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DOI: 10.1055/s-0042-1746863
Granulomatosis With Polyangiitis, Primarily Presented by Otological Symptoms: A Case Report and Literature Review
Introduction
Granulomatosis with polyangiitis (GPA) is a rare, multisystemic, granulomatous vasculitis which is highly associated with anti-neutrophil cytoplasmic antibodies (cANCA). It is characterized by necrotizing granulomas, usually affecting the small blood vessels of airways and kidneys, but other organs, including eyes, joints and skin can also be involved.
Case Report
We report a case of a 68-year-old female, who initially presented with various refractory otologic symptoms followed by delayed sinonasal and arthritic involvement. Autoantibody tests demonstrated a positive proteinase-3 (PR-3) cANCA titers at 126.0 IU/ mL (normal < 10.0) and nasal biopsy confirmed the diagnosis of GPA.
Conclusion
A primary, solitary otological manifestation of granulomatosis with polyangiitis is uncommon; therefore, it should be considered in the differential diagnosis when symptoms progress rapidly or do not improve despite appropriate management.
Conflict of Interest
The author declares that there is no conflict of interest.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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