S3-Leitlinie Prophylaxe der venösen Thromboembolie

Neue Erkenntnisse und neu zugelassene Präparate zur Prophylaxe der venösen Thromboembolie mündeten in eine aktualisierte S3-Leitlinie. Diese berücksichtigt unter anderem therapierelevante Risikofaktoren, empfehlenswerte und sich ggf. ergänzende Prophylaxemethoden, die erforderliche Aufklärung sowie mögliche Komplikationen und deren Management.

Schlüsselwörter

Venöse Thromboembolie - tiefe Venenthrombose - Prophylaxe - Risikofaktoren - heparininduzierte Thrombozytopenie (HIT)

• Literatur

• 1 Encke A, Haas S, Koop I. et al. S3-Leitlinie Prophylaxe der venösen Thromboembolie. Im Internet: http://www.awmf.org/leitlinien/detail/ll/003-001.html Stand: 06.11.2016
• 2 Guyatt GH, Akl EA, Crowther M. et al. Executive summary: Antithrombotic Therapy and Prevention of Thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (9th Edition). Chest 2012; 141 (Suppl. 02) S7-S47
• 3 Stein PD, Beemath A, Olson RE. Trends in the incidence of pulmonary embolism and deep venous thrombosis in hospitalized patients. Am J Cardiol 2005; 95: 1525-1526
• 4 Samama CM, Albaladejo P, Benhamou D. et al. Venous thromboembolism prevention in surgery and obstetrics: clinical practice guidelines. Eur J Anaesthesiol 2006; 23: 95-116
• 5 Bergqvist D. Update on in hospital venous thromboembolism prophylaxis. Eur J Vasc Endovasc Surg 2007; 33: 343-350
• 6 Langlois NJ, Wells PS. Risk for venous thromboembolism in relatives of symptomatic probands with thrombophilia: a systematic review. Thromb Haemost 2003; 90: 17-26
• 7 DeStefano V, Rossi E, Za T. et al. Prophylaxis and treatment of venous thromboembolism in individuals with inherited thrombophilia. Semin Thromb Hemost 2006; 32: 767-780
• 8 Wu O, Robertson L, Twaddle S. et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess 2006; 10: 1-110
• 9 Wahl WL, Brandt MM, Ahrns K. et al. The utility of D-dimer levels in screening for thromboembolic complications in burn patients. J Burn Care Rehabil 2002; 23: 439-443
• 10 Cofrancesco E, Cortellaro M, Corradi A. et al. Coagulation activation markers in the prediction of venous thrombosis after elective hip surgery. Thromb Haemost 1997; 77: 267-269
• 11 Ginsberg JS, Brill-Edwards P, Panju A. et al. Pre-operative plasma levels of thrombin-antithrombin III complexes correlate with the development of venous thrombosis after major hip or knee surgery. Thromb Haemost 1995; 74: 602-605
• 12 Geerts WH, Bergqvist D, Pineo GF. et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (Suppl. 06) S381-S453
• 13 Zacharoulis D, Kakkar AK. Venous thromboembolism in laparoscopic surgery. Curr Opin Pulm Med 2003; 9: 356-361
• 14 Bhandari M, Whang W, Kuo JC. et al. The risk of false-positive results in orthopaedic surgical trials. Clin Orthop Relat Res 2003; (413) 63-69
• 15 Schippinger G, Wirnsberger GH, Obernosterer A. et al. Thromboembolic complications after arthroscopic knee surgery. Incidence and risk factors in 101 patients. Acta Orthop Scand 1998; 69: 144-146
• 16 Ilahi OA, Reddy J, Ahmad I. Deep venous thrombosis after knee arthroscopy: a meta-analysis. Arthroscopy 2005; 21: 727-730
• 17 Roderick P, Ferris G, Wilson K. et al. Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis. Health Technol Assess 2005; 9: 1-94
• 18 Wille-Jørgensen P, Rasmussen MS, Andersen BR. et al. Heparins and mechanical methods for thromboprophylaxis in colorectal surgery. Cochrane Database Syst Rev 2001; (03) CD001217
• 19 Eppsteiner RW, Shin JJ, Johnson J et al. Mechanical compression versus subcutaneous heparin therapy in postoperative and posttrauma patients: a systematic review and meta-analysis. World J Surg 2010; 34: 10-19
• 20 Ho KM, Tan JA. Stratified meta-analysis of intermittent pneumatic compression of the lower limbs to prevent venous thromboembolism in hospitalized patients. Circulation 2013; 128: 1003-1020
• 21 Antiplatelet Trialistsʼ Collaboration. Collaborative overview of randomised trials of antiplatelet therapy–III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. BMJ 1994; 308: 235-246
• 22 Kahn SR, Lim W, Dunn AS. et al. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (9th Edition). Chest 2012; 141 (Suppl. 02) S195e-S226e
• 23 Douketis JD, Eikelboom JW, Quinlan DJ. et al. Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes. Arch Intern Med 2002; 162: 1465-1471
• 24 White RH, Romano PS, Zhou H. et al. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med 1998; 158: 1525-1531
• 25 Moen V, Dahlgren N, Irestedt L. et al. Severe neurological complications after central neuroaxial blockades in Sweden 1990–1999. Anesthesiology 2004; 101: 950-959
• 26 Waurick K, Riess H, Van Aken H. et al. Rückenmarksnahe Regionalanästhesien und Thromboembolie-Prophylaxe/antithrombotische Medikation. 3. überarbeitete Empfehlung der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin. Anaesth Intensivmed 2014; 55: 464-492
• 27 Connolly G, Spyropoulos AC. Practical issues, limitations and periprocedural management of the NOACʼS. J Thromb Thrombolysis 2013; 36: 212-222
• 28 Heidbuchel H, Verhamme P, Alings M. et al. EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary. Eur Heart J 2013; 34: 2094-2106
• 29 Ulsenheimer K. Rechtliche Aspekte bei der Prophylaxe und Therapie der venösen Thrombose. Chirurg BDC 2001; 40: 104-110
• 30 Lubenow N, Hinz P, Ekkernkamp A. et al. Should patients be informed about the risk of heparin-induced thrombocytopenia before prolonged low-molecular-weight heparin thromboprophylaxis post trauma/orthopedic surgery?. Eur J Haematol 2007; 79: 187-190
• 31 Andreas M, Debong B. Thromboseprophylaxe bei Gehgips: Aufklärung über Risiken und Behandlungsalternativen. Urteil des Bundesgerichtshofs vom 21.11.1995 – VI ZR 329/94. Chirurg BDC 1997; 36: 53-54