Gerinnungsstörungen im Kindesalter

Kernaussagen

• Eine schwere angeborene Blutungsneigung manifestiert in der Regel im ersten Lebensjahr. Zu den typischen Symptomen zählen u. a. intrakranielle Blutung, Hämatome nach Bagatellverletzungen, flächenhafte Petechien, Purpura, Ekchymosen oder auch Gelenkblutungen.

• Vor der Labordiagnostik sind eine körperliche Untersuchung und insbesondere das Erheben der Eigen- und Familienanamnese wichtig.

• Laborergebnisse muss man bei Kindern anhand altersentsprechender Referenzwerte interpretieren, da sich diese teils erheblich von den Werten für Erwachsene unterscheiden.

• Eine spezifische Therapie einer Gerinnungsstörung im Kindesalter ist erst nach Abschluss der umfassenden klinischen und laborchemischen Diagnostik möglich.

• Diagnostik und Therapie einer angeborenen Blutgerinnungsstörung erfordern eine fachübergreifende Zusammenarbeit zwischen Neonatologe, Pädiater, Hämostaseologe und Labormediziner.

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