Declines in hepatic lipid metabolism are linked to the development of steatotic liver
disease and sarcopenia during aging, though the origins and directionality of these
associations remain unexplained. Impairments in Vitamin A (VitA) metabolism are evident
in steatotic liver disease, yet their functional roles have not been investigated.
This study elucidates that a Vitamin A-free diet (VAFD) influences lipid metabolism
in the aging liver. We will present specific mechanisms that contribute to this rescue
during specific time-windows of organism aging. In addition, we present data indicating
that aging-associated impairments in liver fat metabolism influences sarcopenia development
in geriatric mice by induction of specific catabolic pathways. The results support
the model that aging does not progress uniformly across all organs, highlighting hepatic
lipid metabolism as a critical vulnerability causing comorbidities , which can be
mitigated by liver-specific reactivation of lipid metabolism.
