Int J Sports Med 2017; 38(11): 833-841
DOI: 10.1055/s-0043-112501
Orthopedics & Biomechanics
© Georg Thieme Verlag KG Stuttgart · New York

Intramuscular Perfusion Response in Delayed Onset Muscle Soreness (DOMS): A Quantitative Analysis with Contrast-Enhanced Ultrasound (CEUS)

Marion Kellermann
1   Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Division of Orthopedic Rheumatology, Department of Orthopedic Surgery, Erlangen, Germany
,
Rafael Heiss
2   University Hospital Erlangen, Department of Radiology, Erlangen, Germany
,
Bernd Swoboda
1   Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Division of Orthopedic Rheumatology, Department of Orthopedic Surgery, Erlangen, Germany
,
Kolja Gelse
3   University Hospital Erlangen, Department of Orthopedic Trauma Surgery, Erlangen, Germany
,
Jürgen Freiwald
4   University of Wuppertal, Movement Science, Wuppertal, Germany
,
Casper Grim
5   Klinikum Osnabruck GmbH, Department of Trauma and Orthopedic Surgery, Osnabrück, Germany
,
Armin Nagel
2   University Hospital Erlangen, Department of Radiology, Erlangen, Germany
,
Michael Uder
2   University Hospital Erlangen, Department of Radiology, Erlangen, Germany
,
Dane Wildner
6   Friedrich-Alexander-University Erlangen-Nürnberg, Department of Internal Medicine 1, Erlangen, Germany
,
Thilo Hotfiel
1   Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Division of Orthopedic Rheumatology, Department of Orthopedic Surgery, Erlangen, Germany
› Author Affiliations
Further Information

Publication History



accepted after revision 19 May 2017

Publication Date:
10 August 2017 (online)

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Abstract

The purpose of this study was to analyse intramuscular perfusion response in ultrastructural muscle lesions, by applying contrast-enhanced ultrasound (CEUS) to a delayed onset muscle soreness (DOMS) model. Results of this analysis were compared to high-resolution 3 Tesla MRI T2-weighted sequences. 14 healthy participants were recruited. Average perfusion parameters, represented as Peak enhancement (contrast agent inflow) and wash-in area under curve (WiAUC) of the gastrocnemius (GM) and soleus muscle (SM) were assessed before (baseline) and 60 h after inducing DOMS by eccentric exercise. Additionally, conventional ultrasound, high-resolution 3T MRI, creatine kinase level, range of motion (ROM) of the ankle joint, calf circumference and muscle soreness data were collected. Perfusion quantification revealed a statistically significant increase of intramuscular perfusion, corresponding to an increase in peak enhancement of 129.6% (p=0.0031) and in WiAUC of 115.2% (p=0.0107) in the gastrocnemius muscle at post-intervention. At follow-up, the MRI investigations showed intramuscular oedema for GM in all participants corresponding to a significant rise in T2 signal intensity (p=0.001) and in T2 time value (p=0.005). CEUS seems to be able to detect intramuscular perfusion changes and therefore may contribute to gaining deeper insight into the histopathology, inflammatory reactions and regeneration processes of ultrastructural muscle lesions.