Neuropediatrics 2021; 52(S 01): S1-S53
DOI: 10.1055/s-0041-1739644
Abstract Salzburg

Advantages of Botulinum Toxin A Treatment in Combination with Controlled Dynamic Stretching Orthotics for the Treatment of Contractures

Authors

  • Lieske van der Stam

    1   Center for Chronically Sick Children, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Markus Bülow

    1   Center for Chronically Sick Children, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Petra Bittigau

    1   Center for Chronically Sick Children, Charité-Universitätsmedizin Berlin, Berlin, Germany
    2   Department of Paediatric Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Angela M. Kaindl

    1   Center for Chronically Sick Children, Charité-Universitätsmedizin Berlin, Berlin, Germany
    2   Department of Paediatric Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany
    3   Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Berlin, Germany
 
 

    Background/Purpose: Spasticity appears in 80% of the children with cerebral palsy. Secondary to spasticity, contractures can occur. Botulinum toxin A (BTA) is used to treat spasticity, but not contractures. Therefore BTA is used in combination physical therapy (PT) and casting. Serial casting brings a great benefit in improving the passive range of motion (PROM), it does come with its disadvantages: skin irritations and pain are a common problem. But mostly, no active PT is possible while wearing the cast. With controlled dynamic stretching orthotics active PT is allowed during the most active period of BTA.

    We hypothesized that the combination of BTA with CDS orthotics will show greater results in terms of ankle joint PROM than BTA treatment only.

    Methods: Group A contained the treatment of calf muscles with BTA in combination with CDS orthotic. Group B contained the treatment of calf muscle with BTA only. Data of both treatment options were retrospectively compared with as primary endpoint PROM of the ankle joint.

    Results: Group A showed significant improvements at 1 (median 10° [p = 0.019]) and 3 months (median 10° [p = 0.016]) post-injections. This reduced back to a median 0° (p = 0.152) at 6 months post-injections. No significant changes were found in group B at 1 (median 5° [p = 0.340]), 3 (median 0° [p = 0.453]), or 6 (median −5° [p = 0.353]) months post-injections.

    Conclusion: The combinational therapy of BTA with CDS orthotics shows promising results in terms of PROM. This success could mean more comfortable treatment options in the future for children with calf muscle spasticity.


    Die Autoren geben an, dass kein Interessenkonflikt besteht.

    Publikationsverlauf

    Artikel online veröffentlicht:
    28. Oktober 2021

    © 2021. Thieme. All rights reserved.

    Georg Thieme Verlag KG
    Rüdigerstraße 14, 70469 Stuttgart, Germany