Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

Martin Jozef Péč; Jakub Jurica; Monika Péčová; Jakub Benko; Juraj Sokol; Tomáš Bolek; Marek Samec; Tatiana Hurtová; Peter Galajda; Matej Samoš; Marián Mokáň

doi:10.1055/s-0043-1777071

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2024; 50(04): 609-619
DOI: 10.1055/s-0043-1777071

Review Article

Role of Platelets in Rheumatic Chronic Autoimmune Inflammatory Diseases

Martin Jozef Péč

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Jakub Jurica

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Monika Péčová

²Oncology Centre, Teaching Hospital Martin, Martin, Slovak Republic

³Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Jakub Benko

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

⁴Department of Cardiology, Teaching Hospital Nitra, Nitra, Slovak Republic

,

Juraj Sokol

³Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Tomáš Bolek

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Marek Samec

⁵Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Tatiana Hurtová

⁶Department of Dermatovenerology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

⁷Department of Infectology and Travel Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Peter Galajda

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

,

Matej Samoš

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

⁸Division of Acute and Interventional Cardiology, Department of Cardiology and Angiology II, Mid-Slovakian Institute of Heart and Vessel Diseases (SÚSCCH, a.s.), Banská Bystrica, Slovak Republic

,

Marián Mokáň

¹Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

› Author Affiliations

Abstract

Platelets are essential in maintaining blood homeostasis and regulating several inflammatory processes. They constantly interact with immune cells, have immunoregulatory functions, and can affect, through immunologically active substances, endothelium, leukocytes, and other immune response components. In reverse, inflammatory and immune processes can activate platelets, which might be significant in autoimmune disease progression and arising complications. Thus, considering this interplay, targeting platelet activity may represent a new approach to treatment of autoimmune diseases. This review aims to highlight the role of platelets in the pathogenic mechanisms of the most frequent chronic autoimmune inflammatory diseases to identify gaps in current knowledge and to provide potential new targets for medical interventions.

Keywords

psoriasis - systemic sclerosis - systemic lupus erythematosus - chronic inflammatory arthritis

Full Text

References

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