Alopecia Areata Treated with Homoeopathic Preparation of Phosphorus: Two Evidence-Based Case Reports

Abstract

Alopecia areata (AA) is a type of non-scarring, autoimmune hair loss on the scalp or body characterised by solitary or multiple bald patches. In modern medicine, treatment is mainly in the form of corticosteroids. Homoeopathy provides a better response by framing the totality and choosing the medicine based on symptom similarity. The presented case reports evaluated the utility of individualised homoeopathic treatment on AA with evidence-based assessment. The two cases were prescribed individualised homoeopathic medicine and followed for more than 1 year. The cases were assessed by Severity Alopecia Tool (SALT) score, Measure Yourself Medical Outcome Profile 2 (MYMOP2) and periodic photographic evidence. Modified Naranjo Criteria for Homoeopathy (MONARCH) was used to assess the clinical outcome's causal attribution to the prescribed homoeopathic medicine. Both patients were given Phosphorus in centesimal potency resulting in a complete cure with a full growth of hair and without further relapse of symptoms. SALT score reduced from 24.04 to 0% in case 1 and 8.4 to 0% in case 2 after 18 months of treatment. MYMOP2 profile score declined from 3.5 to 0 in case 1 and 5.5 to 0 in case 2. The physician assessed the MONARCH score as +09 and +10 for cases 1 and 2, signifying strong causal attribution to Phosphorus prescribed in both cases. Individualised homoeopathic treatment caused improvement in AA along with general well-being. Systematic research with a larger sample size would be required to confirm observations of these two cases.

Keywords

alopecia areata - homoeopathy - individualised medicine - MYMOP2 - Modified Naranjo criteria - SALT score - Phosphorus

Patients' Consent

The patient's consent was obtained to present the cases in a peer-reviewed journal. They were assured that their identity would not be revealed in any manner.

Publication History

Article published online:
21 March 2024

• References

• 1 Amin SS, Sachdeva S. Alopecia areata: a review. J Saudi Soc Dermatol Dermatol Surg 2013; 17 (02) 37-45
• 2 Seetharam KA. Alopecia areata: an update. Indian J Dermatol Venereol Leprol 2013; 79 (05) 563-575
• 3 Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol 2015; 8: 397-403
• 4 Lee HH, Gwillim E, Patel KR. et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: a systematic review and meta-analysis. J Am Acad Dermatol 2020; 82 (03) 675-682
• 5 Brzezińska-Wcisło L, Bergler-Czop B, Wcisło-Dziadecka D, Lis-Święty A. New aspects of the treatment of alopecia areata. Postepy Dermatol Alergol 2014; 31 (04) 262-265
• 6 Bolognia J, Braverman I. Skin manifestations of internal disease. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL. et al. eds. Harrison's Principles of Internal Medicine. New York: The McGraw Hill Companies; 2008: 322-323
• 7 Strazzulla LC, Wang EHC, Avila L. et al. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol 2018; 78 (01) 1-12
• 8 Mushtaq S, Raihan M, Lone A, Mushtaq M. Alopecia areata - a literature review. Int Arch Biomed Clin Res 2017; 3 (01) 7-10
• 9 Messenger AG, McKillop J, Farrant P, McDonagh AJ, Sladden M. British Association of Dermatologists' guidelines for the management of alopecia areata 2012. Br J Dermatol 2012; 166 (05) 916-926
• 10 Ramos PM, Anzai A, Duque-Estrada B. et al. Consensus on the treatment of alopecia areata - Brazilian Society of Dermatology. An Bras Dermatol 2020; 95 (Suppl. 01) 39-52
• 11 Meah N, Wall D, York K. et al. The Alopecia Areata Consensus of Experts (ACE) study: results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol 2020; 83 (01) 123-130
• 12 Spano F, Donovan JC. Alopecia areata: Part 1: pathogenesis, diagnosis, and prognosis. Can Fam Physician 2015; 61 (09) 751-755
• 13 Ruiz-Doblado S, Carrizosa A, García-Hernández MJ. Alopecia areata: psychiatric comorbidity and adjustment to illness. Int J Dermatol 2003; 42 (06) 434-437
• 14 Fabbrocini G, Panariello L, De Vita V. et al. Quality of life in alopecia areata: a disease-specific questionnaire. J Eur Acad Dermatol Venereol 2013; 27 (03) e276-e281
• 15 Bala R, Srivastava A. Case report on hyperuricemia presenting as one-sided disease. Homœopathic Links 2019; 32 (02) 105-111
• 16 Bhasme A, Lamba P, Sajjan U. A case report of alopecia areata treated with individualized homoeopathy. Altern Ther Health Med 2023; 29 (03) 92-96
• 17 Itamura R. Effect of homeopathic treatment of 60 Japanese patients with chronic skin disease. Complement Ther Med 2007; 15 (02) 115-120
• 18 Nirwal A. Alopecia areata treated with homoeopathy. Homœopathic Links 2021; 34 (03) 249-249
• 19 Sahoo AR, Khanra J, Choubey G, Banerjee A. Curative evidence of individualised homoeopathic treatment in a case of alopecia areata. Homoep Links 2020; (e-pub ahead of print).
• 20 Shivadikar A. Evidence- based homoeopathy: case report of alopecia areata in an 11 year old boy. Indian J Res Homoeopathy 2019; 13 (04) 251-255
• 21 Tkachenko E, Okhovat JP, Manjaly P, Huang KP, Senna MM, Mostaghimi A. Complementary & alternative medicine for alopecia areata: a systematic review. J Am Acad Dermatol 2023; 88 (01) 131-143
• 22 Olsen EA, Hordinsky MK, Price VH. et al; National Alopecia Areata Foundation. Alopecia areata investigational assessment guidelines–Part II. J Am Acad Dermatol 2004; 51 (03) 440-447
• 23 Thompson E, Viksveen P, Barron S. A patient reported outcome measure in homeopathic clinical practice for long-term conditions. Homeopathy 2016; 105 (04) 309-317
• 24 Lamba CD, Gupta VK, van Haselen R. et al. Evaluation of the modified Naranjo criteria for assessing causal attribution of clinical outcome to homeopathic intervention as presented in case reports. Homeopathy 2020; 109 (04) 191-197
• 25 Schroyens F. Synthesis Repertory in RadarOpus Homeopathic Software. Belgium, Namur: Zeus Soft; 2009. . Ver. 2.2.16
• 26 Kent JT. Lectures on Homoeopathic Materia Medica. Reprint ed. New Delhi: B Jain Publishers Pvt Ltd; 1993: 824-836
• 27 Boericke W. New Manual of Homeopathic Materia Medica with Repertory. Third revised and augmented ed. New Delhi: B Jain Publishers Pvt Ltd; 2007: 450-454
• 28 van Haselen RA. Homeopathic clinical case reports: development of a supplement (HOM-CASE) to the CARE clinical case reporting guideline. Complement Ther Med 2016; 25: 78-85
• 29 Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D. CARE Group. The CARE guidelines: consensus-based clinical case reporting guideline development. BMJ Case Rep 2013; 2013: bcr2013201554
• 30 Patel RP. Chronic Miasms in Homoeopathy and Their Cure with Classification of Their Rubrics/Symptoms in Dr. Kent's Repertory. Indian Ed. New Delhi: Indian Books and Periodicals; 1996: 76
• 31 Hahnemann S. Organon of Medicine Translated by Dudgeon RE, Boericke W. 5th & 6th Ed. New Delhi: B Jain Publishers Pvt Ltd; 2010: 104
• 32 Allen JH. The Chronic Miasms with Repertory. Rearranged and Augmented Ed. New Delhi: B Jain Publishers Pvt Ltd; 2007: 566
• 33 Speight P. A Comparison of the Chronic Miasms (Psora, Pseudopsora, Syphilis, Sycosis). Reprint Ed. New Delhi: B Jain Publishers Pvt Ltd; 1998: 1-55
• 34 Banerjea S. Miasmatic Prescribing: Its Philosophy, Diagnostic Classifications, Clinical Tips, Miasmatic Repertory, Miasmatic Weightage of Medicines & Case Illustrations. Second Extended Ed. New Delhi: B Jain Publishers Pvt Ltd; 2010: 312
• 35 Bala R, Srivastava A. A review on homoeopathic remedies and their relationship. Homœopathic Links 2019; 32 (04) 209-215
• 36 Polus BI, Kimpton AJ, Walsh MJ. Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study. Chiropr Man Therap 2011; 19 (01) 7
• 37 Vernooij M, Marcelissen F. Measuring patient reported outcomes of acupuncture treatment on pain patients' health status. Complement Ther Clin Pract 2017; 28: 192-199
• 38 Kent JT. Lectures on Homeopathic Philosophy. Indian Ed. New Delhi: Pratap Medical Publishers Pvt Ltd; 1990: 224-234