Abstract
The purpose of this retrospective study was to investigate the effects of a single
dose of aminophylline on urine output and fluid balance in children admitted to the
cardiac intensive care unit. A retrospective study was performed to compare variables
of interest before and 24 hours after aminophylline administration in children under
the age of 18 years who were admitted to the cardiac intensive care unit at our institution
from January 2011 onwards. Variables of interest included age, weight, aminophylline
dose, concurrently administered diuretics, specific hemodynamic parameters, and blood
urea nitrogen and creatinine levels. Variables such as urine output and fluid balance
were measured through a binary endpoint. Data were compared in a paired fashion and
continuous variables were compared through paired t-tests. Analyses were conducted using SPSS Version 23.0. A total of 14 patients were
included in the study. There was no significant change in hemodynamic parameters or
creatinine levels before and after intravenous aminophylline administration of 5 mg/kg.
There was a significant difference in urine output, fluid balance, and blood urea
nitrogen levels from the baseline value. Concurrent usage of diuretics did not show
significant association with a difference in urine output or fluid balance from baseline.
No significant adverse reactions were noted 24 hours after administration of aminophylline.
Use of aminophylline dosed at 5 mg/kg is safe and leads to improvement in urine output
and fluid balance without negatively impacting systemic oxygen delivery or renal filtration
function.
Keywords
pediatric - cardiac intensive care - xanthine - aminophylline
