Klin Padiatr 2017; 229(03): 147-167
DOI: 10.1055/s-0043-103086
Diagnostic and Treatment Recommendation
© Georg Thieme Verlag KG Stuttgart · New York

2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

2017 GPOH Empfehlungen für Diagnostik und Therapie von Patienten mit neuroblastischen Tumoren

Authors

  • Thorsten Simon

    1   Department of Pediatric Oncology and Hematology, University Hospital, University of Cologne
  • Barbara Hero

    1   Department of Pediatric Oncology and Hematology, University Hospital, University of Cologne
  • Johannes H. Schulte

    2   Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin
  • Hedwig Deubzer

    2   Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin
  • Patrick Hundsdoerfer

    2   Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin
  • Dietrich von Schweinitz

    3   Department of Pediatric Surgery, Dr. von Hauner’sches Kinderspital, LMU Munich
  • Jörg Fuchs

    4   Department of Pediatric Surgery and Pediatric Urology, University Hospital Tübingen
  • Matthias Schmidt

    5   Department of Nuclear Medicine, University Hospital, University of Cologne
  • Vikas Prasad

    6   Department of Nuclear Medicine, Charité University Hospital Berlin
  • Barbara Krug

    7   Department of Radiology, University Hospital, University of Cologne
  • Beate Timmermann

    8   Clinic for Particle Therapy, Westdeutsches Protonentherapiezentrum, University Hospital Essen
  • Ivo Leuschner

    9   Kiel Pediatric Tumor Registry, Dept. for Pediatric Pathology, University Hospital of Schleswig-Holstein, Campus Kiel
  • Matthias Fischer

    10   Department of Experimental Pediatric Oncology, University Hospital, University of Cologne
  • Thorsten Langer

    11   Pediatric Oncology and Hematology, University Hospital Schleswig-Holstein, Campus Lübeck
  • Kathy Astrahantseff

    2   Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin
  • Frank Berthold

    1   Department of Pediatric Oncology and Hematology, University Hospital, University of Cologne
  • Holger Lode

    12   Department of Pediatrics and Pediatric Oncology and Hematology, University Medicine Greifswald
  • Angelika Eggert

    2   Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin
Further Information

Publication History

Publication Date:
30 May 2017 (online)

Abstract

The clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.