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Exp Clin Endocrinol Diabetes 2017; 125(08): 547-553
DOI: 10.1055/s-0043-109099
Article
© Georg Thieme Verlag KG Stuttgart · New York

RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction

Danyan Chen
1   Departments of Endocrinology & Nephrology, the Chongqing General Hospital, Chongqing, China
,
Xiaolong Huang
2   Departments of Neurosurgery, No. 324 Hospital of PLA, Chongqing, China
,
Song Lu
1   Departments of Endocrinology & Nephrology, the Chongqing General Hospital, Chongqing, China
,
Huacong Deng
3   Departments of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Hua Gan
4   Departments of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Xiaogang Du
4   Departments of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Tang Weixue
5   Departments of Pathophysiology, Basic Medical College, Chongqing Medical University, Chongqing, China
› Author Affiliations
Further Information

Publication History

received 17 October 2016
revised 12 April 2017

accepted 18 April 2017

Publication Date:
13 July 2017 (online)

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Abstract

Aim To investigate the RBP4/Lp-PLA2/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI).

Methods One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA2 and Netrin-1 were determined by Western Blot.

Results Compared with NSCI group, the cognitive function of patients in SCI group was impaired, the concentrations of RBP4 and the expressions of Lp-PLA2 and Netrin-1 increased (P<0.05). RBP4 concentrations were positively correlated with the cognitive dysfunction of SCI patients. Moreover, there existed a regression correlation between them.

Conclusion RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with SCI and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.

Key Words

diabetic nephropathy - silent cerebral infarction - function impairment - RBP4/Lp-PLA2/Netrin-1
 

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