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Zeitschrift für Phytotherapie 2016; 37(02): 85-91
DOI: 10.1055/s-0042-104226
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© Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Sideritis scardica Griseb.

Der Griechische Bergtee
Klaus Peter Latté
Further Information

Publication History

Publication Date:
16 June 2016 (online)

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Zusammenfassung

Sideritis scardica Griseb. (Griechischer Bergtee) aus der Familie der Lamiaceae ist im Balkangebiet beheimatet. Teezubereitungen der Stängel mit Blüten von S. scardica werden dort seit Langem volksmedizinisch zur Behandlung von Lungenkrankheiten, Husten, Erkältung, Grippe und gastrointestinalen Beschwerden eingesetzt. Moderne In-vitro- und In-vivo-Methoden liefern eine Erklärung für die traditionellen Anwendungsgebiete. Phytochemische Untersuchungen führten zur Identifizierung eines breiten Spektrums an phenolischen Verbindungen, insbesondere von Flavonen, sowie von Diterpenen und einem ätherischem ml. In den letzten Jahren sind weitere Studien zur potenziellen Anwendung von S. scardica bei neurologischen Störungen und neurodegenerativen Erkrankungen durchgeführt worden. Bislang liegen keine klinischen Studien für die Anwendung von S. scardica vor.

Summary

Sideritis scardica Griseb.: The Greek mountain tea

Sideritis scardica Griseb. (Greek mountain tea) belongs to the Lamiaceae family and is endemic to the Balkan Peninsula. Tea preparations of the apices of the stems including the leaves and flowers of S. scardica have been highly valued in traditional medicine for a long time amongst others for the treatment of lung diseases, cough, cold, influenza and gastrointestinal disorders. Application of modern in vitro and in vivo methods gives an explanation for these traditional indications. Phytochemical studies revealed the presence of a broad spectrum of phenolic compounds, especially flavones, and also of diterpenes and an essential oil. Within the last few years, some further studies were performed in order to evaluate the application of S. scardica for the treatment of neurological disorders and neurodegenerative diseases. However, S. scardica and its extracts have not been studied in clinical trials so far.

Schlüsselwörter

Sideritis scardica - Lamiaceae - Herba Sideritidis scardicae - Griechischer Bergtee - Flavonoide - traditionelle Anwendung

Keywords

Sideritis scardica - Lamiaceae - Herba Sideritidis scardicae - Greek mountain tea - flavonoids - traditional use
 

  • Literatur

  • 1 Baser KH, Kirimer N. Essential oil of Sideritis scardica Griseb. subsp. scardica . J Essent Oil Res 1997; 9: 205-207
    CrossrefPubMedGoogle Scholar
  • 2 Bojovic D, Jaskovic S, Potpara Z, Tadic V. Summary of the phytochemical research performed to date on Sideritis species. Serb J Exp Clin Res 2011; 12: 109-122
    PubMedGoogle Scholar
  • 3 Danesi F, Saha S, Kroon PA et al. Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. J Sci Food Agric 2013; 93: 3558-3564
    CrossrefPubMedGoogle Scholar
  • 4 Dimpfel W. Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat. J Ethnopharmacol 2013; 149: 583-589
    CrossrefPubMedGoogle Scholar
  • 5 EMA. European Union herbal monograph on Sideritis scardica Griseb.; Sideritis clandestina (Bory & Chaub.) Hayek; Sideritis raeseri Boiss. & Heldr.; Sideritis syriaca L., herba. Draft. EMA/HMPC/39453/2015 vom 07.07.2015
    PubMedGoogle Scholar
  • 6 EMA. Assessment report on Sideritis scardica Griseb.; Sideritis clandestina (Bory & Chaub.) Hayek; Sideritis raeseri Boiss. & Heldr.; Sideritis syriaca L., herba. Draft. EMA/HMPC/39455/2015 vom 07.07.2015
    PubMedGoogle Scholar
  • 7 Evstatieva LN, Koleva I. Cultivation of Sideritis scardica Griseb. In: Proceedings of the First Conference of Medicinal and Aromatic Plants of Southeast Europe. Arandelovac: 2000: 189-195
    Google Scholar
  • 8 Feistel B, Walbroel B, Pahnke J. Extract preparation from Sideritis scardica enhances memorizing skills of mice in Morris water maze. Planta Med 2013; 79: BP79
    PubMedGoogle Scholar
  • 9 Fraga BM. Phytochemistry and chemotaxonomy of Sideritis species from the Mediterranean region. Phytochemistry 2012; 76: 7-24
    CrossrefPubMedGoogle Scholar
  • 10 Giuliani C, Maleci Bini L. Insight into the structure and chemistry of glandular trichomes of Labiatae, with emphasis on subfamily Laminoideae. Plant Syst Evol 2008; 276: 199-208
    CrossrefPubMedGoogle Scholar
  • 11 González- Bu, Carretero ME, Gómez-Serranillos MP. Sideritis spp.: Uses, chemical composition and pharmacological activities - A review. J Ethnopharmacol 2011; 135: 209-225
    CrossrefPubMedGoogle Scholar
  • 12 González-Burgos E, Carretero ME, Gómez-Serranillos MP. In vitro permeability study of CNS-active diterpenes from Sideritis spp. using cellular models of blood-brain barrier. Planta Med 2013; 79: 1545-1551
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Grisebach AHR. Spicilegium florae rumelicae et bithynicae exhibens synopsin plantarum, Bd. 2. Brunsvigae; 1844: 141
    Google Scholar
  • 14 Hager Enzyklopädie der Arzneistoffe. 6. Aufl. Stuttgart: Wissenschaftl. Verlagsges.; 2007
    PubMedGoogle Scholar
  • 15 Harnisch G. Griechisches Eisenkraut. 2. Aufl. Kirchzarten: VAK Verlags GmbH; 2013
    Google Scholar
  • 16 Heiner F, Feistel B, Wink M. Sideritis scardica extracts inhibit the aggregation of α-synuclein and β-amyloid peptides in Caenorhabditis elegans used as a model for neurodegenerative diseases. Planta Med 2015; 81: PW_127
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Ibraliu A, Trendafilova AB, Andelković BD et al. Comparative study of Balkan S ideritis species from Albania, Bulgaria and Macedonia. Eur J Med Plants 2015; 5: 328-340
    PubMedGoogle Scholar
  • 18 Jeremic I, Tadic V, Isakovic A et al. The mechanisms of in vitro cytotoxicity of mountain tea, Sideritis scardica, against the C6 glioma cell line. Planta Med 2013; 79: 1516-1524
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Jeremic I, Petrovic D, Zivkovic M et al. Sideritis scardica extract prevents bone loss in ovariectomized rats. Ann Rheum Dis 2015; 74: 921
    PubMedGoogle Scholar
  • 20 Knörle R. Extracts of Sideritis scardica as triple monoamine reuptake inhibitors. J Neural Transm 2012; 119: 1477-1482
    CrossrefPubMedGoogle Scholar
  • 21 Kostadinova E, Nikolova D, Alipieva K et al. Chemical constituents of the essential oils of Sideritis scardica Griseb. and Sideritis raeseri Boiss and Heldr. from Bulgaria and Macedonia. Nat Prod Res 2007; 21: 819-823
    CrossrefPubMedGoogle Scholar
  • 22 Lim TK. Sideritis scardica . In: Lim TK, ed. Edible and non medicinal plants. Dordrecht: Springer Science; 2014: 207-214
    CrossrefGoogle Scholar
  • 23 Papanikolaou K, Kokkini S. A taxonomic revision of Sideritis L. section Empedoclia (Rafin.) Bentham (Labiatae) in Greece. In: Margis N, Koedam A, Vokou D, ed. Aromatic plants: Basic and applied aspects. Den Haag, Boston, London: Martinus Nijhoff Publishers; 1982: 114-117
    CrossrefGoogle Scholar
  • 24 Petreska J, Stefova M, Ferreres F et al. Potential bioactive phenolics of Macedonian Sideritis species used for medicinal “Mountain Tea”. Food Chem 2011; 125: 13-20
    CrossrefPubMedGoogle Scholar
  • 25 Petreska J, Stefova M, Ferreres F et al. Dietary burden of phenolics per serving of “Mountain Tea” (Sideritis) from Macedonia and correlation to antioxidant activity. Nat Prod Commun 2011; 6: 1305-1314
    PubMedGoogle Scholar
  • 26 Petreska St, Stefova M. Evaluation of the ion trap MS performance for quantification of flavonoids and comparison to UV detection. J Mass Spectrom 2012; 47: 1395-1406
    CrossrefPubMedGoogle Scholar
  • 27 Petreska St, Bagashovska D, Stefova M. Characterization of urinary bioactive phenolic metabolites excreted after consumption of a cup of mountain tea (Sideritis scardica) using liquid chromatography-tandem mass spectrometry. Maced J Chem Chem Eng 2012; 31: 229-243
    PubMedGoogle Scholar
  • 28 Petreska St, Stefova M, Stefkov G et al. Chemotaxonomic contribution to the Sideritis species dilemma on the Balkans. Biochem Syst Ecol 2015; 61: 477-487
    CrossrefPubMedGoogle Scholar
  • 29 Piozzi F, Bruno M, Rosselli AM, Maggio A. The diterpenoids from the genus Sideritis . In: Atta-ur-Rahman ed. Studies in natural products chemistry. Vol. 33 Amsterdam: Elsevier; 2006: 493-540
    Google Scholar
  • 30 Qazimi B, Karapandzova M, Stefkov G, Kulevanova S. Chemical composition of ultrasonic-assisted n-hexane extracts of Sideritis scardica Griseb. and Sideritis raeseri Boiss & Heldr. (Lamiaceae) from Macedonia and Albania. Maced Pharm Bull 2010; 56: 45-56
    PubMedGoogle Scholar
  • 31 Qazimi B, Stefkov G, Karapandzova M et al. Aroma compounds of mountain tea (Sideritis scardica and S. raeseri) from Western Balkan. Nat Prod Commun 2014; 9: 1369-1372
    PubMedGoogle Scholar
  • 32 Shtereva LA, Vassilevska-Ivanova RD, Kraptchev BV. In vitro cultures for micropropagation, mass multiplication and preservation of an endangered medicinal plant Sideritis scardica Griseb. Bot Serb 2015; 39: 111-120
    PubMedGoogle Scholar
  • 33 Tadic VM, Jeremic I, Dobric S et al. Anti-inflammatory, gastroprotective, and cytotoxic effects of Sideritis scardica extracts. Planta Med 2012; 78: 415-427
    Article in Thieme ConnectPubMedGoogle Scholar
  • 34 Tadić V, Bojović D, Arsić I et al. Chemical and antimicrobial evaluation of supercritical and conventional Sideritis scardica Griseb., Lamiaceae extracts. Molecules 2012; 17: 2683-2703
    CrossrefPubMedGoogle Scholar
  • 35 Todorova M, Trendafilova A, Evstatieva L, Antonova D. Volatile components in Sideritis scardica Griseb. cultivar. Compt Rend Acad Bulg Sci 2013; 66: 507-512
    PubMedGoogle Scholar
  • 36 Todorova M, Trendafilova A. Sideritis scardica Griseb., an endemic species of Balkan peninsula: Traditional uses, cultivation, chemical composition, biological activity. J Ethnopharmacol 2014; 152: 256-265
    CrossrefPubMedGoogle Scholar
  • 37 Topcu G, Kusman T. Lamiaceae family plants as a potential anticholinesterase source in the treatment of Alzheimer’s Disease. Bezmialem Science 2014; 1: 1-25
    PubMedGoogle Scholar
  • 38 Trendafilova AB, Todorova MN, Evstatieva LN, Antonova DV. Variability in the essential-oil composition of Sideritis scardica Griseb. from native Bulgarian populations. Chem Biodiv 2013; 10: 484-492
    CrossrefPubMedGoogle Scholar
  • 39 Tunalier Z, Kosar M, Ozturk N et al. Antioxidant properties and phenolic composition of Sideritis species. Chem Nat Compds 2004; 40: 206-210
    CrossrefPubMedGoogle Scholar
  • 40 Venturella P, Bellino A. Isolation and partial synthesis of ent-18-acetoxykaur-16-ene-3β,7α,15β-triol from Sideritis scardica . Phytochemistry 1979; 18: 1571-1572
    CrossrefPubMedGoogle Scholar
  • 41 Yaneva I, Balabanski V. History of the uses of Pirin mountain tea (Sideritis scardica Griseb) in Bulgaria. Bulg J Public Health 2013; 5: 48-57
    PubMedGoogle Scholar