Klin Padiatr 2022; 234(05): 328
DOI: 10.1055/s-0042-1754470
Abstracts
Poster
Poster Walk 1: Asthma, Bronchoskopie

Application and external validation of the Asthma Severity Scoring System in children and adults

L Riemann
1   Hannover Medical School, Department of Paediatric Pneumology, Allergology and Neonatology, Hannover, Germany
2   Else-Kröner Fresenius Stiftung, Forschungskolleg TITUS, Hannover, Germany
,
R Grychtol
1   Hannover Medical School, Department of Paediatric Pneumology, Allergology and Neonatology, Hannover, Germany
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
,
S Gaedcke
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
,
B Liu
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
,
D DeLuca
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
,
R Förster
4   Hannover Medical School, Institute of Immunology, Hannover, Germany
,
D Thiele
5   Institute of Medical Biometry and Statistics (IMBS), University Medical Center Schleswig-Holstein, Lübeck, Germany
6   Airway Research Center North (ARCN), Lübeck, Germany
,
N Maison
7   Institute for Asthma- and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany
8   Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany
9   Comprehensive Pneumology Center – Munich (CPC-M; Member of German Center for Lung Research (DZL), Munich, Germany
,
N Jakobs
10   Section for Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany
6   Airway Research Center North (ARCN), Lübeck, Germany
,
T Bahmer
6   Airway Research Center North (ARCN), Lübeck, Germany
11   University Hospital Schleswig-Holstein, Campus Kiel, Internal Medicine I, Kiel, Germany
12   LungenClinic Grosshansdorf, Grosshansdorf, Germany
,
M Meyer
13   Faculty of Medicine, University Children's Hospital, University of Cologne, Cologne, Germany
,
S Foth
14   Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Giessen/Marburg, Germany
15   University Children’s Hospital Marburg, University of Marburg, Marburg, Germany
,
S Weber
14   Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Giessen/Marburg, Germany
15   University Children’s Hospital Marburg, University of Marburg, Marburg, Germany
,
E Rietschel
13   Faculty of Medicine, University Children's Hospital, University of Cologne, Cologne, Germany
,
KF Rabe
6   Airway Research Center North (ARCN), Lübeck, Germany
12   LungenClinic Grosshansdorf, Grosshansdorf, Germany
,
MV Kopp
10   Section for Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany
6   Airway Research Center North (ARCN), Lübeck, Germany
16   Department of Pediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland
,
E von Mutius
7   Institute for Asthma- and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany
8   Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany
9   Comprehensive Pneumology Center – Munich (CPC-M; Member of German Center for Lung Research (DZL), Munich, Germany
,
A-M Dittrich
1   Hannover Medical School, Department of Paediatric Pneumology, Allergology and Neonatology, Hannover, Germany
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
,
G Hansen
1   Hannover Medical School, Department of Paediatric Pneumology, Allergology and Neonatology, Hannover, Germany
3   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany
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    Introduction The Asthma Severity Scoring System (ASSESS) is a new tool to assess asthma severity in children ³ 12 years and adults. It incorporates data about asthma control, lung function, exacerbations and asthma medication. In this study, we sought to validate the ASSESS score in the All Age Asthma Cohort (ALLIANCE) and explore its usability in children < 12 years.

    Methods Scale properties, responsiveness, and known-group validity were assessed in pediatric and adult asthma patients recruited to the multicenter ALLIANCE cohort.

    Results In total, 247 pediatric (mean age 11 years, IQR: 8-13 years) and 206 adult asthma patients (mean age 52 years, IQR: 43-63 years) were included in this study. Internal consistency of the ASSESS score was similar to the original application in the Severe Asthma Research Program (Cronbach’s a 0.48 in all children and 0.73 in adults). Test-retest reliability using Interclass Correlation Coefficient (ICC) visits was moderate (0.65 in children and 0.64 in adults). Mean ASSESS scores were significantly worse (p < 0.05) in patients with poor asthma control, with ³ 1 exacerbations, ³1 hospitalizations, ³ 2 wheeze episodes and increased salbutamol use demonstrating good known-group validity. Children < 12 years showed equally good known-group validity, however, Cronbach’s a and ICC were lower in children < 12 years compared to children ³ 12 years (Cronbach’s a of 0.35 and 0.59, respectively and ICC 0.47 and 0.77, respectively).

    Conclusion Previously reported ASSESS score characteristics were verified in asthma patients ³ 12 years in the ALLIANCE cohort. In children 6-11 years score properties were inferior while construct validity was good, indicating a need for further evaluation or adaptation of the ASSESS score in this age group.


     

    Conflict of Interest 

    No

    Publikationsverlauf

    Artikel online veröffentlicht:
    21. September 2022

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