the
cluster analysis, opposing effects in the single sweeps between immediately consecutive
wave forms of a sweep can be visualized. If a wave peak in the single sweep is pronounced,
the subsequent wave peak is less pronounced in the same single sweep and vice versa.
Poster-PDF
A-1162.pdf
BMBF Id Nr: 13GW0286A.
