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Aktuelle Rheumatologie 2017; 42(04): 316-322
DOI: 10.1055/s-0042-112362
Übersichtsarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Mischkollagenose, Overlap-Kollagenose und undifferenzierte Kollagenose

Mixed Connective Tissue Disease, Overlap Connective Tissue Disease and Undifferentiated Connective Tissue Disease
W. Merkt
1   Medizinische Klinik V, Sektion Rheumatologie, Universitätsklinikum Heidelberg
,
H.-M. Lorenz
1   Medizinische Klinik V, Sektion Rheumatologie, Universitätsklinikum Heidelberg
2   ACURA-Rheumazentrum Baden-Baden
,
C. Fiehn
2   ACURA-Rheumazentrum Baden-Baden
› Author Affiliations
Further Information

Publication History

Publication Date:
30 August 2017 (online)

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Zusammenfassung

Neben den klassifizierbaren Kollagenosen gibt es eine Gruppe ehemals unklassifizierbarer Erkrankungen, die sich klinische und serologische Gemeinsamkeiten mit den klassifizierbaren Kollagenosen teilen. In den letzten Jahren wurden diese „unklassifizierbaren“ Kollagenosen, nämlich die Mischkollagenose, die Overlap-Kollagenose und die undifferenzierte Kollagenose epidemiologisch und teilweise auch pathogenetisch aufgearbeitet. Wir umreißen in diesem Artikel aktuelle Erkenntnisse in der Pathogenese, die neuere Literatur zu Klassifikation und Diagnose sowie die noch geringe Evidenz zu therapeutischen Möglichkeiten.

Abstract

Next to the classifiable connective tissue diseases, there is a group of formerly not classifiable diseases that share clinical and serological features with the classifiable connective tissue diseases. During the course of the last years, these ‚unclassifiable‘ connective tissue diseases, namely mixed, overlap and undifferentiated connective tissue disease, were epidemiologically and, in part, pathogenetically investigated. We here summarize the current insights in pathogenesis, the novel literature on classification and diagnosis as well as the still limited evidences about therapeutic measures.

Schlüsselwörter

Mischkollagenose - Overlap-Kollagenose - undifferenzierte Kollagenose

Key words

mixed connective tissue disease - overlap connective tissue disease - undifferentiated connective tissue disease
 

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