Nuklearmedizin 2022; 61(02): 181
DOI: 10.1055/s-0042-1746069
Abstracts | NuklearMedizin 2022
WIS-Vortrag
Onkologie – Bildgebung II

Diagnostic accuracy of dual-phase F-18-FDG-PET/CT using time-of-flight reconstruction algorithm in staging of patients with suspected pancreatic cancer

S. Stanzel
1   Med.Universität Graz, Univ.-Klinik für Radiologie, Klin. Abteilung für Nuklearmedizin, Graz
,
T. Nazerani Hooshmand
1   Med.Universität Graz, Univ.-Klinik für Radiologie, Klin. Abteilung für Nuklearmedizin, Graz
,
R.M. Aigner
1   Med.Universität Graz, Univ.-Klinik für Radiologie, Klin. Abteilung für Nuklearmedizin, Graz
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    Ziel/Aim The aim of this study was to evaluate the impact of TOF on image quality, lesion detection rate, and SUVmax in dual-phase (DP) F-18-FDG-PET/CT in staging of patients with suspected pancreatic cancer.

    Methodik/Methods One hundred and twenty patients with suspected pancreatic cancer were included in this prospective study. Each patient underwent DP F-18-FDG-PET/CT including a diagnostic CT of the upper abdomen. PET/CT imaging was performed 30 and 90 min p.i. A total of 204 lesions were assessed by one board-certified nuclear medicine physician and a third-year resident. SUVmax and lesion volume of pancreatic lesions, lymph node metastases, organ metastases, and other benign lesions were compared between TOF and non-TOF. All lesions were either confirmed histopathologically or with follow-ups. Lesion demarcation of pancreatic and all other lesions was rated according to a 6-point Likert-type scale. Interrater agreement was assessed.

    Ergebnisse/Results Eighty-six pancreatic lesions were malignant and 34 benign. Forty-four additional lesions were detected using TOF alone (SUVmax, 5.0 [2.5]; V, 2.9 cm³ [1.4]). Of these two were pancreatic primary tumours, 32 metastases and 10 lesions were benign. Lesion demarcation of pancreatic and all other lesions was excellent (pancreatic lesions, non-TOF, 3.2.; TOF, 1.5.; P<0.0001; all other lesions, non-TOF, 2.7; TOF; 1.2 P<0.0001) in reconstructed TOF images. SUVmax was significantly increased in TOF images (SUVmax non-TOF, 9.0 [8.2]; TOF, 10.0 [8.5]; P<0.0001), whereas V did not show significant differences (V non-TOF, 13.8 [23.6] cm3; TOF, 16.3 [33.2] cm3; P=0.07). Interrater agreement was good for combined ratings for pancreatic lesions and moderate for combined ratings for all lesions.

    Schlussfolgerungen/Conclusions Application of TOF seems to be of additional value in detecting pancreatic and small metastatic lesions in patients with suspected pancreatic cancer, which may have an impact on further treatment.


     

    Publication History

    Article published online:
    14 April 2022

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